| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADRA2A | ADRA2B | ENSSSCP00000011323 | ENSSSCP00000008672 | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Alpha-2B adrenergic receptor. | 0.501 |
| ADRA2A | ADRA2C | ENSSSCP00000011323 | ENSSSCP00000022833 | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Adrenoceptor alpha 2C. | 0.437 |
| ADRA2B | ADRA2A | ENSSSCP00000008672 | ENSSSCP00000011323 | Alpha-2B adrenergic receptor. | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | 0.501 |
| ADRA2B | ADRA2C | ENSSSCP00000008672 | ENSSSCP00000022833 | Alpha-2B adrenergic receptor. | Adrenoceptor alpha 2C. | 0.503 |
| ADRA2C | ADRA2A | ENSSSCP00000022833 | ENSSSCP00000011323 | Adrenoceptor alpha 2C. | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | 0.437 |
| ADRA2C | ADRA2B | ENSSSCP00000022833 | ENSSSCP00000008672 | Adrenoceptor alpha 2C. | Alpha-2B adrenergic receptor. | 0.503 |
| FGF1 | INS | ENSSSCP00000037435 | ENSSSCP00000044635 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.694 |
| FGF1 | INSR | ENSSSCP00000037435 | ENSSSCP00000014414 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Tyrosine-protein kinase receptor. | 0.670 |
| FGF1 | PDGFB | ENSSSCP00000037435 | ENSSSCP00000041857 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.416 |
| INS | FGF1 | ENSSSCP00000044635 | ENSSSCP00000037435 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.694 |
| INS | INSR | ENSSSCP00000044635 | ENSSSCP00000014414 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.998 |
| INSR | FGF1 | ENSSSCP00000014414 | ENSSSCP00000037435 | Tyrosine-protein kinase receptor. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.670 |
| INSR | INS | ENSSSCP00000014414 | ENSSSCP00000044635 | Tyrosine-protein kinase receptor. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.998 |
| INSR | PDPK1 | ENSSSCP00000014414 | ENSSSCP00000035547 | Tyrosine-protein kinase receptor. | 3-phosphoinositide dependent protein kinase 1. | 0.417 |
| PDGFB | FGF1 | ENSSSCP00000041857 | ENSSSCP00000037435 | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.416 |
| PDPK1 | INSR | ENSSSCP00000035547 | ENSSSCP00000014414 | 3-phosphoinositide dependent protein kinase 1. | Tyrosine-protein kinase receptor. | 0.417 |