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| | NENF | Neudesin neurotrophic factor; Belongs to the cytochrome b5 family. (169 aa) |
| | NPLOC4 | NPL4 homolog, ubiquitin recognition factor. (782 aa) |
| | CORO1B | Coronin; Belongs to the WD repeat coronin family. (496 aa) |
| | UBASH3B | Ubiquitin associated and SH3 domain containing B. (638 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | SEMA4G | Semaphorin 4G; Belongs to the semaphorin family. (838 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | GPR17 | G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (755 aa) |
| | SMPDL3B | Sphingomyelin phosphodiesterase acid like 3B. (406 aa) |
| | F12 | Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | AJAP1 | Adherens junctions associated protein 1. (527 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | GRIN3A | Glutamate ionotropic receptor NMDA type subunit 3A. (1114 aa) |
| | ADAMTS18 | ADAM metallopeptidase with thrombospondin type 1 motif 18. (1223 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1058 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | SEMA4F | Ssemaphorin 4F; Belongs to the semaphorin family. (771 aa) |
| | CLEC12B | C-type lectin domain-containing protein. (274 aa) |
| | TARBP2 | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa) |
| | THBD | Uncharacterized protein. (529 aa) |
| | SEMA5A | Semaphorin 5A. (1072 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (752 aa) |
| | TNR | Tenascin R. (1270 aa) |
| | ARRB2 | Arrestin beta 2. (493 aa) |
| | RTN4R | Reticulon 4 receptor. (548 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | PCBP2 | Poly(rC) binding protein 2. (467 aa) |
| | A0A5G2QG99_PIG | Uncharacterized protein. (2082 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1169 aa) |
| | SPINK5 | Serine peptidase inhibitor, Kazal type 5. (1023 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (509 aa) |
| | LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa) |
| | PPARA | Uncharacterized protein. (469 aa) |
| | KRT1 | Keratin 1; Belongs to the intermediate filament family. (624 aa) |
| | USP15 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (924 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (230 aa) |
| | NFKBIL1 | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). (380 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | DEFB114 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa) |
| | ARG2 | Arginase. (354 aa) |
| | RIN3 | Ras and Rab interactor 3. (918 aa) |
| | LOC110260995 | Uncharacterized protein. (123 aa) |
| | C5orf30 | UNC119-binding protein C5orf30 homolog. (207 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | RNF125 | Ring finger protein 125. (364 aa) |
| | SEMA3D | Semaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (891 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (482 aa) |
| | DCST1 | DC-STAMP domain containing 1. (707 aa) |
| | TNFAIP8L2 | Tumor necrosis factor alpha-induced protein 8-like 2. (184 aa) |
| | A0A5G2R3N8_PIG | Uncharacterized protein. (135 aa) |
| | KIAA0319 | KIAA0319. (1074 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa) |
| | LRIG2 | Leucine rich repeats and immunoglobulin like domains 2. (1065 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (925 aa) |
| | GRN | Uncharacterized protein. (656 aa) |
| | MEFV | Pyrin domain-containing protein. (102 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | PLG | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | KNG1 | Kininogen 1. (630 aa) |
| | STAT2 | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa) |
| | TTLL12 | Tubulin tyrosine ligase like 12. (604 aa) |
| | TAFA3 | Uncharacterized protein. (133 aa) |
| | TRAF3IP1 | TRAF3 interacting protein 1. (666 aa) |
| | ANGPT2 | Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa) |
| | ROBO1 | Roundabout guidance receptor 1. (1687 aa) |
| | LOC100739719 | Tetraspanin. (245 aa) |
| | BBS4 | Uncharacterized protein. (826 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | YTHDF2 | YTH N6-methyladenosine RNA binding protein 2. (600 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (770 aa) |
| | C1QBP | Mitochondrial complement component 1 Q subcomponent-binding protein. (281 aa) |
| | RTN4RL1 | Reticulon 4 receptor like 1. (518 aa) |
| | RABGEF1 | Uncharacterized protein. (503 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | C5AR2 | Complement component 5a receptor 2. (434 aa) |
| | C1QTNF12 | C1q and TNF related 12. (308 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | GPATCH3 | G-patch domain containing 3. (535 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | RORA | RAR related orphan receptor A. (530 aa) |
