STRINGSTRING
SOX5 SOX5 ADAMTS7 ADAMTS7 SMAD7 SMAD7 BMP4 BMP4 SIX2 SIX2 PKDCC PKDCC IHH IHH HOXA11 HOXA11 GLI3 GLI3 SOX9 SOX9 SHOX2 SHOX2 GDF5 GDF5 GLG1 GLG1 ADAMTS12 ADAMTS12 FGF18 FGF18 TGFBR1 TGFBR1 MAF MAF CTNNB1 CTNNB1 RARG RARG ZBTB16 ZBTB16 ZNF219 ZNF219 NKX3-2 NKX3-2 CCN2 CCN2 SNAI2 SNAI2 GREM1 GREM1 RFLNA RFLNA SCIN SCIN SOX6 SOX6 LOXL2 LOXL2 PTHLH PTHLH RFLNB RFLNB EFEMP1 EFEMP1 CCN4 CCN4 CHADL CHADL AXIN2 AXIN2 GDF6 GDF6 LTBP3 LTBP3 LNPK LNPK PTPN11 PTPN11 RUNX2 RUNX2 SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX5SRY-box transcription factor 5. (763 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1660 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX2SIX homeobox 2. (296 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
SHOX2Short stature homeobox 2. (321 aa)
GDF5Growth differentiation factor 5. (499 aa)
GLG1Golgi glycoprotein 1. (1210 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (408 aa)
CTNNB1Catenin beta 1. (808 aa)
RARGRetinoic acid receptor gamma. (554 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ZNF219Zinc finger protein 219. (716 aa)
NKX3-2NK3 homeobox 2. (337 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
RFLNAUncharacterized protein. (266 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
SOX6SRY-box transcription factor 6. (859 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
RFLNBRefilin-B. (219 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (512 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
CHADLChondroadherin like. (760 aa)
AXIN2Axin-2. (843 aa)
GDF6Growth/differentiation factor 6 preproprotein. (459 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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