STRINGSTRING
SERPINE2 SERPINE2 PPARA PPARA ACVRL1 ACVRL1 ITGA5 ITGA5 VWF VWF ADIPOR2 ADIPOR2 ANO6 ANO6 DSP DSP LRRC1 LRRC1 PPARD PPARD CDKN1A CDKN1A TREML1 TREML1 PTK7 PTK7 SRF SRF ARHGAP35 ARHGAP35 TYRO3 TYRO3 EPB41L4B EPB41L4B COL5A1 COL5A1 C8orf82 C8orf82 EXT1 EXT1 FZD6 FZD6 F5 F5 PEAR1 PEAR1 NOTCH2 NOTCH2 RHOC RHOC STXBP3 STXBP3 PPL PPL IL1A IL1A ADRA2B ADRA2B DRD5 DRD5 FGB FGB FGA FGA ANXA5 ANXA5 MMRN1 MMRN1 ARHGAP24 ARHGAP24 HPSE HPSE ODAM ODAM CCDC70 CCDC70 CPB2 CPB2 F10 F10 F7 F7 SERPIND1 SERPIND1 MYOZ1 MYOZ1 ADRA2A ADRA2A CHMP5 CHMP5 P2RY12 P2RY12 HRG HRG CHMP2B CHMP2B TIMP1 TIMP1 SYTL4 SYTL4 F9 F9 FIBP FIBP SERPING1 SERPING1 F2 F2 CD44 CD44 RAB3A RAB3A COMP COMP F2RL1 F2RL1 AP3B1 AP3B1 SMPD1 SMPD1 PRCP PRCP TFPI2 TFPI2 KLKB1 KLKB1 FZD7 FZD7 PRSS56 PRSS56 SHH SHH PPIA PPIA FGF10 FGF10 ANXA6 ANXA6 CHMP6 CHMP6 EVPL EVPL ERBB2 ERBB2 NF1 NF1 GP1BA GP1BA CD40LG CD40LG ELK3 ELK3 WNT3A WNT3A BLOC1S4 BLOC1S4 F3 F3 GATA1 GATA1 ADRA2C ADRA2C CHMP4C CHMP4C FGG FGG FGFR1OP2 FGFR1OP2 PROC PROC CHMP2A CHMP2A GP6 GP6 CHMP1A CHMP1A SLC7A11 SLC7A11 F8 F8 GP1BB GP1BB APOH APOH F2RL3 F2RL3 GP5 GP5 KDR KDR SDC1 SDC1 ALOX15 ALOX15 SLC4A1 SLC4A1 PAPSS2 PAPSS2 PAK1 PAK1 DDR1 DDR1 PDCD10 PDCD10 CAV3 CAV3 HGFAC HGFAC CHMP4A CHMP4A YAP1 YAP1 DST DST COL3A1 COL3A1 DTNBP1 DTNBP1 MPIG6B MPIG6B F2R F2R RAP2A RAP2A TGFB2 TGFB2 F11 F11 PLET1 PLET1 PTPN6 PTPN6 STXBP1 STXBP1 FGF1 FGF1 CLDN1 CLDN1 WNT5A WNT5A MERTK MERTK GP9 GP9 PROS1 PROS1 GNA13 GNA13 AXL AXL RAB27A RAB27A CHMP7 CHMP7 A0A287ADF9_PIG A0A287ADF9_PIG SLC11A1 SLC11A1 ENTPD2 ENTPD2 MACF1 MACF1 TSPAN32 TSPAN32 CNN2 CNN2 C6orf89 C6orf89 INS INS FBLN1 FBLN1 ENPP4 ENPP4 RHOA RHOA FLNA FLNA TFPI TFPI PDGFRA PDGFRA GAS6 GAS6 DCBLD2 DCBLD2 A0A287AZ68_PIG A0A287AZ68_PIG MYH1 MYH1 ARHGEF19 ARHGEF19 VKORC1 VKORC1 F2RL2 F2RL2 SYT11 SYT11 HIF1A HIF1A CORO1B CORO1B PLEC PLEC UBASH3B UBASH3B NOG NOG B4GALT1 B4GALT1 FGF2 FGF2 F12 F12 LNPK LNPK TOR1A TOR1A MYOF MYOF RAP2B RAP2B CELSR1 CELSR1 FERMT3 FERMT3 PROCR PROCR HBEGF HBEGF THBD THBD ANXA8 ANXA8 AJUBA AJUBA AQP1 AQP1 F13B F13B P2RX1 P2RX1 TRIM72 TRIM72 HPS5-2 HPS5-2 MCAM MCAM HMOX1 HMOX1 CCN1 CCN1 PLEK PLEK HNF4A HNF4A SERPINC1 SERPINC1 PLPP3 PLPP3 DYSF DYSF TMEFF2 TMEFF2 TSKU TSKU RHOB RHOB KNG1 KNG1 PLG PLG HABP2 HABP2 FKBP10 FKBP10 F13A1 F13A1 PPBP PPBP ITGB3 ITGB3 NLRP6 NLRP6 BLOC1S6 BLOC1S6 GRHL3 GRHL3 CHMP3 CHMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
PPARAUncharacterized protein. (469 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)
ADIPOR2Adiponectin receptor protein 2 isoform X1. (386 aa)
ANO6Anoctamin. (924 aa)
DSPDesmoplakin. (2883 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (310 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRFSerum response factor. (512 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (895 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
C8orf82Chromosome 8 open reading frame 82. (218 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FZD6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
F5Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1038 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
RHOCRas homolog family member C. (202 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
PPLPeriplakin. (1925 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
ADRA2BAlpha-2B adrenergic receptor. (446 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (471 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (924 aa)
ANXA5Annexin. (321 aa)
MMRN1Multimerin 1. (1220 aa)
ARHGAP24Rho GTPase activating protein 24. (749 aa)
HPSEHeparanase isoform 1 preproprotein. (551 aa)
ODAMOdontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (275 aa)
CCDC70Coiled-coil domain containing 70. (219 aa)
CPB2Carboxypeptidase B2 isoform 1 preproprotein. (423 aa)
F10Uncharacterized protein. (536 aa)
F7Uncharacterized protein. (455 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (517 aa)
MYOZ1Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). (297 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (465 aa)
CHMP5Uncharacterized protein. (219 aa)
P2RY12Purinergic receptor P2Y12. (339 aa)
HRGUncharacterized protein. (561 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
SYTL4Synaptotagmin like 4. (721 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (462 aa)
FIBPAcidic fibroblast growth factor intracellular-binding protein isoform b. (357 aa)
SERPING1Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
RAB3ARas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
F2RL1Proteinase-activated receptor 2 preproprotein. (397 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa)
PRCPProlylcarboxypeptidase. (511 aa)
TFPI2Tissue factor pathway inhibitor. (232 aa)
KLKB1Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (605 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ANXA6Annexin. (672 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
EVPLEnvoplakin. (1886 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NF1Neurofibromin 1. (2847 aa)
GP1BAPlatelet glycoprotein Ib alpha polypeptide. (627 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
ELK3ETS domain-containing protein Elk-3 isoform 1. (401 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
