STRINGSTRING
HECW1 HECW1 A0A287B5K4_PIG A0A287B5K4_PIG KCNE5 KCNE5 AKT1 AKT1 DRD2 DRD2 OAZ3 OAZ3 MMP9 MMP9 UBQLN1 UBQLN1 KCNE3 KCNE3 A0A287AUC1_PIG A0A287AUC1_PIG PEA15 PEA15 A0A287ABS1_PIG A0A287ABS1_PIG APPL2 APPL2 GSK3A GSK3A EPHB2 EPHB2 THBS1 THBS1 CASQ2 CASQ2 STXBP3 STXBP3 EPO EPO COMMD1 COMMD1 FKBP1B FKBP1B F1S145_PIG F1S145_PIG PKD2 PKD2 KCNRG KCNRG PPIF PPIF ADRA2A ADRA2A TLR9 TLR9 DRD3 DRD3 KCNE1 KCNE1 DRD4 DRD4 CBARP CBARP SRI SRI SESTD1 SESTD1 AKT2 AKT2 GRP GRP MRLN MRLN ARL6IP5 ARL6IP5 REM2 REM2 HAMP HAMP LOC110257570 LOC110257570 FABP5 FABP5 GOPC GOPC PCSK9 PCSK9 INPP5K INPP5K GEM GEM GRB10 GRB10 GNB5 GNB5 CAV1 CAV1 ACTN2 ACTN2 RSC1A1 RSC1A1 KCNE4 KCNE4 PID1 PID1 CXH4orf3 CXH4orf3 KCNAB1 KCNAB1 SLC30A1 SLC30A1 LOC100737265 LOC100737265 LEP LEP SLC43A2 SLC43A2 ENPP1 ENPP1 OSTN OSTN KCNH2 KCNH2 OSR1 OSR1 PRKCB PRKCB OAZ2 OAZ2 OXSR1 OXSR1 STK39 STK39 REM1 REM1 KEL KEL CALM3 CALM3 NEDD4L NEDD4L CLIC2 CLIC2 SLC9A3R1 SLC9A3R1 NEDD4 NEDD4 RRAD RRAD CRBN CRBN ANO9 ANO9 CTTNBP2NL CTTNBP2NL IRS2 IRS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1602 aa)
A0A287B5K4_PIGProtein kinase domain-containing protein. (62 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (145 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa)
OAZ3Ornithine decarboxylase antizyme 3. (186 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
UBQLN1Ubiquilin 1. (582 aa)
KCNE3Potassium voltage-gated channel subfamily E member 3 isoform X1. (99 aa)
A0A287AUC1_PIGEF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (157 aa)
A0A287ABS1_PIGUncharacterized protein. (178 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
GSK3AProtein kinase domain-containing protein. (566 aa)
EPHB2EPH receptor B2. (987 aa)
THBS1Uncharacterized protein. (1170 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (405 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
COMMD1Copper metabolism domain containing 1. (189 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
F1S145_PIGUncharacterized protein; Belongs to the calmodulin family. (196 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
KCNRGPotassium channel regulatory protein isoform 1. (274 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (237 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CBARPUncharacterized protein. (894 aa)
SRISorcin isoform A. (199 aa)
SESTD1SEC14 and spectrin domain containing 1. (722 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (146 aa)
MRLNUncharacterized protein. (46 aa)
ARL6IP5PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity- dependent manner. May be involved in membrane traffic. (202 aa)
REM2RRAD and GEM like GTPase 2. (343 aa)
HAMPHepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa)
LOC110257570TRPM8 channel-associated factor 2 isoform X1. (920 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (235 aa)
GOPCPDZ domain-containing protein. (463 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (480 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
GNB5G protein subunit beta 5. (420 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
ACTN2Uncharacterized protein. (933 aa)
RSC1A1Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). (1028 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (191 aa)
PID1PID domain-containing protein. (223 aa)
CXH4orf3Uncharacterized protein. (69 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (419 aa)
SLC30A1Solute carrier family 30 member 1. (506 aa)
LOC100737265Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
SLC43A2Solute carrier family 43 member 2. (572 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
OSTNMusclin. (132 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (1163 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
OAZ2Ornithine decarboxylase antizyme 2. (187 aa)
OXSR1Serine/threonine-protein kinase OSR1; Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (545 aa)
STK39Serine/threonine kinase 39. (582 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (314 aa)
KELKell metallo-endopeptidase (Kell blood group). (763 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1265 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (259 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CRBNCereblon. (444 aa)
ANO9Anoctamin. (786 aa)
CTTNBP2NLCTTNBP2 N-terminal-like protein isoform X1. (639 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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