(5 nodes) Atg12-Atg5-Atg16 complex network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	ATG16L2	Autophagy related 16 like 2. (647 aa)
	WDFY3	WD repeat and FYVE domain containing 3. (3526 aa)
	ATG16L1	Autophagy-related protein 16-1 isoform X1. (623 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG16L1	ENSSSCP00000054263	ENSSSCP00000039214	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 16-1 isoform X1.	0.999
ATG12	ATG16L2	ENSSSCP00000054263	ENSSSCP00000015737	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 16 like 2.	0.990
ATG12	ATG5	ENSSSCP00000054263	ENSSSCP00000071330	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.999
ATG12	WDFY3	ENSSSCP00000054263	ENSSSCP00000009843	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat and FYVE domain containing 3.	0.684
ATG16L1	ATG12	ENSSSCP00000039214	ENSSSCP00000054263	Autophagy-related protein 16-1 isoform X1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG16L1	ATG16L2	ENSSSCP00000039214	ENSSSCP00000015737	Autophagy-related protein 16-1 isoform X1.	Autophagy related 16 like 2.	0.918
ATG16L1	ATG5	ENSSSCP00000039214	ENSSSCP00000071330	Autophagy-related protein 16-1 isoform X1.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.999
ATG16L1	WDFY3	ENSSSCP00000039214	ENSSSCP00000009843	Autophagy-related protein 16-1 isoform X1.	WD repeat and FYVE domain containing 3.	0.610
ATG16L2	ATG12	ENSSSCP00000015737	ENSSSCP00000054263	Autophagy related 16 like 2.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.990
ATG16L2	ATG16L1	ENSSSCP00000015737	ENSSSCP00000039214	Autophagy related 16 like 2.	Autophagy-related protein 16-1 isoform X1.	0.918
ATG16L2	ATG5	ENSSSCP00000015737	ENSSSCP00000071330	Autophagy related 16 like 2.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.991
ATG16L2	WDFY3	ENSSSCP00000015737	ENSSSCP00000009843	Autophagy related 16 like 2.	WD repeat and FYVE domain containing 3.	0.513
ATG5	ATG12	ENSSSCP00000071330	ENSSSCP00000054263	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG16L1	ENSSSCP00000071330	ENSSSCP00000039214	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	Autophagy-related protein 16-1 isoform X1.	0.999
ATG5	ATG16L2	ENSSSCP00000071330	ENSSSCP00000015737	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	Autophagy related 16 like 2.	0.991
ATG5	WDFY3	ENSSSCP00000071330	ENSSSCP00000009843	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	WD repeat and FYVE domain containing 3.	0.743
WDFY3	ATG12	ENSSSCP00000009843	ENSSSCP00000054263	WD repeat and FYVE domain containing 3.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.684
WDFY3	ATG16L1	ENSSSCP00000009843	ENSSSCP00000039214	WD repeat and FYVE domain containing 3.	Autophagy-related protein 16-1 isoform X1.	0.610
WDFY3	ATG16L2	ENSSSCP00000009843	ENSSSCP00000015737	WD repeat and FYVE domain containing 3.	Autophagy related 16 like 2.	0.513
WDFY3	ATG5	ENSSSCP00000009843	ENSSSCP00000071330	WD repeat and FYVE domain containing 3.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...]	0.743