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| | ABHD12 | Monoacylglycerol lipase ABHD12 isoform a. (396 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase type 2 isoform X2. (245 aa) |
| | LYPLA2 | Acyl-protein thioesterase 2 isoform X3. (281 aa) |
| | CRABP1 | Cellular retinoic acid-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa) |
| | GDPD3 | Glycerophosphodiester phosphodiesterase domain containing 3. (305 aa) |
| | FUCA1 | Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (467 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa) |
| | PNPLA3 | Patatin like phospholipase domain containing 3. (441 aa) |
| | CEL | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (585 aa) |
| | LIPG | Lipase G, endothelial type. (501 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (370 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (841 aa) |
| | AOAH | Acyloxyacyl hydrolase. (575 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa) |
| | LIPI | Lipase I. (480 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3. (1006 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa) |
| | LPIN2 | Lipin 2. (937 aa) |
| | NEU3 | Neuraminidase 3. (428 aa) |
| | PEX13 | Peroxisomal biogenesis factor 13. (403 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha. (369 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | ABHD16B | Abhydrolase domain containing 16B. (470 aa) |
| | MGLL | Monoglyceride lipase. (456 aa) |
| | PLA2G6 | Phospholipase A2 group VI. (806 aa) |
| | PLA2G5 | Phospholipase A(2). (138 aa) |
| | PHYH | Phytanoyl-CoA 2-hydroxylase. (334 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (417 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (745 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa) |
| | ABHD6 | Abhydrolase domain containing 6. (337 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (453 aa) |
| | HEXA | Beta-hexosaminidase. (545 aa) |
| | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] (612 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa) |
| | PEX5 | Peroxisomal biogenesis factor 5. (660 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (732 aa) |
| | ECH1 | Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (368 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa) |
| | APOB | Apolipoprotein B-100. (4573 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa) |
| | TMEM130 | Transmembrane protein 130. (342 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa) |
| | HACL1 | 2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (600 aa) |
| | NEU4 | Neuraminidase 4. (471 aa) |
| | PEX7 | Peroxisomal biogenesis factor 7. (308 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (659 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa) |
| | LOC102164418 | Amidase domain-containing protein. (375 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | ACAT2 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (447 aa) |
| | NAGA | Alpha-galactosidase. (406 aa) |
| | PLA2G10 | Phospholipase A(2). (188 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (656 aa) |
| | ACER3 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (324 aa) |
| | LOC100739561 | Glycerophosphodiester phosphodiesterase domain-containing protein 1. (314 aa) |
| | FAAH | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. (579 aa) |
| | NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D. (426 aa) |
| | PNLIPRP2 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (574 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1425 aa) |
| | PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domai [...] (730 aa) |
| | ABCD4 | ATP binding cassette subfamily D member 4. (604 aa) |
| | GLA | Alpha-galactosidase. (433 aa) |
| | GPCPD1 | Glycerophosphocholine phosphodiesterase GPCPD1. (672 aa) |
| | CROT | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (612 aa) |
| | PLA2G4E | Phospholipase A2. (872 aa) |
| | HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (314 aa) |
| | PRDX6 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) |
| | BCO1 | Beta-carotene oxygenase 1. (547 aa) |
| | LIPE | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (609 aa) |
| | SMPD4 | Sphingomyelin phosphodiesterase 4 isoform 2. (868 aa) |
| | PLA2G7 | Platelet-activating factor acetylhydrolase. (441 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | BCO2 | Beta-carotene oxygenase 2. (544 aa) |
| | NUDT8 | Nudix hydrolase domain-containing protein. (140 aa) |
| | SMPDL3B | Sphingomyelin phosphodiesterase acid like 3B. (406 aa) |
| | PNPLA4-2 | Patatin like phospholipase domain containing 4. (256 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. (438 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (486 aa) |
| | PLA2G4A | Phospholipase A2. (758 aa) |
