STRINGSTRING
CTIF CTIF RPS6KB2 RPS6KB2 PAIP1 PAIP1 MIEF1 MIEF1 LOC100624149 LOC100624149 HABP4 HABP4 METTL14 METTL14 YTHDF3 YTHDF3 FASTKD3 FASTKD3 CASP3 CASP3 EIF5A EIF5A SNTA1 SNTA1 EIF5A2 EIF5A2 PRR16 PRR16 UPF3A UPF3A CNBP CNBP EIF4G1 EIF4G1 PYM1 PYM1 ABCG1 ABCG1 A0A287BBY0_PIG A0A287BBY0_PIG PRKCD PRKCD TRMT10C TRMT10C NCK2 NCK2 NOD2 NOD2 CSDE1 CSDE1 LRRTM3 LRRTM3 TARBP2 TARBP2 LARP4B LARP4B NFE2L2 NFE2L2 C1QBP C1QBP YTHDF2 YTHDF2 UHMK1 UHMK1 CCN1 CCN1 EIF3D EIF3D RPS6KB1 RPS6KB1 METTL5 METTL5 MRPS27 MRPS27 POLR2G POLR2G POLDIP3 POLDIP3 SAMD4A SAMD4A EIF6 EIF6 C7H6orf125 C7H6orf125 DAZL DAZL BOLL BOLL GSAP GSAP USP16 USP16 MIF4GD MIF4GD YTHDF1 YTHDF1 EIF2S3 EIF2S3 BCL3 BCL3 FMR1 FMR1 LARP4 LARP4 NIBAN1 NIBAN1 DHX9 DHX9 ABCF1 ABCF1 ZCCHC4 ZCCHC4 PABPC1 PABPC1 DHX36 DHX36 KHDRBS1 KHDRBS1 DHX29 DHX29 NCK1 NCK1 EEF2 EEF2 IL6 IL6 FXR1 FXR1 I3LH22_PIG I3LH22_PIG METTL3 METTL3 RPS9 RPS9 PIWIL2 PIWIL2 DNAJC3 DNAJC3 IGF2BP1 IGF2BP1 SPHK2 SPHK2 RBM3 RBM3 FXR2 FXR2 ERBB2 ERBB2 EIF4A3 EIF4A3 LARP1 LARP1 EPHA4 EPHA4 FASTKD2 FASTKD2 RPUSD4 RPUSD4 PICALM PICALM JMJD4 JMJD4 MPV17L2 MPV17L2 ELAVL1 ELAVL1 NAT10 NAT10 RELA RELA UPF3B UPF3B DDX3X DDX3X RPUSD3 RPUSD3 HNRNPD HNRNPD GUF1 GUF1 RCC1L RCC1L PCIF1 PCIF1 BARHL2 BARHL2 EFNA1 EFNA1 EIF3E EIF3E LARP6 LARP6 THBS1 THBS1 SYNCRIP SYNCRIP RMND1 RMND1 PINK1 PINK1 MTOR MTOR GSK3A GSK3A SLC2A13 SLC2A13 HNRNPU HNRNPU AURKA AURKA PLA2G6 PLA2G6 IFNG IFNG SP1 SP1 PLD1 PLD1 LARP1B LARP1B TENT5B TENT5B ZCCHC13 ZCCHC13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTIFCap binding complex dependent translation initiation factor. (608 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (526 aa)
PAIP1Poly(A) binding protein interacting protein 1. (480 aa)
MIEF1Mitochondrial dynamics protein MID51 isoform X1. (463 aa)
LOC100624149Tr-type G domain-containing protein. (493 aa)
HABP4Intracellular hyaluronan-binding protein 4. (418 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
YTHDF3YTH domain-containing family protein 3 isoform b. (588 aa)
FASTKD3FAST kinase domains 3. (662 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
EIF5AeIF-5a domain-containing protein. (311 aa)
SNTA1Uncharacterized protein. (1071 aa)
EIF5A2Eukaryotic translation initiation factor 5A. (153 aa)
PRR16Protein Largen isoform X1. (304 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (502 aa)
CNBPCCHC-type zinc finger nucleic acid binding protein. (167 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1613 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (266 aa)
ABCG1ATP binding cassette subfamily G member 1. (679 aa)
A0A287BBY0_PIGUncharacterized protein. (164 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit. (415 aa)
NCK2Cytoplasmic protein. (376 aa)
NOD2Uncharacterized protein. (1013 aa)
CSDE1Cold shock domain containing E1. (851 aa)
LRRTM3Leucine-rich repeat transmembrane neuronal protein 3. (581 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
LARP4BHTH La-type RNA-binding domain-containing protein. (1587 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
C1QBPMitochondrial complement component 1 Q subcomponent-binding protein. (281 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
UHMK1Serine/threonine-protein kinase Kist isoform 1. (419 aa)
CCN1Cellular communication network factor 1. (382 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (548 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
METTL5Methyltransferase like 5. (226 aa)
MRPS27Mitochondrial ribosomal protein S27. (455 aa)
POLR2GRNA polymerase II subunit G. (231 aa)
