STRINGSTRING
NUP214 NUP214 SNUPN SNUPN TPR TPR BCL3 BCL3 NOP53 NOP53 IPO13 IPO13 KPNA3 KPNA3 KPNA2 KPNA2 PHB2 PHB2 CSE1L CSE1L HIKESHI HIKESHI RANBP2 RANBP2 PIK3R1 PIK3R1 OSBPL8 OSBPL8 PLK1 PLK1 TOR1AIP2 TOR1AIP2 FAM53C FAM53C SPG11 SPG11 TBRG1 TBRG1 KPNA1 KPNA1 GCKR GCKR NUP62CL NUP62CL CDK5 CDK5 WRAP53 WRAP53 CTDNEP1 CTDNEP1 NF1 NF1 MED1 MED1 NUP50 NUP50 IPO8 IPO8 LRRK2 LRRK2 APPL2 APPL2 CDKN1A CDKN1A PML PML NFKBIA NFKBIA ARL2BP ARL2BP DVL1 DVL1 PARK7 PARK7 KPNA5 KPNA5 TRAF3IP2 TRAF3IP2 PYGO1 PYGO1 BMP4 BMP4 SIX1 SIX1 RANBP6 RANBP6 XPA XPA CIZ1 CIZ1 RRS1 RRS1 NXT1 NXT1 BMP7 BMP7 KPNA7 KPNA7 NOL8 NOL8 SIX2 SIX2 SUPT7L SUPT7L MSX1 MSX1 NUP54 NUP54 PPP3CA PPP3CA FAM53B FAM53B TAF3 TAF3 CLDN18 CLDN18 POLA2 POLA2 CRY2 CRY2 STK11 STK11 ELAVL1 ELAVL1 TNPO2 TNPO2 CALR CALR LMNB1 LMNB1 TMCO6 TMCO6 UTP25 UTP25 WRN WRN SHH SHH SMO SMO GLI3 GLI3 F1SRM6_PIG F1SRM6_PIG NUP85 NUP85 SOX9 SOX9 STAT3 STAT3 MORC3 MORC3 SEC13 SEC13 STK4 STK4 IPO5 IPO5 A0A5G2R996_PIG A0A5G2R996_PIG RAN RAN IPO4 IPO4 RANGAP1 RANGAP1 RPF2 RPF2 KPNB1 KPNB1 RPAIN RPAIN LOC102162368 LOC102162368 IPO11 IPO11 A0A5G2R752_PIG A0A5G2R752_PIG A0A5G2QNQ5_PIG A0A5G2QNQ5_PIG COL1A1 COL1A1 BBS4 BBS4 NUP35 NUP35 PAF1 PAF1 RRP7A RRP7A NUP153 NUP153 BANP BANP NUP107 NUP107 SYNE1 SYNE1 A0A5G2QD71_PIG A0A5G2QD71_PIG HEATR3 HEATR3 GPN3 GPN3 POM121L2 POM121L2 PPP3R1 PPP3R1 ING1 ING1 FGF9 FGF9 AKIRIN2 AKIRIN2 RPL11 RPL11 KPNA6 KPNA6 A0A287BRG1_PIG A0A287BRG1_PIG TNPO3 TNPO3 NUP188 NUP188 E2F3 E2F3 TOR1A TOR1A SQSTM1 SQSTM1 CNEP1R1 CNEP1R1 ATF2 ATF2 TOR1AIP1 TOR1AIP1 TP53 TP53 TAF8 TAF8 ARL2 ARL2 IPO7 IPO7 NOTCH1 NOTCH1 SHISA4 SHISA4 NUP62 NUP62 RANGRF RANGRF FAM53A FAM53A NR5A1 NR5A1 STK3 STK3 LMNA LMNA TNPO1 TNPO1 KPNA4 KPNA4 NXT2 NXT2 TOPORS TOPORS IPO9 IPO9 SUN1 SUN1 PINX1 PINX1 PRICKLE1 PRICKLE1 RAP1GDS1 RAP1GDS1 NUP133 NUP133 LMNB2 LMNB2 POM121C POM121C NUP93 NUP93 ZBTB7A ZBTB7A NUP155 NUP155 APPL1 APPL1 ABCA7 ABCA7 NUTF2 NUTF2 EIF4ENIF1 EIF4ENIF1 INTS13 INTS13 HNRNPU HNRNPU SIX4 SIX4 TXNIP TXNIP ABRA ABRA XPO1 XPO1 NUP88 NUP88 SYK SYK A0A286ZN03_PIG A0A286ZN03_PIG HHEX HHEX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUP214Nucleoporin 214. (2016 aa)
SNUPNSnurportin 1. (386 aa)
TPRTranslocated promoter region, nuclear basket protein. (2518 aa)
BCL3ANK_REP_REGION domain-containing protein. (453 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (470 aa)
IPO13Importin-13. (963 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
PHB2Prohibitin. (299 aa)
CSE1LChromosome segregation 1 like. (973 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
RANBP2RAN binding protein 2. (3233 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
TOR1AIP2Torsin 1A interacting protein 2. (531 aa)
FAM53CFamily with sequence similarity 53 member C. (389 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2467 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
KPNA1IBB domain-containing protein. (648 aa)
GCKRGlucokinase regulator. (641 aa)
NUP62CLNucleoporin 62 C-terminal like. (183 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
WRAP53WD repeat containing antisense to TP53. (539 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
NF1Neurofibromin 1. (2847 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
NUP50Nucleoporin 50. (440 aa)
IPO8Importin 8. (1037 aa)
LRRK2Uncharacterized protein. (2501 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
PMLPromyelocytic leukemia. (827 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (175 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
PARK7DJ-1 protein. (189 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
TRAF3IP2TRAF3 interacting protein 2. (574 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX1Six homeobox 1. (284 aa)
RANBP6Ran-binding protein 6 isoform X1. (1105 aa)
XPAXPA, DNA damage recognition and repair factor. (310 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (758 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
KPNA7Importin subunit alpha-8; Functions in nuclear protein import. (507 aa)
NOL8Nucleolar protein 8. (1123 aa)
SIX2SIX homeobox 2. (296 aa)
SUPT7LSTAGA complex 65 subunit gamma isoform b. (412 aa)
MSX1Homeobox domain-containing protein. (303 aa)
NUP54Nucleoporin 54. (564 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
FAM53BFamily with sequence similarity 53 member B. (430 aa)
TAF3TATA-box binding protein associated factor 3. (929 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa)
CRY2Cryptochrome circadian regulator 2. (615 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
TNPO2Transportin 2. (913 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa)
