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| | HSD17B4 | Peroxisomal multifunctional enzyme type 2 isoform 2. (737 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase type 2 isoform X2. (245 aa) |
| | HSD17B6 | Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | CRABP1 | Cellular retinoic acid-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa) |
| | HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase. (373 aa) |
| | AMT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa) |
| | GALM | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). (350 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (673 aa) |
| | OCRL | OCRL inositol polyphosphate-5-phosphatase. (903 aa) |
| | AICDA | Activation induced cytidine deaminase. (224 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (547 aa) |
| | LPIN1 | Lipin 1. (957 aa) |
| | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (562 aa) |
| | GNPDA2 | Glucosamine-6-phosphate isomerase. (354 aa) |
| | ACADVL | Acyl-CoA dehydrogenase very long chain. (681 aa) |
| | BCKDHB | Branched chain keto acid dehydrogenase E1 subunit beta. (396 aa) |
| | DECR1 | Uncharacterized protein. (348 aa) |
| | INPP5J | Inositol polyphosphate-5-phosphatase J. (1066 aa) |
| | NUDT19 | Nudix hydrolase 19. (322 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | CPT2 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa) |
| | INPP5E | Inositol polyphosphate-5-phosphatase E. (829 aa) |
| | ALDOB | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (366 aa) |
| | HK1 | Uncharacterized protein. (919 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (446 aa) |
| | GCAT | Glycine C-acetyltransferase. (467 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (486 aa) |
| | OTC | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (354 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (521 aa) |
| | GSTZ1 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (247 aa) |
| | IVD | Uncharacterized protein. (568 aa) |
| | FOXK1 | Forkhead box K1. (762 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa) |
| | QPRT | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa) |
| | IDO2 | Indoleamine 2,3-dioxygenase 2. (412 aa) |
| | INPP5K | Inositol polyphosphate-5-phosphatase K. (480 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (605 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (344 aa) |
| | IMPA1 | Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates. (363 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (370 aa) |
| | TDH | L-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. (373 aa) |
| | ARG1 | Arginase-1. (337 aa) |
| | PSORS1C2 | Psoriasis susceptibility 1 candidate 2. (135 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (841 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa) |
| | BCKDHA | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (562 aa) |
| | PFKM | ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (810 aa) |
| | NQO2 | N-ribosyldihydronicotinamide:quinone reductase 2. (239 aa) |
| | A0A286ZJJ9_PIG | Uncharacterized protein. (313 aa) |
| | LOC110255953 | Beta_elim_lyase domain-containing protein. (392 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa) |
| | LOC110256626 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa) |
| | DDAH2 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1. (285 aa) |
| | LPIN2 | Lipin 2. (937 aa) |
| | CYP7A1 | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa) |
| | PNKD | PNKD metallo-beta-lactamase domain containing. (432 aa) |
| | PEX13 | Peroxisomal biogenesis factor 13. (403 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha. (369 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | GPD2 | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (779 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa) |
| | AGXT2 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa) |
| | ABAT | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (520 aa) |
| | SULT1E1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa) |
| | LOC100525099 | Amine oxidase. (562 aa) |
| | SYNJ1 | Synaptojanin 1. (1576 aa) |
| | ACSF3 | Acyl-CoA synthetase family member 3. (712 aa) |
| | ALDH1L1 | 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (867 aa) |
| | PHYH | Phytanoyl-CoA 2-hydroxylase. (334 aa) |
| | AMDHD2 | Amidohydro-rel domain-containing protein. (569 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (410 aa) |
| | DAO | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. (371 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (417 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (745 aa) |
| | IDNK | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (193 aa) |
| | PON3 | Paraoxonase 3. (354 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (453 aa) |
| | RBKS | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (323 aa) |
| | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] (612 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa) |
| | QDPR | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (236 aa) |
| | IMPAD1 | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa) |
| | GK5 | Glycerol kinase 5; Belongs to the FGGY kinase family. (533 aa) |
| | A0A287ABJ1_PIG | Uncharacterized protein. (163 aa) |
| | A0A287ACB9_PIG | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (340 aa) |
| | GAD1 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (728 aa) |
| | PEX5 | Peroxisomal biogenesis factor 5. (660 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (732 aa) |
| | SULT1B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa) |
| | ALDH16A1 | Aldehyde dehydrogenase 16 family member A1. (852 aa) |
