19 items (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	CD5	T-cell surface glycoprotein CD5 isoform 1. (497 aa)
	CD80	CD80 molecule. (297 aa)
	TNFSF13B	Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (233 aa)
	CD274	CD274 molecule. (311 aa)
	CCL19	C-C motif chemokine. (100 aa)
	PDCD1LG2	IG domain-containing protein. (290 aa)
	DPP4	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa)
	EFNB1	Ephrin-B1; Belongs to the ephrin family. (346 aa)
	TMIGD2	Uncharacterized protein. (179 aa)
	TNFRSF13C	Tumor necrosis factor receptor superfamily member 13C. (186 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
	CD86	T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
	ICOS	IGv domain-containing protein. (209 aa)
	EFNB3	Ephrin-B3; Belongs to the ephrin family. (340 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
	HHLA2	HERV-H LTR-associating 2. (408 aa)
	CD28	IGv domain-containing protein. (222 aa)
	CD81	Tetraspanin. (258 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CD81	ENSSSCP00000031700	ENSSSCP00000073970	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tetraspanin.	0.467
CAV1	DPP4	ENSSSCP00000031700	ENSSSCP00000059750	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]	0.719
CCL19	CD80	ENSSSCP00000011695	ENSSSCP00000012679	C-C motif chemokine.	CD80 molecule.	0.702
CCL19	CD86	ENSSSCP00000011695	ENSSSCP00000028828	C-C motif chemokine.	T-lymphocyte activation antigen CD86 isoform 1.	0.698
CCL19	ICOS	ENSSSCP00000011695	ENSSSCP00000028023	C-C motif chemokine.	IGv domain-containing protein.	0.509
CCL19	TNFSF13B	ENSSSCP00000011695	ENSSSCP00000010188	C-C motif chemokine.	Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family.	0.429
CD274	CD28	ENSSSCP00000005602	ENSSSCP00000071532	CD274 molecule.	IGv domain-containing protein.	0.514
CD274	CD80	ENSSSCP00000005602	ENSSSCP00000012679	CD274 molecule.	CD80 molecule.	0.993
CD274	CD86	ENSSSCP00000005602	ENSSSCP00000028828	CD274 molecule.	T-lymphocyte activation antigen CD86 isoform 1.	0.590
CD274	ICOS	ENSSSCP00000005602	ENSSSCP00000028023	CD274 molecule.	IGv domain-containing protein.	0.584
CD274	PDCD1LG2	ENSSSCP00000005602	ENSSSCP00000064059	CD274 molecule.	IG domain-containing protein.	0.541
CD28	CD274	ENSSSCP00000071532	ENSSSCP00000005602	IGv domain-containing protein.	CD274 molecule.	0.514
CD28	CD5	ENSSSCP00000071532	ENSSSCP00000013949	IGv domain-containing protein.	T-cell surface glycoprotein CD5 isoform 1.	0.437
CD28	CD80	ENSSSCP00000071532	ENSSSCP00000012679	IGv domain-containing protein.	CD80 molecule.	0.996
CD28	CD86	ENSSSCP00000071532	ENSSSCP00000028828	IGv domain-containing protein.	T-lymphocyte activation antigen CD86 isoform 1.	0.997
CD28	ICOS	ENSSSCP00000071532	ENSSSCP00000028023	IGv domain-containing protein.	IGv domain-containing protein.	0.801
CD5	CD28	ENSSSCP00000013949	ENSSSCP00000071532	T-cell surface glycoprotein CD5 isoform 1.	IGv domain-containing protein.	0.437
CD5	CD80	ENSSSCP00000013949	ENSSSCP00000012679	T-cell surface glycoprotein CD5 isoform 1.	CD80 molecule.	0.703
CD5	CD86	ENSSSCP00000013949	ENSSSCP00000028828	T-cell surface glycoprotein CD5 isoform 1.	T-lymphocyte activation antigen CD86 isoform 1.	0.761
CD5	DPP4	ENSSSCP00000013949	ENSSSCP00000059750	T-cell surface glycoprotein CD5 isoform 1.	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]	0.489