node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | APOB | ENSSSCP00000046998 | ENSSSCP00000042786 | C1q domain-containing protein. | Apolipoprotein B-100. | 0.514 |
ADIPOQ | APOE | ENSSSCP00000046998 | ENSSSCP00000003343 | C1q domain-containing protein. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.604 |
ADIPOQ | CD36 | ENSSSCP00000046998 | ENSSSCP00000016332 | C1q domain-containing protein. | Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. | 0.587 |
APOA2 | APOB | ENSSSCP00000069906 | ENSSSCP00000042786 | Apolipoprotein A-II preproprotein. | Apolipoprotein B-100. | 0.965 |
APOA2 | APOC3 | ENSSSCP00000069906 | ENSSSCP00000063050 | Apolipoprotein A-II preproprotein. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.989 |
APOA2 | APOE | ENSSSCP00000069906 | ENSSSCP00000003343 | Apolipoprotein A-II preproprotein. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.952 |
APOA2 | APOM | ENSSSCP00000069906 | ENSSSCP00000048219 | Apolipoprotein A-II preproprotein. | Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). | 0.862 |
APOA2 | LDLR | ENSSSCP00000069906 | ENSSSCP00000070219 | Apolipoprotein A-II preproprotein. | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. | 0.550 |
APOA2 | SCARB1 | ENSSSCP00000069906 | ENSSSCP00000010421 | Apolipoprotein A-II preproprotein. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. | 0.576 |
APOA2 | VLDLR | ENSSSCP00000069906 | ENSSSCP00000053392 | Apolipoprotein A-II preproprotein. | Very low density lipoprotein receptor. | 0.590 |
APOB | ADIPOQ | ENSSSCP00000042786 | ENSSSCP00000046998 | Apolipoprotein B-100. | C1q domain-containing protein. | 0.514 |
APOB | APOA2 | ENSSSCP00000042786 | ENSSSCP00000069906 | Apolipoprotein B-100. | Apolipoprotein A-II preproprotein. | 0.965 |
APOB | APOC3 | ENSSSCP00000042786 | ENSSSCP00000063050 | Apolipoprotein B-100. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.987 |
APOB | APOE | ENSSSCP00000042786 | ENSSSCP00000003343 | Apolipoprotein B-100. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.988 |
APOB | APOM | ENSSSCP00000042786 | ENSSSCP00000048219 | Apolipoprotein B-100. | Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). | 0.757 |
APOB | CD36 | ENSSSCP00000042786 | ENSSSCP00000016332 | Apolipoprotein B-100. | Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. | 0.502 |
APOB | LDLR | ENSSSCP00000042786 | ENSSSCP00000070219 | Apolipoprotein B-100. | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. | 0.696 |
APOB | LDLRAP1 | ENSSSCP00000042786 | ENSSSCP00000066253 | Apolipoprotein B-100. | Low density lipoprotein receptor adaptor protein 1. | 0.859 |
APOB | MSR1 | ENSSSCP00000042786 | ENSSSCP00000007437 | Apolipoprotein B-100. | Macrophage scavenger receptor 1. | 0.730 |
APOB | SCARB1 | ENSSSCP00000042786 | ENSSSCP00000010421 | Apolipoprotein B-100. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. | 0.932 |