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| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | FBXO7 | F-box protein 7. (606 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (534 aa) |
| | GABARAPL1 | Uncharacterized protein. (148 aa) |
| | TPI1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (285 aa) |
| | POU5F1 | POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | DAXX | Death domain associated protein. (751 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (163 aa) |
| | CUL7 | Cullin-7 isoform X6; Belongs to the cullin family. (1691 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa) |
| | MAP1LC3B | Microtubule-associated protein 1 light chain 3 beta. (125 aa) |
| | GPI | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (558 aa) |
| | GGN | Gametogenetin. (671 aa) |
| | PINK1 | PTEN induced kinase 1. (588 aa) |
| | TCP1 | Uncharacterized protein. (559 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (496 aa) |
| | TRAF1 | TNF receptor-associated factor. (415 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa) |
| | NDUFS2 | NADH dehydrogenase ubiquinone iron-sulfur protein 2, mitochondrial isoform 1; Belongs to the complex I 49 kDa subunit family. (473 aa) |
| | SCAMP3 | Secretory carrier-associated membrane protein. (347 aa) |
| | BCL10 | B-cell lymphoma/leukemia 10 isoform 1. (233 aa) |
| | MAP1LC3A | Microtubule-associated protein 1 light chain 3 alpha. (121 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa) |
| | FAM178B | Uncharacterized protein. (569 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (409 aa) |
| | LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial. (1394 aa) |
| | SMC6 | Structural maintenance of chromosomes protein 6 isoform X2. (1097 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | PDLIM2 | Uncharacterized protein. (353 aa) |
| | EGR2 | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa) |
| | VCL | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa) |
| | UBE2T | Ubiquitin-conjugating enzyme E2 T isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (231 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa) |
| | SH3KBP1 | SH3 domain containing kinase binding protein 1. (724 aa) |
| | DLG3 | Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (1056 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | OTUB1 | Ubiquitin thioesterase. (271 aa) |
| | RTN3 | Reticulon. (255 aa) |
| | AMBRA1 | Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa) |
| | MYOD1 | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa) |
| | TUBB4A | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (443 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa) |
| | ANKRA2 | Ankyrin repeat family A member 2. (313 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1055 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | ASB4 | Ankyrin repeat and SOCS box protein 4 isoform a. (426 aa) |
| | CACYBP | Calcyclin-binding protein isoform 1. (230 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4852 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | SUMO2 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] (95 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa) |
| | CASC3 | CASC3 exon junction complex subunit. (633 aa) |
| | NGFR | Nerve growth factor receptor. (414 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (539 aa) |
| | UBB | Ubiquitin B. (229 aa) |
| | UBASH3A | Ubiquitin associated and SH3 domain containing A. (685 aa) |
| | RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) |
| | RTN1 | Reticulon. (770 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) |
| | GABARAP | Uncharacterized protein. (98 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (641 aa) |
| | UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. (223 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (547 aa) |
| | LAPTM5 | Lysosomal protein transmembrane 5. (264 aa) |
| | SPOP | Speckle type BTB/POZ protein. (374 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (779 aa) |
| | CUL5 | Cullin-5; Belongs to the cullin family. (780 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (305 aa) |
| | BLZF1 | Basic leucine zipper nuclear factor 1. (401 aa) |
| | HLTF | Helicase like transcription factor. (1009 aa) |
| | UBE2L6 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa) |
| | I3LND9_PIG | Uncharacterized protein. (1222 aa) |
| | WBP1L | WW domain binding protein 1-like isoform 1. (364 aa) |
| | CASP8 | Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa) |
| | UBXN7 | UBX domain-containing protein. (519 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | MC1R | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a role in the regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis; Belongs to the G-protein coupled receptor 1 family. (320 aa) |
| | USP25 | Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa) |
| | DET1 | Uncharacterized protein. (550 aa) |
| | F2Z5U0_PIG | Ubiquitin-like domain-containing protein. (130 aa) |
| | KDM4A | Uncharacterized protein. (1066 aa) |
| | PER1 | Period circadian regulator 1. (1278 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | TRIM37 | Tripartite motif containing 37. (992 aa) |
| | FOXO1 | Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (802 aa) |
| | FAF2 | Fas associated factor family member 2. (445 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa) |
| | PRKAR2B | Protein kinase cAMP-dependent type II regulatory subunit beta. (468 aa) |
| | ARRB1 | Arrestin beta 1. (607 aa) |
| | PAX6 | Paired box 6. (498 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (840 aa) |
| | RNF34 | E3 ubiquitin-protein ligase RNF34 isoform 2. (383 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (385 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa) |
| | TXNIP | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] (391 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1062 aa) |
| | TRIM28 | Tripartite motif containing 28. (868 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1689 aa) |
| | NEK6 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...] (402 aa) |
| | PA2G4 | Proliferation-associated 2G4. (372 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | STX8 | Syntaxin 8. (301 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | RALB | RAS like proto-oncogene B. (206 aa) |
