STRINGSTRING
ADRA2B ADRA2B ADRA2A ADRA2A INSR INSR PPIA PPIA ADRA2C ADRA2C OSBPL8 OSBPL8 MT3 MT3 ITGB1BP1 ITGB1BP1 PDPK1 PDPK1 FGF1 FGF1 WNT5A WNT5A PDGFB PDGFB LOC102160380 LOC102160380 INS INS LOC106508962 LOC106508962 GAS6 GAS6 A0A5G2R326_PIG A0A5G2R326_PIG ANG ANG NTRK3 NTRK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRA2BAlpha-2B adrenergic receptor. (446 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
ADRA2CAdrenoceptor alpha 2C. (460 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (270 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
LOC102160380Uncharacterized protein. (472 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
LOC106508962Dynactin-associated protein. (160 aa)
GAS6Uncharacterized protein. (682 aa)
A0A5G2R326_PIGCLLAC domain-containing protein. (492 aa)
ANGRibonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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