42 items (Sus scrofa) - STRING interaction network

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	PRKAG1	5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
	FOXO3	Forkhead box protein O3 isoform X1. (672 aa)
	ATG14	Autophagy related 14. (510 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (402 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (545 aa)
	PRKAG3	5'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
	NIM1K	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
	BECN1	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (593 aa)
	PMAIP1	Uncharacterized protein. (121 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1095 aa)
	KPTN	Kaptin, actin binding protein. (436 aa)
	PLIN3	Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. (452 aa)
	TBL2	Transducin beta like 2. (465 aa)
	MYBBP1A	MYB binding protein 1a. (1594 aa)
	SESN3	Sestrin-3 isoform 1. (492 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3436 aa)
	C12orf66	Chromosome 12 open reading frame 66. (503 aa)
	NUAK1	NUAK family kinase 1. (666 aa)
	SIK1	Serine/threonine-protein kinase SIK1. (787 aa)
	XBP1	BZIP domain-containing protein. (378 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
	NUAK2	NUAK family kinase 2. (595 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (462 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (234 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa)
	PICK1	Protein interacting with PRKCA 1. (477 aa)
	ATF4	Activating transcription factor 4. (329 aa)
	MTMR3	Myotubularin related protein 3. (1215 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (656 aa)
	SESN2	Sestrin 2. (471 aa)
	SIK2	Salt inducible kinase 2. (949 aa)
	SESN1	Sestrin 1. (582 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
	PLIN2	Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family. (459 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (455 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNS	ATF4	ENSSSCP00000016267	ENSSSCP00000057464	Asparagine synthetase [glutamine-hydrolyzing].	Activating transcription factor 4.	0.716
ASNS	SESN2	ENSSSCP00000016267	ENSSSCP00000064491	Asparagine synthetase [glutamine-hydrolyzing].	Sestrin 2.	0.432
ASNS	XBP1	ENSSSCP00000016267	ENSSSCP00000048871	Asparagine synthetase [glutamine-hydrolyzing].	BZIP domain-containing protein.	0.437
ATF4	ASNS	ENSSSCP00000057464	ENSSSCP00000016267	Activating transcription factor 4.	Asparagine synthetase [glutamine-hydrolyzing].	0.716
ATF4	BECN1	ENSSSCP00000057464	ENSSSCP00000018420	Activating transcription factor 4.	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	0.458
ATF4	EIF2AK3	ENSSSCP00000057464	ENSSSCP00000029692	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.542
ATF4	HSPA5	ENSSSCP00000057464	ENSSSCP00000055982	Activating transcription factor 4.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.871
ATF4	NFE2L2	ENSSSCP00000057464	ENSSSCP00000064368	Activating transcription factor 4.	Nuclear factor, erythroid 2 like 2.	0.439
ATF4	SESN2	ENSSSCP00000057464	ENSSSCP00000064491	Activating transcription factor 4.	Sestrin 2.	0.483
ATF4	XBP1	ENSSSCP00000057464	ENSSSCP00000048871	Activating transcription factor 4.	BZIP domain-containing protein.	0.926
ATG14	BECN1	ENSSSCP00000005437	ENSSSCP00000018420	Autophagy related 14.	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	0.999
ATG14	PIK3C3	ENSSSCP00000005437	ENSSSCP00000004057	Autophagy related 14.	Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...]	0.999
ATG14	PRKAA2	ENSSSCP00000005437	ENSSSCP00000055569	Autophagy related 14.	5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...]	0.507
ATG14	PRKAG1	ENSSSCP00000005437	ENSSSCP00000000193	Autophagy related 14.	5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...]	0.499
ATG14	PRKAG2	ENSSSCP00000005437	ENSSSCP00000017412	Autophagy related 14.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.499
ATG14	PRKAG3	ENSSSCP00000005437	ENSSSCP00000017163	Autophagy related 14.	5'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...]	0.499
ATG14	SH3GLB1	ENSSSCP00000005437	ENSSSCP00000007389	Autophagy related 14.	SH3 domain containing GRB2 like, endophilin B1.	0.422
BECN1	ATF4	ENSSSCP00000018420	ENSSSCP00000057464	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	Activating transcription factor 4.	0.458
BECN1	ATG14	ENSSSCP00000018420	ENSSSCP00000005437	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	Autophagy related 14.	0.999
BECN1	FOXO3	ENSSSCP00000018420	ENSSSCP00000004735	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	Forkhead box protein O3 isoform X1.	0.460