| | SEMA6D | Semaphorin 6D; Belongs to the semaphorin family. (1086 aa) |
| | MAPKBP1 | Mitogen-activated protein kinase binding protein 1. (1502 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (913 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | SELENOS | Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa) |
| | LRFN5 | Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (723 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (400 aa) |
| | CCN3 | Cellular communication network factor 3. (398 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | CST7 | Cystatin domain-containing protein. (146 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | PPM1B | PPM-type phosphatase domain-containing protein. (473 aa) |
| | LYAR | Ly1 antibody reactive. (386 aa) |
| | OTOP1 | Otopetrin 1. (612 aa) |
| | SLIT2 | Slit guidance ligand 2. (1542 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (295 aa) |
| | FGB | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa) |
| | GRID2 | Glutamate ionotropic receptor delta type subunit 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (616 aa) |
| | MMRN1 | Multimerin 1. (1220 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | CPB2 | Carboxypeptidase B2 isoform 1 preproprotein. (423 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | SH2B3 | SH2B adaptor protein 3. (600 aa) |
| | TRAFD1 | TRAF-type zinc finger domain containing 1. (581 aa) |
| | MVK | Mevalonate kinase. (454 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | MIF | Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa) |
| | MYOZ1 | Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). (297 aa) |
| | PLAU | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa) |
| | FFAR4 | Free fatty acid receptor 4 isoform GPR120-S. (361 aa) |
| | INPP5F | Phosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | SUSD4 | Sushi domain containing 4. (460 aa) |
| | SEMA3F | Semaphorin 3F; Belongs to the semaphorin family. (777 aa) |
| | SEMA3G | Semaphorin-3G; Belongs to the semaphorin family. (771 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) |
| | RYK | Receptor like tyrosine kinase. (566 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | HRG | Uncharacterized protein. (561 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa) |
| | TSPAN6 | Tetraspanin. (245 aa) |
| | VSIG1 | Uncharacterized protein. (1377 aa) |
| | TKFC | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (By similarity). Belongs to the dihydroxyacetone kinase (DAK) family. (508 aa) |
| | SERPING1 | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | F2 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa) |
| | NUCB2 | Uncharacterized protein. (472 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | TRIM21 | Tripartite motif containing 21. (474 aa) |
| | NLRX1 | NLR family member X1 isoform X1. (975 aa) |
| | RNF26 | E3 ubiquitin-protein ligase RNF26. (433 aa) |
| | SEMA3E | Semaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | FGL2 | Fibroleukin. (495 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | KLKB1 | Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | C1QTNF3 | Complement C1q tumor necrosis factor-related protein 3 isoform b. (319 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | CARTPT | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Belongs to the CART family. (116 aa) |
| | SLC6A3 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa) |
| | SEC14L1 | SEC14 like lipid binding 1. (707 aa) |
| | DHX58 | DExH-box helicase 58. (681 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa) |
| | GIT1 | GIT ArfGAP 1. (761 aa) |
| | GP1BA | Platelet glycoprotein Ib alpha polypeptide. (627 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2963 aa) |
| | TNFAIP6 | Uncharacterized protein. (277 aa) |
| | SEMA3C | Semaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | SEMA7A | Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa) |
| | ZFP36 | Uncharacterized protein. (372 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa) |
| | PTPRS | Protein tyrosine phosphatase receptor type S. (1946 aa) |
| | METTL3 | N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (305 aa) |
| | FGG | Fibrinogen gamma chain. (454 aa) |
| | NMI | N-myc and STAT interactor. (307 aa) |
| | NR1D2 | Uncharacterized protein. (609 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa) |
| | PADI2 | Peptidyl arginine deiminase 2. (689 aa) |
| | SEMA3A | Semaphorin 3A; Belongs to the semaphorin family. (800 aa) |
| | CD9 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (226 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (283 aa) |
| | WFDC1 | WAP four-disulfide core domain 1. (221 aa) |
| | PHLDB2 | Pleckstrin homology like domain family B member 2. (1253 aa) |
