STRINGSTRING
ADAMTS7 ADAMTS7 NKX3-2 NKX3-2 SNAI2 SNAI2 GREM1 GREM1 RFLNA RFLNA PTHLH PTHLH RFLNB RFLNB EFEMP1 EFEMP1 CCN4 CCN4 CHADL CHADL LTBP3 LTBP3 PTPN11 PTPN11 BMP4 BMP4 IHH IHH GLI3 GLI3 SOX9 SOX9 GDF5 GDF5 ADAMTS12 ADAMTS12 TGFBR1 TGFBR1 CTNNB1 CTNNB1 RARG RARG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1660 aa)
NKX3-2NK3 homeobox 2. (337 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
RFLNAUncharacterized protein. (266 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
RFLNBRefilin-B. (219 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (512 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
CHADLChondroadherin like. (760 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
GDF5Growth differentiation factor 5. (499 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
CTNNB1Catenin beta 1. (808 aa)
RARGRetinoic acid receptor gamma. (554 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.