LMNB1Lamin-B1 isoform 1; Belongs to the intermediate filament family. (586 aa)
TMCO6Transmembrane and coiled-coil domains 6. (517 aa)
UTP25UTP25 small subunit processor component. (760 aa)
WRNWRN RecQ like helicase. (1466 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
GLI3GLI family zinc finger 3. (1586 aa)
F1SRM6_PIGUncharacterized protein. (954 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (684 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
MORC3MORC family CW-type zinc finger 3. (939 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (341 aa)
STK4Serine/threonine kinase 4. (502 aa)
IPO5Importin N-terminal domain-containing protein. (1127 aa)
A0A5G2R996_PIGKASH domain-containing protein. (999 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (222 aa)
IPO4Importin 4. (1153 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
RPF2Ribosome production factor 2 homolog. (306 aa)
KPNB1Karyopherin subunit beta 1. (877 aa)
RPAINRPA interacting protein. (230 aa)
LOC102162368Uncharacterized protein. (313 aa)
IPO11Importin 11. (975 aa)
A0A5G2R752_PIGDUF775 domain-containing protein. (196 aa)
A0A5G2QNQ5_PIGUncharacterized protein. (428 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
BBS4Uncharacterized protein. (826 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (327 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (560 aa)
RRP7ARibosomal RNA processing 7 homolog A. (412 aa)
NUP153Nucleoporin 153. (1473 aa)
BANPBEN domain-containing protein. (505 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
SYNE1Uncharacterized protein. (1723 aa)
A0A5G2QD71_PIGGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (138 aa)
HEATR3HEAT repeat containing 3. (728 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (323 aa)
POM121L2Uncharacterized protein. (451 aa)
PPP3R1Uncharacterized protein. (188 aa)
ING1Inhibitor of growth protein. (299 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
AKIRIN2Akirin 2. (213 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (192 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (578 aa)
A0A287BRG1_PIGUncharacterized protein. (210 aa)
TNPO3Transportin 3. (957 aa)
NUP188Nucleoporin 188. (1769 aa)
E2F3E2F transcription factor 3. (466 aa)
TOR1ATorsin. (333 aa)
SQSTM1Sequestosome 1. (451 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (114 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TOR1AIP1Torsin 1A interacting protein 1. (590 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
TAF8TATA-box binding protein associated factor 8. (320 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family. (211 aa)
IPO7Importin 7. (1068 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
SHISA4Shisa family member 4. (297 aa)
NUP62Nucleoporin 62. (478 aa)
RANGRFRan guanine nucleotide release factor isoform A. (182 aa)
FAM53AFamily with sequence similarity 53 member A. (359 aa)
NR5A1Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] (461 aa)
STK3Serine/threonine kinase 3. (542 aa)
LMNAPrelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] (704 aa)
TNPO1Transportin 1. (898 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
NXT2Nuclear transport factor 2 like export factor 2. (198 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1049 aa)
IPO9Importin 9. (1080 aa)
SUN1Sad1 and UNC84 domain containing 1. (848 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1 isoform 1. (313 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (606 aa)
NUP133Nucleoporin 133. (1160 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (742 aa)
POM121CUncharacterized protein. (1193 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (797 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (596 aa)
NUP155Nucleoporin 155. (1391 aa)
APPL1Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa)
ABCA7ATP binding cassette subfamily A member 7. (2206 aa)
NUTF2Nuclear transport factor 2. (103 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (984 aa)
INTS13Protein asunder homolog isoform X1. (706 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
SIX4Homeobox domain-containing protein. (785 aa)
TXNIPThioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] (391 aa)
ABRAActin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. (384 aa)
XPO1Exportin 1. (1071 aa)
NUP88Nucleoporin 88. (739 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
A0A286ZN03_PIGRibosomal_L5 domain-containing protein. (174 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (269 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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