| | SERPINE1 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa) |
| | PROC | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa) |
| | LTF | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (727 aa) |
| | C1QTNF6 | C1q domain-containing protein. (285 aa) |
| | LOC100513863 | Uncharacterized protein. (709 aa) |
| | PLXNA3 | Plexin A3. (1871 aa) |
| | CD109 | CD109 antigen isoform 1 preproprotein. (1449 aa) |
| | APOH | Beta-2-glycoprotein 1. (345 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa) |
| | AOAH | Acyloxyacyl hydrolase. (575 aa) |
| | SEMA4D | Semaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | IL13 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (638 aa) |
| | K7GSB8_PIG | Ig-like domain-containing protein. (331 aa) |
| | LOC100737180 | C-X-C motif chemokine 17. (119 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (353 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | CD96 | CD96 molecule. (571 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | KLK8 | Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa) |
| | SPX | Spexin hormone. (118 aa) |
| | MKRN2 | Putative E3 ubiquitin-protein ligase makorin-2 isoform 1. (488 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1846 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (221 aa) |
| | SEMA6C | Semaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (385 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1062 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa) |
| | F11 | Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | GPR18 | N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa) |
| | AIF1 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations. (147 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | FEM1A | Protein fem-1 homolog A. (664 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (338 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | A0A287A514_PIG | NR LBD domain-containing protein. (88 aa) |
| | PROS1 | Protein S. (702 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa) |
| | CXCL13 | C-X-C motif chemokine. (111 aa) |
| | SEMA3B | Semaphorin 3B; Belongs to the semaphorin family. (747 aa) |
| | CD200 | OX-2 membrane glycoprotein isoform X2. (301 aa) |
| | ISG15 | Ubiquitin-like modifier. (167 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | CLDN19 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (458 aa) |
| | ILRUN | N_BRCA1_IG domain-containing protein. (217 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | PRKG1 | cGMP-dependent protein kinase. (686 aa) |
| | HAMP | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa) |
| | FOXF1 | Forkhead box protein F1. (423 aa) |
| | VSIG4 | V-set and immunoglobulin domain containing 4. (399 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (873 aa) |
| | CD46 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (381 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1274 aa) |
| | C5 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. (1677 aa) |
| | A0A287AK40_PIG | Uncharacterized protein. (341 aa) |
| | FNDC4 | Fibronectin type III domain containing 4. (233 aa) |
| | SEMA6B | Semaphorin-6B; Belongs to the semaphorin family. (901 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | SEMA4B | Semaphorin 4B; Belongs to the semaphorin family. (835 aa) |
| | SEMA4A | Semaphorin-4A isoform X2; Belongs to the semaphorin family. (791 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | C1QTNF1 | C1q and TNF related 1. (273 aa) |
| | LOC100517427 | Uncharacterized protein. (299 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | MMP28 | Matrix metallopeptidase 28. (521 aa) |
| | NFKB1 | Uncharacterized protein. (898 aa) |
| | PLA2G10 | Phospholipase A(2). (188 aa) |
| | NLRC3 | NLR family CARD domain-containing protein 3. (1066 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (356 aa) |
| | TFPI | Tissue factor pathway inhibitor. (303 aa) |
| | YTHDF3 | YTH domain-containing family protein 3 isoform b. (588 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (378 aa) |
| | PSMB4 | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (264 aa) |
| | SEMA4C | Semaphorin 4C; Belongs to the semaphorin family. (896 aa) |
| | NDFIP1 | Uncharacterized protein. (254 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | A0A287B199_PIG | Ig-like domain-containing protein. (313 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | SYT11 | Synaptotagmin 11. (438 aa) |
| | RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa) |
| | SEMA5B | Semaphorin 5B. (1126 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (229 aa) |
| | SEMA6A | Semaphorin-6A isoform 1; Belongs to the semaphorin family. (1047 aa) |
