node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA1 | ABCG1 | ENSSSCP00000005818 | ENSSSCP00000053363 | Uncharacterized protein. | ATP binding cassette subfamily G member 1. | 0.538 |
ABCA1 | APOA1 | ENSSSCP00000005818 | ENSSSCP00000033805 | Uncharacterized protein. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.996 |
ABCA1 | APOA2 | ENSSSCP00000005818 | ENSSSCP00000069906 | Uncharacterized protein. | Apolipoprotein A-II preproprotein. | 0.584 |
ABCA1 | APOB | ENSSSCP00000005818 | ENSSSCP00000042786 | Uncharacterized protein. | Apolipoprotein B-100. | 0.738 |
ABCA1 | APOC3 | ENSSSCP00000005818 | ENSSSCP00000063050 | Uncharacterized protein. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.646 |
ABCA1 | APOE | ENSSSCP00000005818 | ENSSSCP00000003343 | Uncharacterized protein. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.912 |
ABCA1 | NPC2 | ENSSSCP00000005818 | ENSSSCP00000073764 | Uncharacterized protein. | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmos [...] | 0.463 |
ABCA1 | SCARB1 | ENSSSCP00000005818 | ENSSSCP00000010421 | Uncharacterized protein. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. | 0.861 |
ABCA7 | APOA1 | ENSSSCP00000037695 | ENSSSCP00000033805 | ATP binding cassette subfamily A member 7. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.942 |
ABCA7 | APOE | ENSSSCP00000037695 | ENSSSCP00000003343 | ATP binding cassette subfamily A member 7. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.663 |
ABCG1 | ABCA1 | ENSSSCP00000053363 | ENSSSCP00000005818 | ATP binding cassette subfamily G member 1. | Uncharacterized protein. | 0.538 |
ABCG1 | ABCG5 | ENSSSCP00000053363 | ENSSSCP00000033051 | ATP binding cassette subfamily G member 1. | ATP binding cassette subfamily G member 5. | 0.669 |
ABCG1 | APOA1 | ENSSSCP00000053363 | ENSSSCP00000033805 | ATP binding cassette subfamily G member 1. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.821 |
ABCG1 | APOB | ENSSSCP00000053363 | ENSSSCP00000042786 | ATP binding cassette subfamily G member 1. | Apolipoprotein B-100. | 0.577 |
ABCG1 | APOE | ENSSSCP00000053363 | ENSSSCP00000003343 | ATP binding cassette subfamily G member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.793 |
ABCG1 | SCARB1 | ENSSSCP00000053363 | ENSSSCP00000010421 | ATP binding cassette subfamily G member 1. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. | 0.830 |
ABCG4 | ABCG5 | ENSSSCP00000016036 | ENSSSCP00000033051 | ATP-binding cassette sub-family G member 4 isoform a. | ATP binding cassette subfamily G member 5. | 0.603 |
ABCG4 | APOA1 | ENSSSCP00000016036 | ENSSSCP00000033805 | ATP-binding cassette sub-family G member 4 isoform a. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.518 |
ABCG4 | SCARB1 | ENSSSCP00000016036 | ENSSSCP00000010421 | ATP-binding cassette sub-family G member 4 isoform a. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. | 0.463 |
ABCG5 | ABCG1 | ENSSSCP00000033051 | ENSSSCP00000053363 | ATP binding cassette subfamily G member 5. | ATP binding cassette subfamily G member 1. | 0.669 |