STRINGSTRING
TRIM28 TRIM28 ERCC2 ERCC2 IFNG IFNG IRF4 IRF4 GATA3 GATA3 SKI SKI PINX1 PINX1 A0A287APK2_PIG A0A287APK2_PIG NME1 NME1 HES1 HES1 ACD ACD MMP9 MMP9 PLAUR PLAUR LAMTOR5 LAMTOR5 POU4F1 POU4F1 A0A287BCA6_PIG A0A287BCA6_PIG NIBAN2 NIBAN2 HAND2 HAND2 EDF1 EDF1 DDRGK1 DDRGK1 TXN TXN PRKN PRKN TXNDC2 TXNDC2 SIRT2 SIRT2 MYOCD MYOCD PARK7 PARK7 GTF2B GTF2B RB1 RB1 HMGB2 HMGB2 MMP8 MMP8 NEUROD1 NEUROD1 ISL1 ISL1 EP300 EP300 HIPK2 HIPK2 EGF EGF TRIM6 TRIM6 TGFB1 TGFB1 CTNNB1 CTNNB1 PAX6 PAX6 TRAF6 TRAF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM28Tripartite motif containing 28. (868 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IRF4Interferon regulatory factor 4. (451 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
SKISKI proto-oncogene. (728 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1 isoform 1. (313 aa)
A0A287APK2_PIGUncharacterized protein. (65 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
HES1Uncharacterized protein. (280 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (477 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
PLAURPlasminogen activator, urokinase receptor. (330 aa)
LAMTOR5Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa)
POU4F1POU domain protein. (421 aa)
A0A287BCA6_PIGThioredoxin domain-containing protein. (99 aa)
NIBAN2Niban apoptosis regulator 2. (740 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
EDF1Endothelial differentiation related factor 1. (203 aa)
DDRGK1DDRGK domain-containing protein 1. (312 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (169 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
TXNDC2Thioredoxin domain-containing protein. (813 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
PARK7DJ-1 protein. (189 aa)
GTF2BGeneral transcription factor IIB. (337 aa)
RB1RB transcriptional corepressor 1. (938 aa)
HMGB2High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa)
MMP8Matrix metallopeptidase 8. (468 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
EP300E1A binding protein p300. (2420 aa)
HIPK2Homeodomain interacting protein kinase 2. (1208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
TRIM6Tripartite motif containing 6. (487 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CTNNB1Catenin beta 1. (808 aa)
PAX6Paired box 6. (498 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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