STRINGSTRING
LY49 LY49 LOC106507518 LOC106507518 LOC100523789 LOC100523789 LAG3 LAG3 PLCG2 PLCG2 TYROBP TYROBP TRIM62 TRIM62 RASGRP1 RASGRP1 PRKDC PRKDC SLAMF6 SLAMF6 POLR3C POLR3C POLR3F POLR3F MAVS MAVS ZBP1 ZBP1 TXK TXK LAMP1 LAMP1 POLR3D POLR3D HMGB2 HMGB2 TLR9 TLR9 USP27X USP27X SH2D1A SH2D1A MATR3 MATR3 STING1 STING1 HPX HPX STAT5B STAT5B MED1 MED1 LBP LBP FCN2 FCN2 ZNFX1 ZNFX1 LOC100519314 LOC100519314 IKBKE IKBKE COCH COCH SLC15A4 SLC15A4 CLNK CLNK IFI35 IFI35 POLR3B POLR3B NMI NMI CGAS CGAS HAVCR2 HAVCR2 TRIM6 TRIM6 IRF3 IRF3 ADAM8 ADAM8 FADD FADD SH2D1B SH2D1B PSPC1 PSPC1 FFAR2 FFAR2 SYK SYK LOC102165642 LOC102165642 VAV1 VAV1 A0A286ZSP8_PIG A0A286ZSP8_PIG KLRK1 KLRK1 A0A286ZWW0_PIG A0A286ZWW0_PIG PLA2G5 PLA2G5 CRTAM CRTAM WNT5A WNT5A CARD9 CARD9 SFPQ SFPQ SIN3A SIN3A CD226 CD226 IL21 IL21 MNDA MNDA IL12B IL12B HSP90AA1 HSP90AA1 TBK1 TBK1 UBE2K UBE2K TIRAP TIRAP PQBP1 PQBP1 PYCARD PYCARD RIOK3 RIOK3 RBM14 RBM14 PARP9 PARP9 NCR3 NCR3 TRIM56 TRIM56 NOD2 NOD2 A0A287BRG1_PIG A0A287BRG1_PIG AKIRIN2 AKIRIN2 NECTIN2 NECTIN2 XRCC5 XRCC5 TOMM70 TOMM70 LSM14A LSM14A EREG EREG CASP6 CASP6 AP1G1 AP1G1 CXorf21 CXorf21 XRCC6 XRCC6 HEXIM1 HEXIM1 CADM1 CADM1 KLRD1 KLRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LY49C-type lectin domain-containing protein. (261 aa)
LOC106507518C-type lectin domain-containing protein. (228 aa)
LOC100523789C-type lectin domain-containing protein. (230 aa)
LAG3Uncharacterized protein. (507 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa)
TRIM62E3 ubiquitin-protein ligase TRIM62 isoform 1. (475 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa)
SLAMF6SLAM family member 6. (321 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
ZBP1Uncharacterized protein. (438 aa)
TXKTyrosine-protein kinase. (551 aa)
LAMP1Uncharacterized protein. (413 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
HMGB2High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa)
MATR3Uncharacterized protein. (897 aa)
STING1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
LBPUncharacterized protein. (586 aa)
FCN2Ficolin-2. (429 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1926 aa)
LOC100519314C-type lectin domain-containing protein. (247 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa)
COCHCochlin isoform X2. (551 aa)
SLC15A4Solute carrier family 15 member 4. (566 aa)
CLNKCytokine dependent hematopoietic cell linker. (446 aa)
IFI35Interferon induced protein 35. (284 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
NMIN-myc and STAT interactor. (307 aa)
CGASCyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second m [...] (495 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (283 aa)
TRIM6Tripartite motif containing 6. (487 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
SH2D1BSH2 domain-containing protein. (133 aa)
PSPC1Paraspeckle component 1 isoform 1. (521 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LOC102165642Uncharacterized protein. (249 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
A0A286ZSP8_PIGGamma-interferon-inducible protein 16 isoform 1. (585 aa)
KLRK1NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (221 aa)
A0A286ZWW0_PIGAIG1-type G domain-containing protein. (321 aa)
PLA2G5Phospholipase A(2). (138 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CARD9Caspase recruitment domain family member 9. (560 aa)
SFPQSplicing factor, proline-and glutamine-rich isoform X1. (702 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
CD226CD226 antigen isoform a. (335 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa)
MNDAMyeloid cell nuclear differentiation antigen. (410 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
TBK1TANK binding kinase TBK1. (729 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
TIRAPTIR domain containing adaptor protein. (243 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (196 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
RBM14RNA-binding protein 14 isoform 1. (669 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (847 aa)
NCR3Uncharacterized protein. (136 aa)
TRIM56Tripartite motif containing 56. (755 aa)
NOD2Uncharacterized protein. (1013 aa)
A0A287BRG1_PIGUncharacterized protein. (210 aa)
AKIRIN2Akirin 2. (213 aa)
NECTIN2Uncharacterized protein. (616 aa)
XRCC5X-ray repair cross complementing 5. (1011 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
LSM14AUncharacterized protein. (475 aa)
EREGEpiregulin. (168 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (292 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
CXorf21Chromosome X open reading frame 21. (299 aa)
XRCC6X-ray repair cross complementing 6. (606 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (348 aa)
CADM1Cell adhesion molecule 1. (473 aa)
KLRD1Killer cell lectin like receptor D1. (175 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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