BLOC1S4Biogenesis of lysosomal organelles complex 1 subunit 4. (211 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
GATA1Erythroid transcription factor. (412 aa)
ADRA2CAdrenoceptor alpha 2C. (460 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
FGGFibrinogen gamma chain. (454 aa)
FGFR1OP2FGFR1 oncogene partner 2 isoform 1. (253 aa)
PROCVitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
GP6Ig-like domain-containing protein. (319 aa)
CHMP1AUncharacterized protein. (196 aa)
SLC7A11Solute carrier family 7 member 11. (515 aa)
F8Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. (2133 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (203 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GP5Glycoprotein V platelet. (569 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (309 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa)
SLC4A1Anion exchange protein. (924 aa)
PAPSS2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b. (620 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
DDR1Tyrosine-protein kinase receptor. (1005 aa)
PDCD10Programmed cell death protein 10. (212 aa)
CAV3Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa)
HGFACHGF activator. (661 aa)
CHMP4ACharged multivesicular body protein 4A. (229 aa)
YAP1Yes associated protein 1. (432 aa)
DSTDystonin. (7797 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
DTNBP1Uncharacterized protein. (373 aa)
MPIG6BIg-like domain-containing protein. (328 aa)
F2RG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
RAP2ARas-related protein Rap-2a. (183 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa)
PLET1Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). (202 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
GP9Glycoprotein IX platelet. (173 aa)
PROS1Protein S. (702 aa)
GNA13G protein subunit alpha 13. (377 aa)
AXLUncharacterized protein. (871 aa)
RAB27ARas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
CHMP7Charged multivesicular body protein 7. (505 aa)
A0A287ADF9_PIGUncharacterized protein. (80 aa)
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (538 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; Belongs to the GDA1/CD39 NTPase family. (495 aa)
MACF1Microtubule actin crosslinking factor 1. (4482 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (239 aa)
CNN2Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (396 aa)
C6orf89Chromosome 6 open reading frame 89. (470 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (819 aa)
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (453 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
FLNAFilamin A. (2897 aa)
TFPITissue factor pathway inhibitor. (303 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
GAS6Uncharacterized protein. (682 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (789 aa)
A0A287AZ68_PIGPDZ domain-containing protein. (909 aa)
MYH1Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1956 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19 isoform X1. (879 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1. (163 aa)
F2RL2Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SYT11Synaptotagmin 11. (438 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (496 aa)
PLECPlectin. (5422 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (638 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (401 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
TOR1ATorsin. (333 aa)
MYOFMyoferlin. (2182 aa)
RAP2BRas-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (183 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3320 aa)
FERMT3Fermitin family member 3. (667 aa)
PROCRProtein C receptor. (262 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
THBDUncharacterized protein. (529 aa)
ANXA8Annexin. (354 aa)
AJUBAAjuba LIM protein. (565 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
F13BCoagulation factor XIII B chain. (663 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (458 aa)
TRIM72Tripartite motif-containing protein 72. (478 aa)
HPS5-2Uncharacterized protein. (399 aa)
MCAMMelanoma cell adhesion molecule. (667 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa)
CCN1Cellular communication network factor 1. (382 aa)
PLEKPleckstrin. (408 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (505 aa)
SERPINC1SERPIN domain-containing protein; Belongs to the serpin family. (431 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
DYSFDysferlin. (2119 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (403 aa)
TSKUTsukushi, small leucine rich proteoglycan. (357 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
KNG1Kininogen 1. (630 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
HABP2Hyaluronan binding protein 2. (591 aa)
FKBP10Peptidylprolyl isomerase. (576 aa)
F13A1Coagulation factor XIII A chain. (774 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
NLRP6NLR family pyrin domain containing 6. (891 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (161 aa)
GRHL3Grainyhead like transcription factor 3. (607 aa)
CHMP3Uncharacterized protein. (251 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (24%) [HD]