| | DECR2 | Peroxisomal 2,4-dienoyl-CoA reductase. (320 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2. (146 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | AIG1 | Androgen induced 1. (315 aa) |
| | ASAH2 | Neutral ceramidase. (786 aa) |
| | PEX2 | Peroxisomal biogenesis factor 2. (320 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | APOC3 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa) |
| | ABHD16A | Abhydrolase domain containing 16A. (579 aa) |
| | PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain [...] (558 aa) |
| | ECHDC2 | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (335 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa) |
| | PNPLA7 | Patatin like phospholipase domain containing 7. (1413 aa) |
| | NUDT7 | Nudix hydrolase 7. (237 aa) |
| | ZPBP2 | Zona pellucida binding protein 2. (363 aa) |
| | A0A5G2QSB6_PIG | Uncharacterized protein. (146 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (673 aa) |
| | GDPD1 | GP-PDE domain-containing protein. (322 aa) |
| | LPIN1 | Lipin 1. (957 aa) |
| | ACADVL | Acyl-CoA dehydrogenase very long chain. (681 aa) |
| | GM2A | Ganglioside GM2 activator isoform X1. (193 aa) |
| | DECR1 | Uncharacterized protein. (348 aa) |
| | NUDT19 | Nudix hydrolase 19. (322 aa) |
| | APOA2 | Apolipoprotein A-II preproprotein. (100 aa) |
| | CPT2 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa) |
| | A0A5G2R3N8_PIG | Uncharacterized protein. (135 aa) |
| | GBA3 | Glucosylceramidase beta 3 (gene/pseudogene); Belongs to the glycosyl hydrolase 1 family. (469 aa) |
| | SLC25A17 | Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (329 aa) |
| | ABCD2 | ATP-binding cassette sub-family D member 2 isoform X1. (741 aa) |
| | ALDH1L2 | Aldehyde dehydrogenase 1 family member L2; Belongs to the aldehyde dehydrogenase family. (739 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (230 aa) |
| | NEU1 | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). (432 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | PNPLA1 | Patatin like phospholipase domain containing 1. (501 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | ETFB | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. (255 aa) |
| | ANGPTL3 | Fibrinogen C-terminal domain-containing protein. (461 aa) |
| | ECHDC1 | Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa) |
| | SMPDL3A | Acid sphingomyelinase-like phosphodiesterase. (452 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) |
| | LIPC | Lipase C, hepatic type. (501 aa) |
| | SLC27A2 | Solute carrier family 27 (Fatty acid transporter) member 2. (620 aa) |
| | PLA2G4F | Phospholipase A2. (852 aa) |
| | PLA2G4D | Phospholipase A2. (812 aa) |
| | JMJD7 | Phospholipase A2. (780 aa) |
| | PLPP6 | Phospholipid phosphatase 6. (300 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (915 aa) |
| | SMPD5 | Endo/exonuclease/phosphatase domain-containing protein. (486 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1379 aa) |
| | LPIN3 | LNS2 domain-containing protein. (826 aa) |
| | CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | ABHD1 | Abhydrolase domain containing 1. (405 aa) |
| | HADHB | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa) |
| | HADHA | Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa) |
| | AUH | Methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa) |
| | ACAD10 | Acyl-CoA dehydrogenase family member 10. (1036 aa) |
| | PLBD2 | Phospholipase B-like; Putative phospholipase. (588 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa) |
| | INPP5F | Phosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa) |
| | ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) |
| | ACAD11 | Acyl-CoA dehydrogenase family member 11. (780 aa) |
| | LIPH | Lipase H. (451 aa) |
| | PNPLA4 | PNPLA domain-containing protein. (320 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (732 aa) |
| | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | DAGLA | Diacylglycerol lipase alpha. (1058 aa) |
| | HEXB | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (538 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa) |
| | PNPLA8 | Calcium-independent phospholipase A2-gamma isoform 1. (783 aa) |
| | DDHD2 | Phospholipase DDHD2 isoform 1. (715 aa) |
| | ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa) |
| | NEU2 | Neuraminidase 2. (379 aa) |
| | PLPP1 | Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa) |
| | ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase 7. (473 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | LOC100525350 | S5A_REDUCTASE domain-containing protein. (318 aa) |
| | ACOT8 | Acyl-coenzyme A thioesterase 8. (317 aa) |
| | GALC | Galactocerebrosidase isoform a. (685 aa) |
| | PODN | LRRNT domain-containing protein. (697 aa) |
| | HSD17B4 | Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa) |
| | ABHD12B | Abhydrolase domain containing 12B. (441 aa) |
