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GPX1 GPX1 EDN1 EDN1 PTGS1 PTGS1 A0A287ARF8_PIG A0A287ARF8_PIG GPX4 GPX4 PLA2G10 PLA2G10 ELOVL2 ELOVL2 ELOVL1 ELOVL1 CD74 CD74 DAGLB DAGLB CYP1B1 CYP1B1 CYP2C36 CYP2C36 PLA2G4A PLA2G4A DECR2 DECR2 AKR1B1 AKR1B1 PTGDS PTGDS CYP2E1 CYP2E1 PLAA PLAA A0A5G2R3N8_PIG A0A5G2R3N8_PIG SCD SCD AKR1C1 AKR1C1 CYP2S1 CYP2S1 ZADH2 ZADH2 PTGR1 PTGR1 EDN2 EDN2 CYP2U1 CYP2U1 ELOVL6 ELOVL6 LOC110256857 LOC110256857 TNFRSF1A TNFRSF1A PTGS2 PTGS2 MGLL MGLL ACOX1 ACOX1 PLA2G2F PLA2G2F ALOX5 ALOX5 ALOX15 ALOX15 ELOVL5 ELOVL5 PRXL2B PRXL2B LOC100737508 LOC100737508 ALOXE3 ALOXE3 ALOX12B ALOX12B ALOX15B ALOX15B TBXAS1 TBXAS1 PNPLA8 PNPLA8 DAGLA DAGLA FADS1 FADS1 FADS3 FADS3 LOC100739163 LOC100739163 AKR1E2 AKR1E2 EPHX1 EPHX1 ELOVL3 ELOVL3 CYP2C33 CYP2C33 MIF MIF HPGD HPGD SCD5 SCD5 HPGDS HPGDS ATP6V1B1 ATP6V1B1 PTGIS PTGIS PTGES PTGES PTGES2 PTGES2 PLA2G4F PLA2G4F ELOVL4 ELOVL4 CYP2B22 CYP2B22 CYP2F1 CYP2F1 CYP2A19 CYP2A19 PTGES3 PTGES3 CYP2D25 CYP2D25 PTGR2 PTGR2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
PTGS1Prostaglandin G/H synthase 1 isoform 1. (600 aa)
A0A287ARF8_PIGUncharacterized protein. (161 aa)
GPX4Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of s [...] (197 aa)
PLA2G10Phospholipase A(2). (188 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (347 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
DAGLBDiacylglycerol lipase beta. (691 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
CYP2C36Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (843 aa)
PLA2G4APhospholipase A2. (758 aa)
DECR2Peroxisomal 2,4-dienoyl-CoA reductase. (320 aa)
AKR1B1Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes th [...] (317 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (297 aa)
CYP2E1Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (499 aa)
PLAAPhospholipase A2 activating protein. (1044 aa)
A0A5G2R3N8_PIGUncharacterized protein. (135 aa)
SCDAcyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (425 aa)
AKR1C1Aldo-keto reductase family 1 member C3 isoform 2. (324 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (650 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
PTGR1Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. (329 aa)
EDN2Endothelin 2. (180 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
LOC110256857Uncharacterized protein. (162 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
MGLLMonoglyceride lipase. (456 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
PLA2G2FPhospholipase A(2). (302 aa)
ALOX5Arachidonate 5-lipoxygenase. (638 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (325 aa)
PRXL2BProstamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). (202 aa)
LOC100737508Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ALOXE3Arachidonate lipoxygenase 3. (710 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (698 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (718 aa)
TBXAS1Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)
PNPLA8Calcium-independent phospholipase A2-gamma isoform 1. (783 aa)
DAGLADiacylglycerol lipase alpha. (1058 aa)
FADS1Cytochrome b5 heme-binding domain-containing protein. (481 aa)
FADS3Fatty acid desaturase 3. (443 aa)
LOC100739163Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (309 aa)
AKR1E21,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. (301 aa)
EPHX1Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. (452 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
CYP2C33Cytochrome P450 2C8 isoform a; Belongs to the cytochrome P450 family. (494 aa)
MIFMacrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
HPGD15-hydroxyprostaglandin dehydrogenase NAD(+) isoform 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
PTGESMicrosomal prostaglandin E synthase-1. (153 aa)
PTGES2Prostaglandin E synthase 2. (372 aa)
PLA2G4FPhospholipase A2. (852 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (321 aa)
CYP2B22Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (492 aa)
CYP2A19Cytochorme P450 2A19; Belongs to the cytochrome P450 family. (494 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
CYP2D25Vitamin D(3) 25-hydroxylase; Catalyzes the first step in the metabolic activation of vitamin D(3) into 1-alpha,25-dihydroxyvitamin D(3), its active, hormonal form. (500 aa)
PTGR2Prostaglandin reductase 2 isoform X1. (351 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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