| | ECH1 | Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (368 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (389 aa) |
| | LOC100522040 | Formiminotransferase N-terminal subdomain-containing protein isoform 1. (328 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa) |
| | PFKL | 6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (782 aa) |
| | NPL | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway; Belongs to the DapA family. NanA subfamily. (339 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa) |
| | GNPDA1 | Glucosamine-6-phosphate isomerase. (309 aa) |
| | HPD | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (421 aa) |
| | DDO | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Belongs to the DAMOX/DASOX family. (369 aa) |
| | SLC25A17 | Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (329 aa) |
| | APOBEC3B | Uncharacterized protein. (418 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | DERA | Deoxyribose-phosphate aldolase isoform X1. (318 aa) |
| | APOBEC1 | Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa) |
| | TPI1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (285 aa) |
| | ABCD2 | ATP-binding cassette sub-family D member 2 isoform X1. (741 aa) |
| | ALDH1L2 | Aldehyde dehydrogenase 1 family member L2; Belongs to the aldehyde dehydrogenase family. (739 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (230 aa) |
| | ALDH5A1 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (425 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | ARG2 | Arginase. (354 aa) |
| | ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase acylating, mitochondrial isoform 1. (534 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | LDHD | Putative D-lactate dehydrogenase, mitochondrial isoform 2. (484 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa) |
| | ENPP4 | Ectonucleotide pyrophosphatase/phosphodiesterase 4. (453 aa) |
| | HACL1 | 2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (600 aa) |
| | PEX7 | Peroxisomal biogenesis factor 7. (308 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (659 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa) |
| | NUDT1 | Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (277 aa) |
| | LOC102164418 | Amidase domain-containing protein. (375 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | SORD | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). (356 aa) |
| | ENO1 | Alpha-enolase isoform X1. (434 aa) |
| | ACAT2 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (447 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (401 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (321 aa) |
| | PON1 | Paraoxonase 1. (355 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa) |
| | PDXP | Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa) |
| | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (392 aa) |
| | DDAH1 | Dimethylarginine dimethylaminohydrolase 1. (324 aa) |
| | ACADSB | Acyl-CoA dehydrogenase short/branched chain. (432 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | FAAH | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. (579 aa) |
| | ESD | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa) |
| | SARDH | Sarcosine dehydrogenase, mitochondrial. (918 aa) |
| | PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domai [...] (730 aa) |
| | PRODH2 | Uncharacterized protein. (1017 aa) |
| | ABCD4 | ATP binding cassette subfamily D member 4. (604 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (737 aa) |
| | APOBEC2 | Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (224 aa) |
| | NAGK | N-acetylglucosamine kinase. (402 aa) |
| | CROT | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (612 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (555 aa) |
| | GCSH | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (961 aa) |
| | HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (314 aa) |
| | OAT | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa) |
| | A0A287BD08_PIG | Uncharacterized protein; Belongs to the FGGY kinase family. (526 aa) |
| | ADA2 | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). (509 aa) |
| | GLS | Glutaminase. (669 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa) |
| | NUDT8 | Nudix hydrolase domain-containing protein. (140 aa) |
| | GALE | UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (358 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | BCAT2 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). (481 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | IL4I1 | Amine oxidase. (578 aa) |
| | ETFB | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. (255 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | AADACL4 | Arylacetamide deacetylase like 4. (407 aa) |
| | AADACL3 | Arylacetamide deacetylase like 3. (409 aa) |
| | PADI3 | Peptidyl arginine deiminase 3. (664 aa) |
| | INPP5B | Inositol polyphosphate-5-phosphatase B. (877 aa) |
| | ECHDC1 | Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa) |
| | ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) |
| | SLC27A2 | Solute carrier family 27 (Fatty acid transporter) member 2. (620 aa) |
| | HDC | Histidine decarboxylase. (662 aa) |
| | ADAL | Adenosine deaminase-like protein isoform X1. (355 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1027 aa) |
| | ALDH1B1 | Aldehyde dehydrogenase 1 family member B1; Belongs to the aldehyde dehydrogenase family. (517 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (973 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (471 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. (438 aa) |
| | AKR1A1 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detox [...] (365 aa) |
| | GPT | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). (555 aa) |
