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PCK1 PCK1 GGT1 GGT1 HAAO HAAO LOC110256626 LOC110256626 ME2 ME2 A0A286ZS45_PIG A0A286ZS45_PIG SHMT1 SHMT1 ACSF3 ACSF3 IDH2 IDH2 ALDH1L1 ALDH1L1 ASS1 ASS1 GCLM GCLM A0A287ACB9_PIG A0A287ACB9_PIG SHMT2 SHMT2 IDH1 IDH1 FTCD FTCD QPRT QPRT NAGS NAGS ALDH4A1 ALDH4A1 ACOT8 ACOT8 ACLY ACLY OGDH OGDH KYNU KYNU ALDH1L2 ALDH1L2 GLS2 GLS2 D2HGDH D2HGDH ME3 ME3 NIT2 NIT2 GAD2 GAD2 GOT1 GOT1 HOGA1 HOGA1 ALDH18A1 ALDH18A1 ASL ASL KYAT3 KYAT3 FPGS FPGS TAT TAT ME1 ME1 MDH2 MDH2 MRPS36 MRPS36 KMO KMO C10orf62 C10orf62 MTHFD1 MTHFD1 GCLC GCLC ALDH5A1 ALDH5A1 HAL HAL GAD1 GAD1 AMDHD1 AMDHD1 LOC100522040 LOC100522040 GOT1L1 GOT1L1 DDO DDO FH FH MTHFD1L MTHFD1L PRODH2 PRODH2 MTRR MTRR OAT OAT ADHFE1 ADHFE1 DLST DLST GLS GLS UROC1 UROC1 MDH1B MDH1B GPT2 GPT2 GOT2 GOT2 MDH1 MDH1 SDHA SDHA SDHAF3 SDHAF3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
GGT1Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] (617 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
LOC110256626Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa)
ME2Malic enzyme. (678 aa)
A0A286ZS45_PIGUncharacterized protein. (116 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa)
ACSF3Acyl-CoA synthetase family member 3. (712 aa)
IDH2Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. (452 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (867 aa)
ASS1Argininosuccinate synthase 1. (428 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (274 aa)
A0A287ACB9_PIGUncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (340 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (463 aa)
FTCDFormimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. (533 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
NAGSN-acetyltransferase domain-containing protein. (381 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (605 aa)
ACOT8Acyl-coenzyme A thioesterase 8. (317 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa)
OGDHOxoglutarate dehydrogenase. (1035 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa)
ALDH1L2Aldehyde dehydrogenase 1 family member L2; Belongs to the aldehyde dehydrogenase family. (739 aa)
GLS2Glutaminase 2. (602 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (578 aa)
ME3Malic enzyme. (604 aa)
NIT2Nitrilase family member 2. (283 aa)
GAD2Glutamate decarboxylase 2; Catalyzes the production of GABA. (584 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
HOGA1Uncharacterized protein; Belongs to the DapA family. (327 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
ASLArgininosuccinate lyase isoform 1. (464 aa)
KYAT3Kynurenine aminotransferase 3. (471 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
ME1NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)
MDH2Malate dehydrogenase, mitochondrial. (395 aa)
MRPS36Mitochondrial ribosomal protein S36. (149 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (547 aa)
C10orf62Chromosome 10 open reading frame 62. (233 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
GCLCGlutamate--cysteine ligase catalytic subunit isoform X3. (588 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
HALHistidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (728 aa)
AMDHD1Amidohydrolase domain containing 1. (389 aa)
LOC100522040Formiminotransferase N-terminal subdomain-containing protein isoform 1. (328 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (404 aa)
DDOD-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Belongs to the DAMOX/DASOX family. (369 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
PRODH2Uncharacterized protein. (1017 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (737 aa)
OATUncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa)
ADHFE1Fe-ADH domain-containing protein. (489 aa)
DLST2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl [...] (446 aa)
GLSGlutaminase. (669 aa)
UROC1Urocanate hydratase 1. (698 aa)
MDH1BMalate dehydrogenase 1B. (523 aa)
GPT2Glutamic--pyruvic transaminase 2. (547 aa)
GOT2Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa)
MDH1Malate dehydrogenase, cytoplasmic. (352 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (664 aa)
SDHAF3Succinate dehydrogenase assembly factor 3, mitochondrial. (125 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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