STRINGSTRING
CADPS2 CADPS2 UNC13A UNC13A CPLX2 CPLX2 STX4 STX4 BCR BCR SNAP23 SNAP23 STX3 STX3 SYT3 SYT3 NKG7 NKG7 STX11 STX11 RASGRP1 RASGRP1 CPLX4 CPLX4 F1SP87_PIG F1SP87_PIG LYN LYN TMEM79 TMEM79 SV2A SV2A STXBP3 STXBP3 STX1A STX1A DMTN DMTN P2RX7 P2RX7 PLA2G3 PLA2G3 SNAP29 SNAP29 ZP4 ZP4 CTBP2 CTBP2 SYT2 SYT2 NLGN1 NLGN1 RAB11B RAB11B RAB3A RAB3A CRHBP CRHBP SYT9 SYT9 RAPGEF4 RAPGEF4 UNC13D UNC13D ADORA2B ADORA2B SYT8 SYT8 CLNK CLNK STX1B STX1B SYT12 SYT12 SYT5 SYT5 STX2 STX2 PPP3CB PPP3CB BLK BLK PPFIA3 PPFIA3 SYK SYK SNAPIN SNAPIN CORO1A CORO1A TMED10 TMED10 BRAF BRAF STXBP1 STXBP1 SYT4 SYT4 SYT6 SYT6 RAB27A RAB27A VAMP7 VAMP7 SYT10 SYT10 SYT1 SYT1 LRRC1 LRRC1 RAB44 RAB44 CPLX3 CPLX3 PSEN1 PSEN1 SYNGR4 SYNGR4 NLRP5 NLRP5 CHGA CHGA RIMS2 RIMS2 VAMP2 VAMP2 VAMP3 VAMP3 CADPS CADPS UNC13B UNC13B RAB11FIP5 RAB11FIP5 PLEK PLEK SYNGR3 SYNGR3 KIT KIT PTGDS PTGDS RABGEF1 RABGEF1 LOC100625711 LOC100625711 RAB31 RAB31 SYNGR2 SYNGR2 RIMS1 RIMS1 P2RX1 P2RX1 OTOF OTOF ABCA12 ABCA12 RAB11FIP2 RAB11FIP2 MILR1 MILR1 UNC13C UNC13C DOC2B DOC2B PRRT2 PRRT2 SNAP47 SNAP47 S100A13 S100A13 ERC2 ERC2 SNAP25 SNAP25 RAP1A RAP1A RAB26 RAB26 SYT17 SYT17 RIMS3 RIMS3 SYT11 SYT11 NOTCH1 NOTCH1 A0A287AZ68_PIG A0A287AZ68_PIG SYT7 SYT7 RAB11FIP1 RAB11FIP1 STEAP3 STEAP3 SYT13 SYT13 GRP GRP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CADPS2Calcium dependent secretion activator 2. (1297 aa)
UNC13AUncharacterized protein. (1581 aa)
CPLX2Complexin 2. (163 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (338 aa)
BCRBCR activator of RhoGEF and GTPase. (1274 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (347 aa)
SYT3Synaptotagmin-3 isoform X1. (591 aa)
NKG7Uncharacterized protein. (165 aa)
STX11Syntaxin-11 isoform X1; Belongs to the syntaxin family. (287 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
CPLX4Complexin 4. (160 aa)
F1SP87_PIGUncharacterized protein. (141 aa)
LYNTyrosine-protein kinase. (512 aa)
TMEM79Transmembrane protein 79. (395 aa)
SV2ASynaptic vesicle glycoprotein 2A isoform 1. (742 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (295 aa)
DMTNDematin actin binding protein. (405 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PLA2G3Phospholipase A2 group III. (501 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
ZP4Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. (536 aa)
CTBP2C-terminal binding protein 2. (982 aa)
SYT2Synaptotagmin 2. (417 aa)
NLGN1Neuroligin 1. (823 aa)
RAB11BUncharacterized protein. (205 aa)
RAB3ARas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
SYT9Synaptotagmin-9. (491 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (995 aa)
UNC13DUnc-13 homolog D. (1090 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
SYT8Synaptotagmin 8. (381 aa)
CLNKCytokine dependent hematopoietic cell linker. (446 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
SYT12Synaptotagmin-12 isoform X3. (421 aa)
SYT5Synaptotagmin 5. (385 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (347 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
BLKTyrosine-protein kinase. (501 aa)
PPFIA3PTPRF interacting protein alpha 3. (1235 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
TMED10Transmembrane emp24 domain-containing protein 10. (219 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
SYT4Synaptotagmin 4. (425 aa)
SYT6Synaptotagmin 6. (532 aa)
RAB27ARas-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. (221 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa)
SYT10Synaptotagmin-10. (523 aa)
SYT1Synaptotagmin 1. (379 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
RAB44RAB44, member RAS oncogene family. (984 aa)
CPLX3Complexin 3. (158 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
SYNGR4Synaptogyrin. (234 aa)
NLRP5Uncharacterized protein. (1048 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Belongs to the chromogranin/secretogranin protein family. (596 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1348 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (189 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (217 aa)
CADPSUncharacterized protein. (1370 aa)
UNC13BUncharacterized protein. (4266 aa)
RAB11FIP5Uncharacterized protein. (1391 aa)
PLEKPleckstrin. (408 aa)
SYNGR3Synaptogyrin. (253 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (297 aa)
RABGEF1Uncharacterized protein. (503 aa)
LOC100625711Uncharacterized protein. (511 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
SYNGR2Synaptogyrin. (226 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1684 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (458 aa)
OTOFOtoferlin. (1997 aa)
ABCA12ATP binding cassette subfamily A member 12. (2593 aa)
RAB11FIP2Rab11 family-interacting protein 2 isoform 1. (512 aa)
MILR1Mast cell immunoglobulin like receptor 1. (340 aa)
UNC13CUnc-13 homolog C. (2214 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 3. (406 aa)
SNAP47Synaptosome associated protein 47. (449 aa)
S100A13S_100 domain-containing protein; Belongs to the S-100 family. (209 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (969 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAB26RAB26, member RAS oncogene family. (249 aa)
SYT17Synaptotagmin 17. (505 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (312 aa)
SYT11Synaptotagmin 11. (438 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
A0A287AZ68_PIGPDZ domain-containing protein. (909 aa)
SYT7Synaptotagmin-7 isoform X2. (686 aa)
RAB11FIP1Uncharacterized protein. (642 aa)
STEAP3STEAP3 metalloreductase. (526 aa)
SYT13Synaptotagmin-13 isoform 1. (426 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (146 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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