(19 nodes) Nuclear retinoic acid receptor binding network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNOT1	CCR4-NOT transcription complex subunit 1. (2343 aa)
	RARG	Retinoic acid receptor gamma. (554 aa)
	TACC1	TACC_C domain-containing protein. (801 aa)
	PRMT2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (435 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (509 aa)
	NRIP1	Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)
	VDR	Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
	LOC106506226	TACC_C domain-containing protein. (378 aa)
	ARID5A	AT-rich interaction domain 5A. (846 aa)
	LOC100622504	Uncharacterized protein. (469 aa)
	ACTN4	Actinin alpha 4. (1160 aa)
	LRIF1	Ligand-dependent nuclear receptor-interacting factor 1 isoform X1. (762 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (458 aa)
	MED25	Mediator complex subunit 25. (794 aa)
	ASXL1	ASXL transcriptional regulator 1. (1542 aa)
	CTBP2	C-terminal binding protein 2. (982 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (470 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
	SNW1	SNW domain-containing protein 1 isoform 2. (536 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNOT1	MED1	ENSSSCP00000023830	ENSSSCP00000018552	CCR4-NOT transcription complex subunit 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.408
CTBP2	NRIP1	ENSSSCP00000011449	ENSSSCP00000061061	C-terminal binding protein 2.	Nuclear receptor-interacting protein 1 isoform X1.	0.446
CTBP2	SNW1	ENSSSCP00000011449	ENSSSCP00000020257	C-terminal binding protein 2.	SNW domain-containing protein 1 isoform 2.	0.610
MED1	CNOT1	ENSSSCP00000018552	ENSSSCP00000023830	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	CCR4-NOT transcription complex subunit 1.	0.408
MED1	MED25	ENSSSCP00000018552	ENSSSCP00000003469	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 25.	0.982
MED1	NR1H2	ENSSSCP00000018552	ENSSSCP00000003483	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor subfamily 1 group H member 2.	0.754
MED1	NR1H3	ENSSSCP00000018552	ENSSSCP00000014069	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor subfamily 1 group H member 3.	0.754
MED1	NR1H4	ENSSSCP00000018552	ENSSSCP00000063172	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor subfamily 1 group H member 4.	0.785
MED1	RARG	ENSSSCP00000018552	ENSSSCP00000032642	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoic acid receptor gamma.	0.775
MED1	VDR	ENSSSCP00000018552	ENSSSCP00000055650	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity).	0.850
MED25	MED1	ENSSSCP00000003469	ENSSSCP00000018552	Mediator complex subunit 25.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.982
NR1H2	MED1	ENSSSCP00000003483	ENSSSCP00000018552	Nuclear receptor subfamily 1 group H member 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.754
NR1H2	NR1H3	ENSSSCP00000003483	ENSSSCP00000014069	Nuclear receptor subfamily 1 group H member 2.	Nuclear receptor subfamily 1 group H member 3.	0.905
NR1H3	MED1	ENSSSCP00000014069	ENSSSCP00000018552	Nuclear receptor subfamily 1 group H member 3.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.754
NR1H3	NR1H2	ENSSSCP00000014069	ENSSSCP00000003483	Nuclear receptor subfamily 1 group H member 3.	Nuclear receptor subfamily 1 group H member 2.	0.905
NR1H4	MED1	ENSSSCP00000063172	ENSSSCP00000018552	Nuclear receptor subfamily 1 group H member 4.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.785
NRIP1	CTBP2	ENSSSCP00000061061	ENSSSCP00000011449	Nuclear receptor-interacting protein 1 isoform X1.	C-terminal binding protein 2.	0.446
NRIP1	RARG	ENSSSCP00000061061	ENSSSCP00000032642	Nuclear receptor-interacting protein 1 isoform X1.	Retinoic acid receptor gamma.	0.453
RARG	MED1	ENSSSCP00000032642	ENSSSCP00000018552	Retinoic acid receptor gamma.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.775
RARG	NRIP1	ENSSSCP00000032642	ENSSSCP00000061061	Retinoic acid receptor gamma.	Nuclear receptor-interacting protein 1 isoform X1.	0.453