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| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa) |
| | EDEM3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (949 aa) |
| | TMEM117 | Transmembrane protein 117 isoform X1. (514 aa) |
| | NPLOC4 | NPL4 homolog, ubiquitin recognition factor. (782 aa) |
| | BHLHA15 | Basic helix-loop-helix family member a15. (234 aa) |
| | TMCO1 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Belongs to the TMCO1 family. (246 aa) |
| | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1. (1613 aa) |
| | PDX1 | Homeobox domain-containing protein. (284 aa) |
| | FBXO17 | F-box protein 17. (295 aa) |
| | DNAJC18 | DnaJ heat shock protein family (Hsp40) member C18. (358 aa) |
| | RHBDD1 | Rhomboid-related protein 4 isoform X1. (322 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (889 aa) |
| | JKAMP | JNK1/MAPK8 associated membrane protein. (325 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa) |
| | HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (389 aa) |
| | TMUB2 | Transmembrane and ubiquitin like domain containing 2. (322 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa) |
| | ATF4 | Activating transcription factor 4. (329 aa) |
| | DDRGK1 | DDRGK domain-containing protein 1. (312 aa) |
| | TOR1A | Torsin. (333 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (373 aa) |
| | RHBDD2 | Rhomboid domain containing 2. (364 aa) |
| | MARCKS | Myristoylated alanine rich protein kinase C substrate. (332 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | VAPB | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa) |
| | ERLIN2 | ER lipid raft associated 2. (384 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | GET4 | Uncharacterized protein. (668 aa) |
| | ATF6 | Activating transcription factor 6. (680 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa) |
| | GORASP2 | Golgi reassembly stacking protein 2. (451 aa) |
| | UBXN4 | UBX domain-containing protein 4. (508 aa) |
| | UBA5 | Ubiquitin like modifier activating enzyme 5. (447 aa) |
| | UBE2J2 | Ubiquitin-conjugating enzyme E2 J2. (259 aa) |
| | UBE4A | U-box domain-containing protein. (1074 aa) |
| | TRIM13 | E3 ubiquitin-protein ligase TRIM13 isoform 2. (407 aa) |
| | A0A5G2QH53_PIG | F-box domain-containing protein. (90 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (656 aa) |
| | SESN2 | Sestrin 2. (471 aa) |
| | NCCRP1 | Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (334 aa) |
| | SGTA | Small glutamine rich tetratricopeptide repeat containing alpha. (394 aa) |
| | RNF121 | Ring finger protein 121. (328 aa) |
| | EDEM2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa) |
| | TRIM25 | Tripartite motif containing 25. (633 aa) |
| | ERP44 | Thioredoxin domain-containing protein. (460 aa) |
| | P4HB | Protein disulfide-isomerase. (623 aa) |
| | BRIX1 | Uncharacterized protein. (404 aa) |
| | SCAMP5 | Secretory carrier-associated membrane protein. (252 aa) |
| | TMX1 | Thioredoxin-related transmembrane protein 1. (278 aa) |
| | BBC3 | Uncharacterized protein. (361 aa) |
| | ERLEC1 | Endoplasmic reticulum lectin 1. (487 aa) |
| | DNAJB2 | DnaJ heat shock protein family (Hsp40) member B2. (334 aa) |
| | FAF1 | Fas associated factor 1. (657 aa) |
| | UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1. (1565 aa) |
| | HERPUD2 | HERPUD family member 2. (435 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (513 aa) |
| | MARCHF6 | Membrane associated ring-CH-type finger 6. (910 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (520 aa) |
| | TMEM67 | Transmembrane protein 67. (974 aa) |
| | A0A287AB25_PIG | Uncharacterized protein. (292 aa) |
| | FBXO2 | F-box protein 2. (322 aa) |
| | OS9 | OS9 endoplasmic reticulum lectin. (665 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1364 aa) |
| | MAN1B1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (652 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa) |
| | TMTC3 | Transmembrane O-mannosyltransferase targeting cadherins 3. (939 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (338 aa) |
| | TMTC4 | Transmembrane O-mannosyltransferase targeting cadherins 4. (762 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa) |
| | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10. (803 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (1055 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa) |
| | TMEM33 | Transmembrane protein 33. (326 aa) |
| | TBL2 | Transducin beta like 2. (465 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1270 aa) |
| | UBQLN2 | Ubiquilin 2. (576 aa) |
| | A0A286ZW56_PIG | Uncharacterized protein. (277 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] (878 aa) |
| | SYVN1 | Synoviolin 1. (613 aa) |
| | EDEM1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (636 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1425 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1020 aa) |
| | SGTB | Small glutamine rich tetratricopeptide repeat containing beta. (300 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa) |
| | FAF2 | Fas associated factor family member 2. (445 aa) |
| | TTC33 | Tetratricopeptide repeat domain 33. (364 aa) |
| | BAK1 | Uncharacterized protein. (266 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (989 aa) |