POLDIP3Polymerase delta-interacting protein 3 isoform X1. (420 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
C7H6orf125Uncharacterized protein. (173 aa)
DAZLDeleted in azoospermia-like protein. (295 aa)
BOLLBoule homolog, RNA binding protein. (430 aa)
GSAPGamma-secretase activating protein. (850 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (823 aa)
MIF4GDMIF4G domain containing. (224 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
EIF2S3Eukaryotic translation initiation factor 2 subunit 3. (472 aa)
BCL3ANK_REP_REGION domain-containing protein. (453 aa)
FMR1Fragile X mental retardation protein 1. (632 aa)
LARP4La ribonucleoprotein domain family member 4. (821 aa)
NIBAN1Protein Niban. (934 aa)
DHX9ATP-dependent RNA helicase A. (1384 aa)
ABCF1ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. (824 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4 isoform 1. (513 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (443 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1366 aa)
NCK1Cytoplasmic protein. (377 aa)
EEF2Eukaryotic translation elongation factor 2. (863 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
FXR1Fragile X mental retardation syndrome-related protein 1 isoform X1. (677 aa)
I3LH22_PIGRRM domain-containing protein. (156 aa)
METTL3N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa)
RPS940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (985 aa)
DNAJC3Uncharacterized protein. (504 aa)
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa)
SPHK2Sphingosine kinase 2. (653 aa)
RBM3Uncharacterized protein. (155 aa)
FXR2FMR1 autosomal homolog 2. (667 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
LARP1La ribonucleoprotein domain family member 1. (1101 aa)
EPHA4EPH receptor A4. (986 aa)
FASTKD2FAST kinase domain-containing protein 2, mitochondrial. (689 aa)
RPUSD4RNA pseudouridylate synthase domain-containing protein 4. (376 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (700 aa)
JMJD4JmjC domain-containing protein 4 isoform X1. (424 aa)
MPV17L2MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (235 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
RELATranscription factor p65 isoform 1. (573 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (483 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
RPUSD3Mitochondrial mRNA pseudouridine synthase RPUSD3 isoform 1. (352 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D0 isoform a. (355 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
RCC1LRCC1 like. (490 aa)
PCIF1Phosphorylated CTD-interacting factor 1 isoform X1. (703 aa)
BARHL2BarH like homeobox 2. (384 aa)
EFNA1Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
LARP6La ribonucleoprotein domain family member 6. (462 aa)
THBS1Uncharacterized protein. (1170 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (623 aa)
RMND1Required for meiotic nuclear division 1 homolog. (447 aa)
PINK1PTEN induced kinase 1. (588 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
GSK3AProtein kinase domain-containing protein. (566 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (649 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
AURKAAurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
SP1Transcription factor Sp1 isoform a. (786 aa)
PLD1Phospholipase. (1074 aa)
LARP1BLa ribonucleoprotein domain family member 1B. (1116 aa)
TENT5BTerminal nucleotidyltransferase 5B. (426 aa)
ZCCHC13Zinc finger CCHC-type containing 13. (171 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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