STRINGSTRING
DPP4 DPP4 CDH13 CDH13 VSTM4 VSTM4 PXN PXN ADGRA2 ADGRA2 PLEKHG5 PLEKHG5 ROBO1 ROBO1 NRP1 NRP1 PLXND1 PLXND1 CCBE1 CCBE1 GIPC1 GIPC1 AMOT AMOT FAP FAP S100A2 S100A2 KDR KDR S100Z S100Z LPXN LPXN CLEC14A CLEC14A LGALS12 LGALS12 VHL VHL SCARB1 SCARB1 STARD13 STARD13 ADTRP ADTRP GPLD1 GPLD1 SRF SRF CCN3 CCN3 RAB13 RAB13 EPHB4 EPHB4 SLIT2 SLIT2 FSTL1 FSTL1 GIPC2 GIPC2 CYP1B1 CYP1B1 FGF2 FGF2 VEGFA VEGFA LGALS8 LGALS8 ABL1 ABL1 EGR3 EGR3 LOC100511937 LOC100511937 MMRN2 MMRN2 CORO1B CORO1B CLN3 CLN3 NOS3 NOS3 CDH5 CDH5 SOX18 SOX18 RHOA RHOA A0A287ANG8_PIG A0A287ANG8_PIG NR4A1 NR4A1 LOXL2 LOXL2 CXCL13 CXCL13 GIPC3 GIPC3 EDN2 EDN2 GREM1 GREM1 EMP2 EMP2 EFNB2 EFNB2 PAXIP1 PAXIP1 PTP4A3 PTP4A3 PRKX PRKX APOA1 APOA1 TGFBR1 TGFBR1 ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DPP4Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa)
CDH13Uncharacterized protein. (771 aa)
VSTM4V-set and transmembrane domain containing 4. (382 aa)
PXNUncharacterized protein. (1072 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1336 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
ROBO1Roundabout guidance receptor 1. (1687 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
PLXND1Plexin D1. (1926 aa)
CCBE1Collagen and calcium binding EGF domains 1. (407 aa)
GIPC1GIPC PDZ domain containing family member 1. (405 aa)
AMOTAngiomotin isoform X1. (1088 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
S100A2S100 calcium binding protein A2. (170 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
CLEC14AC-type lectin domain family 14 member A. (493 aa)
LGALS12Galectin. (330 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (205 aa)
SCARB1Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa)
STARD13Uncharacterized protein. (541 aa)
ADTRPAndrogen dependent TFPI regulating protein. (230 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (906 aa)
SRFSerum response factor. (512 aa)
CCN3Cellular communication network factor 3. (398 aa)
RAB13Uncharacterized protein. (203 aa)
EPHB4EPH receptor B4. (935 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
FSTL1Follistatin like 1. (307 aa)
GIPC2PDZ domain-containing protein GIPC2 isoform 1. (313 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa)
LGALS8Galectin. (368 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
LOC100511937Uncharacterized protein. (532 aa)
MMRN2Multimerin 2. (931 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (496 aa)
CLN3Battenin. (414 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa)
SOX18SRY-box transcription factor 18. (389 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
A0A287ANG8_PIGProtein kinase domain-containing protein. (183 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
CXCL13C-X-C motif chemokine. (111 aa)
GIPC3GIPC PDZ domain containing family member 3. (314 aa)
EDN2Endothelin 2. (180 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
EFNB2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (335 aa)
PAXIP1PAX interacting protein 1. (1030 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (173 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (358 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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