| | SERP2 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (373 aa) |
| | SERP1 | Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa) |
| | ATF6B | Activating transcription factor 6 beta. (717 aa) |
| | NIBAN1 | Protein Niban. (934 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa) |
| | BCAP31 | B-cell receptor-associated protein 31 isoform b. (246 aa) |
| | SRPX | Sushi repeat containing protein X-linked. (461 aa) |
| | UFL1 | E3 UFM1-protein ligase 1. (792 aa) |
| | RNF139 | E3 ubiquitin-protein ligase RNF139. (665 aa) |
| | CLGN | Calmegin. (610 aa) |
| | TMUB1 | Ubiquitin-like domain-containing protein. (328 aa) |
| | SEL1L3 | SEL1L family member 3. (1052 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | RCN3 | Reticulocalbin 3. (335 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | UBE2G2 | Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (202 aa) |
| | LOC110258087 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (646 aa) |
| | PPP1R15B | Protein phosphatase 1 regulatory subunit 15B. (709 aa) |
| | RNF183 | Ring finger protein 183. (245 aa) |
| | CERT1 | Ceramide transporter 1. (562 aa) |
| | EIF2B5 | Eukaryotic translation initiation factor 2B subunit epsilon. (702 aa) |
| | ATG10 | Autophagy related 10. (330 aa) |
| | DNAJC3 | Uncharacterized protein. (504 aa) |
| | TMX4 | Uncharacterized protein. (360 aa) |
| | I3LAM0_PIG | Uncharacterized protein. (600 aa) |
| | CCDC47 | Coiled-coil domain-containing protein 47. (483 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | THBS4 | Thrombospondin 4. (976 aa) |
| | ERN1 | Uncharacterized protein. (1029 aa) |
| | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9. (223 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | UBXN8 | UBX domain-containing protein 8 isoform 1. (276 aa) |
| | ATF3 | Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa) |
| | FOXRED2 | FAD-dependent oxidoreductase domain-containing protein 2. (687 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) |
| | NCK2 | Cytoplasmic protein. (376 aa) |
| | PDIA4 | Protein disulfide-isomerase. (646 aa) |
| | CALR3 | Calreticulin. (384 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (493 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa) |
| | STT3B | STT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa) |
| | DNAJB12 | DnaJ heat shock protein family (Hsp40) member B12. (378 aa) |
| | FICD | Adenosine monophosphate-protein transferase FICD. (458 aa) |
| | UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2. (1620 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa) |
| | PDIA6 | Uncharacterized protein; Belongs to the protein disulfide isomerase family. (590 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (409 aa) |
| | RNF103 | E3 ubiquitin-protein ligase RNF103 isoform 1. (685 aa) |
| | BCL2L11 | Uncharacterized protein. (433 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | ANKS4B | Ankyrin repeat and sterile alpha motif domain containing 4B. (417 aa) |
| | SEL1L2 | SEL1L2 adaptor subunit of ERAD E3 ligase. (687 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | FAM214B | Family with sequence similarity 214 member B. (534 aa) |
| | PARP16 | Poly [ADP-ribose] polymerase. (322 aa) |
| | SELENOS | Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). (190 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | PDIA3 | Protein disulfide-isomerase. (504 aa) |
| | MAN1A1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). (837 aa) |
| | UBXN10 | UBX domain-containing protein 10 isoform X1. (280 aa) |
| | UBE4B | Ubiquitination factor E4B. (1297 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (654 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | F1RI37_PIG | Uncharacterized protein. (284 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1257 aa) |
| | RNF5 | E3 ubiquitin-protein ligase RNF5. (180 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | FAM8A1 | Family with sequence similarity 8 member A1. (415 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa) |
| | ERP27 | Endoplasmic reticulum protein 27. (272 aa) |
| | UBE2J1 | Ubiquitin-conjugating enzyme E2 J1. (318 aa) |
| | AMFR | Autocrine motility factor receptor. (731 aa) |
| | HM13 | Histocompatibility minor 13. (449 aa) |
| | DDIT3 | DNA-damage-inducible transcript 3. (167 aa) |
| | YOD1 | YOD1 deubiquitinase. (306 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa) |
| | DNAJB14 | DnaJ heat shock protein family (Hsp40) member B14. (379 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | ECPAS | Ecm29 proteasome adaptor and scaffold. (1849 aa) |
| | FAM214A | Family with sequence similarity 214 member A. (1091 aa) |
| | TMEM259 | Transmembrane protein 259. (770 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1633 aa) |
| | CANX | Calnexin. (615 aa) |
| | UBXN6 | UBX domain protein 6. (546 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | UBQLN1 | Ubiquilin 1. (582 aa) |
| | RNF186 | Ring finger protein 186. (191 aa) |
| | A0A287B1R4_PIG | Uncharacterized protein. (34 aa) |
| | NRBF2 | Nuclear receptor binding factor 2. (288 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | ANKZF1 | Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (722 aa) |
| | ERO1A | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] (486 aa) |
