STRINGSTRING
CTR9 CTR9 NR0B1 NR0B1 COL7A1 COL7A1 COL4A2 COL4A2 SOX17 SOX17 LOC100359361 LOC100359361 COL12A1 COL12A1 MMP2 MMP2 COL11A1 COL11A1 COL8A1 COL8A1 COL6A1 COL6A1 PAF1 PAF1 MMP9 MMP9 ITGB5 ITGB5 MMP15 MMP15 INHBA INHBA SETD2 SETD2 MAP2K1 MAP2K1 HMGA2 HMGA2 LAMA3 LAMA3 GATA6 GATA6 POU5F1 POU5F1 ITGA5 ITGA5 ITGA7 ITGA7 ITGA4 ITGA4 LEO1 LEO1 NODAL NODAL EOMES EOMES CTNNB1 CTNNB1 ITGAV ITGAV MIXL1 MIXL1 RTF1 RTF1 MMP14 MMP14 VTN VTN GRB2 GRB2 LAMB3 LAMB3 LAMB1 LAMB1 MMP8 MMP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1169 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (490 aa)
COL7A1Uncharacterized protein. (2938 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
SOX17SRY-box transcription factor 17. (407 aa)
LOC100359361Uncharacterized protein. (108 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
MMP2Uncharacterized protein. (610 aa)
COL11A1Collagen type XI alpha 1 chain. (1816 aa)
COL8A1Collagen type VIII alpha 1 chain. (759 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (560 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
MMP15Matrix metallopeptidase 15. (712 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2557 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HMGA2Uncharacterized protein. (143 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1055 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
NODALNodal growth differentiation factor. (316 aa)
EOMESEomesodermin. (704 aa)
CTNNB1Catenin beta 1. (808 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
MIXL1Mix paired-like homeobox. (237 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (769 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
MMP8Matrix metallopeptidase 8. (468 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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