47 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (539 aa)
	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa)
	PEPD	Peptidase D. (526 aa)
	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif 3. (1220 aa)
	TNS2	Tensin 2. (1350 aa)
	COL1A1	Collagen type I alpha 1 chain. (1477 aa)
	MMP19	Matrix metallopeptidase 19. (506 aa)
	P3H3	Prolyl 3-hydroxylase 3. (727 aa)
	MMP23B	Matrix metallopeptidase 23B. (391 aa)
	COL5A1	Fibrillar collagen NC1 domain-containing protein. (1918 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (341 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	MMP11	Stromelysin-3 preproprotein. (463 aa)
	CTSL	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
	CTSV	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
	P3H2	Prolyl 3-hydroxylase 2 isoform a. (706 aa)
	MMP7	ZnMc domain-containing protein. (267 aa)
	MMP20	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity). (483 aa)
	MMP27	Matrix metallopeptidase 27. (511 aa)
	MMP8	Matrix metallopeptidase 8. (468 aa)
	MMP1	Stromelysin-1 preproprotein. (477 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (455 aa)
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (650 aa)
	MMP2	Uncharacterized protein. (610 aa)
	MMP15	Matrix metallopeptidase 15. (712 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (824 aa)
	MMP9	Matrix metalloproteinase-9. (708 aa)
	RETREG3	Reticulophagy regulator family member 3. (466 aa)
	MMP12	Macrophage metalloelastase preproprotein. (476 aa)
	MMP13	Matrix metallopeptidase 13. (470 aa)
	COL1A2	Fibrillar collagen NC1 domain-containing protein. (1135 aa)
	RETREG2	Reticulophagy regulator family member 2. (542 aa)
	MRC2	Mannose receptor C type 2. (1264 aa)
	MMP17	Matrix metalloproteinase-17 preproprotein. (595 aa)
	P3H1	Prolyl 3-hydroxylase 1 isoform 1. (698 aa)
	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif 2. (1204 aa)
	MMP14	Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
	MMP25	Matrix metallopeptidase 25. (566 aa)
	RCN3	Reticulocalbin 3. (335 aa)
	TNXB	Uncharacterized protein. (4137 aa)
	RETREG1	Reticulophagy regulator 1. (565 aa)
	SERPINH1	SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
	TRAM2	Translocation associated membrane protein 2. (392 aa)
	MMP16	Matrix metalloproteinase-16. (607 aa)
	MMP24	Matrix metallopeptidase 24. (635 aa)
	MMP28	Matrix metallopeptidase 28. (521 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS2	COL1A1	ENSSSCP00000021077	ENSSSCP00000066291	ADAM metallopeptidase with thrombospondin type 1 motif 2.	Collagen type I alpha 1 chain.	0.737
ADAMTS2	COL1A2	ENSSSCP00000021077	ENSSSCP00000016253	ADAM metallopeptidase with thrombospondin type 1 motif 2.	Fibrillar collagen NC1 domain-containing protein.	0.717
ADAMTS2	COL5A1	ENSSSCP00000021077	ENSSSCP00000006161	ADAM metallopeptidase with thrombospondin type 1 motif 2.	Fibrillar collagen NC1 domain-containing protein.	0.675
ADAMTS2	TNXB	ENSSSCP00000021077	ENSSSCP00000030534	ADAM metallopeptidase with thrombospondin type 1 motif 2.	Uncharacterized protein.	0.605
ADAMTS3	COL1A1	ENSSSCP00000065940	ENSSSCP00000066291	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Collagen type I alpha 1 chain.	0.481
ADAMTS3	COL1A2	ENSSSCP00000065940	ENSSSCP00000016253	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Fibrillar collagen NC1 domain-containing protein.	0.505
ADAMTS3	COL5A1	ENSSSCP00000065940	ENSSSCP00000006161	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Fibrillar collagen NC1 domain-containing protein.	0.451
ADAMTS3	MMP12	ENSSSCP00000065940	ENSSSCP00000015911	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Macrophage metalloelastase preproprotein.	0.417
ADAMTS3	MMP13	ENSSSCP00000065940	ENSSSCP00000015912	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Matrix metallopeptidase 13.	0.431
ADAMTS3	MMP27	ENSSSCP00000065940	ENSSSCP00000015907	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Matrix metallopeptidase 27.	0.581
COL1A1	ADAMTS2	ENSSSCP00000066291	ENSSSCP00000021077	Collagen type I alpha 1 chain.	ADAM metallopeptidase with thrombospondin type 1 motif 2.	0.737
COL1A1	ADAMTS3	ENSSSCP00000066291	ENSSSCP00000065940	Collagen type I alpha 1 chain.	ADAM metallopeptidase with thrombospondin type 1 motif 3.	0.481
COL1A1	COL1A2	ENSSSCP00000066291	ENSSSCP00000016253	Collagen type I alpha 1 chain.	Fibrillar collagen NC1 domain-containing protein.	0.999
COL1A1	COL5A1	ENSSSCP00000066291	ENSSSCP00000006161	Collagen type I alpha 1 chain.	Fibrillar collagen NC1 domain-containing protein.	0.859
COL1A1	CTSS	ENSSSCP00000066291	ENSSSCP00000007089	Collagen type I alpha 1 chain.	Cathepsin S; Belongs to the peptidase C1 family.	0.417
COL1A1	MMP1	ENSSSCP00000066291	ENSSSCP00000015910	Collagen type I alpha 1 chain.	Stromelysin-1 preproprotein.	0.648
COL1A1	MMP11	ENSSSCP00000066291	ENSSSCP00000010744	Collagen type I alpha 1 chain.	Stromelysin-3 preproprotein.	0.457
COL1A1	MMP12	ENSSSCP00000066291	ENSSSCP00000015911	Collagen type I alpha 1 chain.	Macrophage metalloelastase preproprotein.	0.478
COL1A1	MMP13	ENSSSCP00000066291	ENSSSCP00000015912	Collagen type I alpha 1 chain.	Matrix metallopeptidase 13.	0.700
COL1A1	MMP14	ENSSSCP00000066291	ENSSSCP00000022437	Collagen type I alpha 1 chain.	Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...]	0.459