(19 nodes) Megakaryocyte development network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (650 aa)
	SRF	Serum response factor. (512 aa)
	SH2B3	SH2B adaptor protein 3. (600 aa)
	ABI1	Abl interactor 1 isoform b. (481 aa)
	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
	EP300	E1A binding protein p300. (2420 aa)
	WASF2	Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
	THPO	Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (477 aa)
	MPIG6B	Ig-like domain-containing protein. (328 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
	FLI1	Fli-1 proto-oncogene, ETS transcription factor. (480 aa)
	GP9	Glycoprotein IX platelet. (173 aa)
	MEIS1	Homeobox protein Meis1. (465 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (965 aa)
	ZNF385A	Zinc finger protein 385A. (406 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	WASF2	ENSSSCP00000011798	ENSSSCP00000023179	Abl interactor 1 isoform b.	Wiskott-Aldrich syndrome protein family member 2 isoform 2.	0.914
EP300	MED1	ENSSSCP00000020812	ENSSSCP00000018552	E1A binding protein p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.847
EP300	TAL1	ENSSSCP00000020812	ENSSSCP00000036253	E1A binding protein p300.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.493
EP300	ZFPM1	ENSSSCP00000020812	ENSSSCP00000049549	E1A binding protein p300.	Zinc finger protein, FOG family member 1.	0.598
KIT	PTPN11	ENSSSCP00000066488	ENSSSCP00000064345	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.962
KIT	PTPN6	ENSSSCP00000066488	ENSSSCP00000036336	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.412
MED1	EP300	ENSSSCP00000018552	ENSSSCP00000020812	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	E1A binding protein p300.	0.847
MEIS1	SRF	ENSSSCP00000039750	ENSSSCP00000001805	Homeobox protein Meis1.	Serum response factor.	0.480
MPIG6B	PTPN11	ENSSSCP00000035146	ENSSSCP00000064345	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.793
MPIG6B	PTPN6	ENSSSCP00000035146	ENSSSCP00000036336	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.770
PTPN11	KIT	ENSSSCP00000064345	ENSSSCP00000066488	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.962
PTPN11	MPIG6B	ENSSSCP00000064345	ENSSSCP00000035146	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.793
PTPN11	PTPN6	ENSSSCP00000064345	ENSSSCP00000036336	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.911
PTPN6	KIT	ENSSSCP00000036336	ENSSSCP00000066488	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.412
PTPN6	MPIG6B	ENSSSCP00000036336	ENSSSCP00000035146	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.770
PTPN6	PTPN11	ENSSSCP00000036336	ENSSSCP00000064345	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.911
PTPN6	SH2B3	ENSSSCP00000036336	ENSSSCP00000010497	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	SH2B adaptor protein 3.	0.404
SH2B3	PTPN6	ENSSSCP00000010497	ENSSSCP00000036336	SH2B adaptor protein 3.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.404
SRF	MEIS1	ENSSSCP00000001805	ENSSSCP00000039750	Serum response factor.	Homeobox protein Meis1.	0.480
TAL1	EP300	ENSSSCP00000036253	ENSSSCP00000020812	TAL bHLH transcription factor 1, erythroid differentiation factor.	E1A binding protein p300.	0.493