| | KCNH2 | Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (1163 aa) |
| | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X4. (553 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1364 aa) |
| | ACTG1 | Actin gamma 1. (381 aa) |
| | ISG15 | Ubiquitin-like modifier. (167 aa) |
| | CAMLG | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (300 aa) |
| | MAP1LC3C | Microtubule associated protein 1 light chain 3 gamma. (147 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (566 aa) |
| | A0A287ACW2_PIG | Peptidase_M24 domain-containing protein. (291 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | NEDD8 | NEDD8 ubiquitin like modifier. (71 aa) |
| | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (389 aa) |
| | SKI | SKI proto-oncogene. (728 aa) |
| | UBE2J1 | Ubiquitin-conjugating enzyme E2 J1. (318 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa) |
| | HM13 | Histocompatibility minor 13. (449 aa) |
| | LOC102159347 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (647 aa) |
| | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (433 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (288 aa) |
| | YOD1 | YOD1 deubiquitinase. (306 aa) |
| | PACRG | Parkin coregulated gene protein isoform 2. (257 aa) |
| | UBE2B | Ubiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | DDX58 | Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa) |
| | A0A287AMX4_PIG | Uncharacterized protein. (121 aa) |
| | BAG4 | BAG family molecular chaperone regulator 4 isoform 1. (457 aa) |
| | PRR5L | Proline rich 5 like. (473 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa) |
| | ARRDC5 | Arrestin domain containing 5. (427 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | DIO2 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa) |
| | FATE1 | Fetal and adult testis-expressed transcript protein homolog; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. (171 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | BAG2 | BCL2 associated athanogene 2. (210 aa) |
| | CUL9 | Cullin 9; Belongs to the cullin family. (2582 aa) |
| | BID | BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa) |
| | FHIT | Fragile histidine triad diadenosine triphosphatase. (150 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (204 aa) |
| | SYT11 | Synaptotagmin 11. (438 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | RTN4 | Reticulon. (1199 aa) |
| | FANCL | FA complementation group L. (378 aa) |
| | NPLOC4 | NPL4 homolog, ubiquitin recognition factor. (782 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (882 aa) |
| | CLU | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa) |
| | PATZ1 | POZ/BTB and AT hook containing zinc finger 1. (581 aa) |
| | TRIB2 | Tribbles pseudokinase 2. (343 aa) |
| | UBE2W | UBIQUITIN_CONJUGAT_2 domain-containing protein. (180 aa) |
| | PRDX6 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) |
| | RFFL | Uncharacterized protein. (799 aa) |
| | SNCAIP | Uncharacterized protein. (62 aa) |
| | FZD8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa) |
| | AXIN2 | Axin-2. (843 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (889 aa) |
| | JKAMP | JNK1/MAPK8 associated membrane protein. (325 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1169 aa) |
| | UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1. (534 aa) |
| | CACUL1 | CDK2 associated cullin domain 1; Belongs to the cullin family. (418 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa) |
| | HSPBP1 | HSPA (Hsp70) binding protein 1. (420 aa) |
| | UBOX5 | U-box domain containing 5. (541 aa) |
| | SQSTM1 | Sequestosome 1. (451 aa) |
| | LOC100737265 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa) |
| | MFN2 | Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | SPART | Spartin. (666 aa) |
| | ARRDC1 | Arrestin domain containing 1. (493 aa) |
| | HDAC6 | Histone deacetylase 6. (1159 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (373 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa) |
| | A0A287BQU9_PIG | Uncharacterized protein. (923 aa) |
| | PRKACB | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa) |
| | BAG5 | BAG family molecular chaperone regulator 5 isoform b. (447 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (668 aa) |
| | SLC22A18 | Solute carrier family 22 member 18. (446 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | ERLIN2 | ER lipid raft associated 2. (384 aa) |
| | LTBR | Uncharacterized protein. (432 aa) |
| | ARRB2 | Arrestin beta 2. (493 aa) |
| | PCBP2 | Poly(rC) binding protein 2. (467 aa) |
| | RALA | Ras-related protein Ral-A isoform X1. (206 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa) |
| | NKD2 | Uncharacterized protein. (611 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (1011 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | UBE2J2 | Ubiquitin-conjugating enzyme E2 J2. (259 aa) |
| | RNF40 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1003 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (729 aa) |
| | UBXN1 | UBX domain protein 1. (310 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | GLMN | Glomulin, FKBP associated protein. (613 aa) |
| | PACRGL | Parkin coregulated like. (293 aa) |
| | GABARAPL2 | Uncharacterized protein. (187 aa) |
| | TSG101 | UEV domain-containing protein. (67 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (227 aa) |
| | PSMA3 | Proteasome subunit alpha type. (275 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (712 aa) |
| | AICDA | Activation induced cytidine deaminase. (224 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (224 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (685 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (612 aa) |
| | SNX9 | Sorting nexin 9. (632 aa) |
| | MID1 | E3 ubiquitin-protein ligase Midline-1 isoform 1. (667 aa) |
| | CKB | Creatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (403 aa) |
| | GPR37 | G protein-coupled receptor 37. (614 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | SCN5A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa) |
| | HSPA6 | Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa) |
| | CUL2 | Cullin 2; Belongs to the cullin family. (746 aa) |
| | RTN2 | Reticulon. (527 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | GON7 | EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex. (206 aa) |