| | CYP39A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (605 aa) |
| | UROC1 | Urocanate hydratase 1. (698 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1195 aa) |
| | DECR2 | Peroxisomal 2,4-dienoyl-CoA reductase. (320 aa) |
| | NUDT5 | Nudix hydrolase 5; Belongs to the Nudix hydrolase family. (270 aa) |
| | A0A5G2Q7V0_PIG | Uncharacterized protein. (123 aa) |
| | ADH1C | PKS_ER domain-containing protein. (388 aa) |
| | AIG1 | Androgen induced 1. (315 aa) |
| | PAH | Phenylalanine hydroxylase. (450 aa) |
| | UOX | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (374 aa) |
| | PEX2 | Peroxisomal biogenesis factor 2. (320 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (547 aa) |
| | GALK1 | Galactokinase 1. (414 aa) |
| | IDO1 | Uncharacterized protein. (429 aa) |
| | LPIN3 | LNS2 domain-containing protein. (826 aa) |
| | CYP24A1 | 25-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa) |
| | CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | HAGHL | Hydroxyacylglutathione hydrolase like. (316 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1336 aa) |
| | ABHD1 | Abhydrolase domain containing 1. (405 aa) |
| | HADHB | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa) |
| | HADHA | Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa) |
| | ADH4 | Alcohol dehydrogenase 4 isoform 2. (380 aa) |
| | URAD | OHCU_decarbox domain-containing protein. (211 aa) |
| | AUH | Methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa) |
| | ACAD10 | Acyl-CoA dehydrogenase family member 10. (1036 aa) |
| | SDSL | Serine dehydratase like. (353 aa) |
| | ALDH2 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. (537 aa) |
| | UPB1 | Beta-ureidopropionase 1. (393 aa) |
| | MAT1A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (407 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa) |
| | HOGA1 | Uncharacterized protein; Belongs to the DapA family. (327 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa) |
| | INPP5A | Inositol polyphosphate-5-phosphatase A. (472 aa) |
| | SLC25A44 | Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa) |
| | MIOX-2 | Inositol oxygenase. (293 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | BCKDK | Protein-serine/threonine kinase. (453 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (729 aa) |
| | FAH | Fumarylacetoacetase. (480 aa) |
| | PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain [...] (558 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain containing 1. (524 aa) |
| | ECHDC2 | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (335 aa) |
| | SDS | Serine dehydratase. (402 aa) |
| | DLST | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl [...] (446 aa) |
| | MIOX | Inositol oxygenase. (320 aa) |
| | NUDT7 | Nudix hydrolase 7. (237 aa) |
| | ADHFE1 | Fe-ADH domain-containing protein. (489 aa) |
| | HAGH | Lactamase_B domain-containing protein. (609 aa) |
| | PGD | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (319 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (453 aa) |
| | A0A5G2QSB6_PIG | Uncharacterized protein. (146 aa) |
| | C10orf62 | Chromosome 10 open reading frame 62. (233 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase. (377 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | BPNT1 | 3'(2'), 5'-bisphosphate nucleotidase 1. (354 aa) |
| | IL11RA | Uncharacterized protein. (422 aa) |
| | GALT | Galactose-1-phosphate uridylyltransferase. (331 aa) |
| | GAD2 | Glutamate decarboxylase 2; Catalyzes the production of GABA. (584 aa) |
| | THNSL1 | Threonine synthase like 1. (768 aa) |
| | PFKP | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (835 aa) |
| | ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) |
| | ACAD11 | Acyl-CoA dehydrogenase family member 11. (780 aa) |
| | GK | Uncharacterized protein; Belongs to the FGGY kinase family. (590 aa) |
| | PGK1 | Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (732 aa) |
| | RENBP | N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway; Belongs to the N-acylglucosamine 2-epimerase family. (450 aa) |
| | GATD1 | Glutamine amidotransferase-like class 1 domain-containing protein 1 isoform 1. (220 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | TKFC | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (By similarity). Belongs to the dihydroxyacetone kinase (DAK) family. (508 aa) |
| | CDO1 | Cysteine dioxygenase. (200 aa) |
| | MGAT1 | Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. (447 aa) |
| | MTMR2 | Myotubularin-related protein 2 isoform 1. (643 aa) |
| | PON2 | Serum paraoxonase/arylesterase 2 isoform 1. (354 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa) |
| | INPP1 | Inositol polyphosphate 1-phosphatase isoform X1. (402 aa) |
| | ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa) |
| | SCLY | Selenocysteine lyase. (451 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (402 aa) |
| | AKR1D1 | 3-oxo-5-beta-steroid 4-dehydrogenase isoform 1. (326 aa) |
| | FOXK2 | Forkhead box protein K2. (656 aa) |
| | BLMH | Bleomycin hydrolase; Belongs to the peptidase C1 family. (454 aa) |
| | THNSL2 | Threonine synthase like 2. (482 aa) |
| | LOC100525350 | S5A_REDUCTASE domain-containing protein. (318 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa) |
| | SYNJ2 | Synaptojanin 2. (1402 aa) |
| | ACOT8 | Acyl-coenzyme A thioesterase 8. (317 aa) |
| | CYP27A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (581 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | ENOSF1 | Mitochondrial enolase superfamily member 1 isoform rTSbeta. (443 aa) |
| | FTCD | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. (533 aa) |
| | PODN | LRRNT domain-containing protein. (697 aa) |
