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RALY RALY LIMA1 LIMA1 APOB APOB MALRD1 MALRD1 SOAT2 SOAT2 TTC39A TTC39A EPHX2 EPHX2 CES1 CES1 CYP7B1 CYP7B1 LOC100624062 LOC100624062 MTTP MTTP SCARB1 SCARB1 SIRT1 SIRT1 PLA2G12B PLA2G12B LRP5 LRP5 EHD1 EHD1 NR1H3 NR1H3 ABCG4 ABCG4 ABCB11 ABCB11 PLSCR3 PLSCR3 LCAT LCAT NUS1 NUS1 TMEM97 TMEM97 LIPG LIPG CAV1 CAV1 CAV3 CAV3 ABCG5 ABCG5 APOA1 APOA1 CYP7A1 CYP7A1 NR1D1 NR1D1 INSIG1 INSIG1 FABP4 FABP4 NPC1L1 NPC1L1 MED13 MED13 SOAT1 SOAT1 SREBF2 SREBF2 PCSK9 PCSK9 MYLIP MYLIP APOE APOE NR1H2 NR1H2 ANGPTL3 ANGPTL3 RORA RORA LIPC LIPC TTC39B TTC39B ABCA1 ABCA1 NPC1 NPC1 LAMTOR1 LAMTOR1 A0A5G2R3N8_PIG A0A5G2R3N8_PIG LDLR LDLR APOA2 APOA2 TSKU TSKU HNF4A HNF4A LDLRAP1 LDLRAP1 GRAMD1B GRAMD1B RALYL RALYL ABCG8 ABCG8 NR1H4 NR1H4 APOC3 APOC3 COMMD9 COMMD9 SLC37A4 SLC37A4 CYP39A1 CYP39A1 APOA4 APOA4 NR5A2 NR5A2 ABCG1 ABCG1 XBP1 XBP1 PLA2G10 PLA2G10 G6PC G6PC NFE2L1 NFE2L1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RALYRALY heterogeneous nuclear ribonucleoprotein. (365 aa)
LIMA1LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholest [...] (766 aa)
APOBApolipoprotein B-100. (4573 aa)
MALRD1Uncharacterized protein. (310 aa)
SOAT2O-acyltransferase. (566 aa)
TTC39ATetratricopeptide repeat protein 39A isoform 1. (581 aa)
EPHX2Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N- terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12- phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (575 aa)
CES1Liver carboxylesterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis [...] (564 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa)
LOC100624062Uncharacterized protein. (585 aa)
MTTPMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
PLA2G12BPhospholipase A2 group XIIB. (194 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (564 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (470 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform a. (646 aa)
ABCB11ATP binding cassette subfamily B member 11. (1375 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (297 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (471 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (177 aa)
LIPGLipase G, endothelial type. (501 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
CAV3Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa)
ABCG5ATP binding cassette subfamily G member 5. (657 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
CYP7A1Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa)
FABP4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
NPC1L1NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2173 aa)
SOAT1O-acyltransferase. (549 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1135 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (458 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (461 aa)
RORARAR related orphan receptor A. (530 aa)
LIPCLipase C, hepatic type. (501 aa)
TTC39BTetratricopeptide repeat domain 39B. (709 aa)
ABCA1Uncharacterized protein. (2261 aa)
NPC1NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
A0A5G2R3N8_PIGUncharacterized protein. (135 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
TSKUTsukushi, small leucine rich proteoglycan. (357 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (505 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (336 aa)
GRAMD1BGRAM domain containing 1B. (878 aa)
RALYLRALY RNA binding protein like. (306 aa)
ABCG8ATP binding cassette subfamily G member 8. (730 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (509 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
COMMD9COMM domain containing 9. (197 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
CYP39A1Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa)
APOA4Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. (392 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
ABCG1ATP binding cassette subfamily G member 1. (679 aa)
XBP1BZIP domain-containing protein. (378 aa)
PLA2G10Phospholipase A(2). (188 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (766 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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