STRINGSTRING
SFRP2 SFRP2 FREM2 FREM2 TBX3 TBX3 TBX5 TBX5 HNF1A HNF1A ATRX ATRX ZIC3 ZIC3 FGF4 FGF4 LRP5 LRP5 C2CD3 C2CD3 FLVCR1 FLVCR1 EN1 EN1 HOXD13 HOXD13 HOXD12 HOXD12 HOXD10 HOXD10 HOXD9 HOXD9 IHH IHH SHH SHH HOXA11 HOXA11 GLI3 GLI3 CPLANE1 CPLANE1 FGF10 FGF10 SOX9 SOX9 MED1 MED1 SULF1 SULF1 FZD6 FZD6 OSR2 OSR2 TULP3 TULP3 PSEN1 PSEN1 EXT1 EXT1 ALDH1A2 ALDH1A2 GRHL2 GRHL2 RUNX2 RUNX2 FRAS1 FRAS1 FGF8 FGF8 FBN2 FBN2 MAP3K20 MAP3K20 TP63 TP63 RECK RECK RNF165 RNF165 FGF9 FGF9 ALX3 ALX3 DLX6 DLX6 LNPK LNPK LMBR1 LMBR1 PCSK5 PCSK5 HAND2 HAND2 INTU INTU B9D1 B9D1 NIPBL NIPBL CHST11 CHST11 NOG NOG FMN1 FMN1 TFAP2A TFAP2A SP8 SP8 NOTCH1 NOTCH1 IFT52 IFT52 WNT3 WNT3 GNA12 GNA12 DLX5 DLX5 LRP4 LRP4 IMPAD1 IMPAD1 BMPR1A BMPR1A TFAP2B TFAP2B GREM1 GREM1 WNT5A WNT5A PRRX1 PRRX1 ALX4 ALX4 COL2A1 COL2A1 OSR1 OSR1 ZNF219 ZNF219 RDH10 RDH10 PITX1 PITX1 SP9 SP9 ZBTB16 ZBTB16 LEF1 LEF1 COL3A1 COL3A1 BAK1 BAK1 RARG RARG RPGRIP1L RPGRIP1L CTNNB1 CTNNB1 GPC3 GPC3 GNAS GNAS PTCH1 PTCH1 TMEM107 TMEM107 TBX4 TBX4 HOXC10 HOXC10 HOXA13 HOXA13 HOXC11 HOXC11 WDR19 WDR19 GDF5 GDF5 EVX2 EVX2 HDAC1 HDAC1 HOXA9 HOXA9 SEMA3C SEMA3C TBX2 TBX2 PLXNA2 PLXNA2 SHOX2 SHOX2 MKS1 MKS1 CHD7 CHD7 BMP4 BMP4 SMAD4 SMAD4 TBC1D32 TBC1D32 ECE1 ECE1 BAX BAX MEGF8 MEGF8 SALL1 SALL1 TMEM231 TMEM231 CRABP2 CRABP2 NOTCH2 NOTCH2 BMP7 BMP7 IFT140 IFT140 BCL2L11 BCL2L11 CYP26B1 CYP26B1 PKDCC PKDCC MSX1 MSX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP2Uncharacterized protein. (294 aa)
FREM2FRAS1 related extracellular matrix 2. (3174 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
TBX5T-box transcription factor 5. (535 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform 2. (631 aa)
ATRXATRX chromatin remodeler. (2486 aa)
ZIC3Zic family member 3. (467 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1. (559 aa)
EN1Homeobox protein engrailed-like. (367 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
HOXD12Homeobox protein Hox-D12. (270 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
HOXD9Homeobox D9. (351 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
GLI3GLI family zinc finger 3. (1586 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3098 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
SULF1Sulfatase 1. (1108 aa)
FZD6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (472 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (527 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4013 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FBN2Fibrillin 2. (2910 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (799 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs isoform 1. (971 aa)
RNF165Ring finger protein 165. (365 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
ALX3ALX homeobox 3. (362 aa)
DLX6Distal-less homeobox 6. (333 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
LMBR1Limb region 1 protein homolog isoform b; Belongs to the LIMR family. (490 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1886 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
INTUInturned planar cell polarity protein. (937 aa)
B9D1B9 domain containing 1. (204 aa)
NIPBLNipped-B protein. (2804 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FMN1Formin 1. (1195 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
SP8Sp8 transcription factor. (504 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
GNA12G protein subunit alpha 12. (382 aa)
DLX5Homeobox protein DLX-5. (290 aa)
LRP4LDL receptor related protein 4. (1918 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
ALX4ALX homeobox 4. (406 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
ZNF219Zinc finger protein 219. (716 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PITX1Homeobox protein. (314 aa)
SP9Sp9 transcription factor. (485 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
BAK1Uncharacterized protein. (266 aa)
RARGRetinoic acid receptor gamma. (554 aa)
RPGRIP1LProtein fantom isoform X1. (1270 aa)
CTNNB1Catenin beta 1. (808 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
GNASGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
TMEM107Transmembrane protein 107 isoform 2. (140 aa)
TBX4Uncharacterized protein. (549 aa)
HOXC10Homeobox C10. (342 aa)
HOXA13Homeobox A13. (388 aa)
HOXC11Homeobox C11. (304 aa)
WDR19WD repeat domain 19. (1342 aa)
GDF5Growth differentiation factor 5. (499 aa)
EVX2Even-skipped homeobox 2. (474 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
SEMA3CSemaphorin-3C isoform 2; Belongs to the semaphorin family. (751 aa)
TBX2T-box 2 protein. (714 aa)
PLXNA2Plexin A2. (1937 aa)
SHOX2Short stature homeobox 2. (321 aa)
MKS1MKS transition zone complex subunit 1. (557 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
TBC1D32Protein broad-minded isoform X1. (1300 aa)
ECE1Endothelin converting enzyme 1. (771 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
SALL1Spalt like transcription factor 1. (1326 aa)
TMEM231Transmembrane protein 231. (318 aa)
CRABP2FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
IFT140Intraflagellar transport 140. (1477 aa)
BCL2L11Uncharacterized protein. (433 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
MSX1Homeobox domain-containing protein. (303 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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