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| | SRC | Tyrosine-protein kinase. (559 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | K7GRI9_PIG | Uncharacterized protein; Belongs to the CD36 family. (71 aa) |
| | ZAP70 | Tyrosine-protein kinase. (615 aa) |
| | IL6ST | Interleukin 6 signal transducer. (938 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa) |
| | TGFBR1 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | MYO1C | Unconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa) |
| | CAV3 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa) |
| | KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa) |
| | CBL | Cbl proto-oncogene. (914 aa) |
| | NEU3 | Neuraminidase 3. (428 aa) |
| | CXADR | Uncharacterized protein. (419 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | LRP8 | LDL receptor related protein 8. (998 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | GLIPR1L1 | GLIPR1 like 1; Belongs to the CRISP family. (243 aa) |
| | LAMTOR1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa) |
| | SCN5A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa) |
| | VAMP2 | V-SNARE coiled-coil homology domain-containing protein. (189 aa) |
| | HK1 | Uncharacterized protein. (919 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | A0A5G2R0P8_PIG | Uncharacterized protein. (55 aa) |
| | CAVIN3 | Caveolae associated protein 3. (290 aa) |
| | LAMTOR4 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (100 aa) |
| | PLPP3 | acidPPc domain-containing protein. (369 aa) |
| | DMD | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3679 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | TLR2 | Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa) |
| | PRNP | Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa) |
| | TRPC4 | Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (368 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | ASAH2 | Neutral ceramidase. (786 aa) |
| | TNR | Tenascin R. (1270 aa) |
| | FXYD7 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. (238 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa) |
| | ERLIN2 | ER lipid raft associated 2. (384 aa) |
| | A0A5G2Q9Z5_PIG | Uncharacterized protein. (120 aa) |
| | CDH13 | Uncharacterized protein. (771 aa) |
| | CD79A | Ig-like domain-containing protein. (234 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa) |
| | HCK | Tyrosine-protein kinase. (527 aa) |
| | RAP2B | Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (183 aa) |
| | CDHR2 | Cadherin related family member 2. (1342 aa) |
| | HDAC6 | Histone deacetylase 6. (1159 aa) |
| | CDH1 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa) |
| | SLC8A1 | Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | NFAM1 | NFAT activating protein with ITAM motif 1. (261 aa) |
| | ORAI1 | Uncharacterized protein. (408 aa) |
| | EFNB1 | Ephrin-B1; Belongs to the ephrin family. (346 aa) |
| | ENSSSCP00000055398 | annotation not available (71 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa) |
| | SKAP1 | Src kinase-associated phosphoprotein 1. (367 aa) |
| | STIM1 | Stromal interaction molecule 1. (791 aa) |
| | NTSR1 | Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (417 aa) |
| | LIPE | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa) |
| | LAMTOR5 | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa) |
| | BVES | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epitheli [...] (360 aa) |
| | PSEN2 | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (485 aa) |
| | ENSSSCP00000051045 | annotation not available (71 aa) |
| | THY1 | Thy-1 cell surface antigen. (165 aa) |
| | STOM | Stomatin. (267 aa) |
| | ENSSSCP00000050431 | annotation not available (71 aa) |
| | ARC | Activity regulated cytoskeleton associated protein. (396 aa) |
| | FYB2 | FYN binding protein 2. (802 aa) |
| | CLN3 | Battenin. (414 aa) |
| | CAVIN4 | Muscle-related coiled-coil protein. (362 aa) |
| | RANGRF | Ran guanine nucleotide release factor isoform A. (182 aa) |
| | LAMTOR3 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | KCNE3 | Potassium voltage-gated channel subfamily E member 3 isoform X1. (99 aa) |
| | TFPI | Tissue factor pathway inhibitor. (303 aa) |
| | PAG1 | Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (435 aa) |
| | FAIM2 | Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa) |
| | OLR1 | Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (272 aa) |
| | LRRK2 | Uncharacterized protein. (2501 aa) |
| | MLC1 | Modulator of VRAC current 1. (373 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (230 aa) |
| | AKAP5 | A-kinase anchoring protein 5. (427 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (771 aa) |
| | CBLB | E3 ubiquitin-protein ligase CBL-B isoform X1. (1047 aa) |
| | ADRA1A | Alpha-1A adrenergic receptor isoform 1. (466 aa) |
| | GPC1 | Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa) |
| | PECAM1 | Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | LYPD4 | Ly6/PLAUR domain-containing protein 4 isoform X4. (246 aa) |
| | CD177 | CD177 molecule. (438 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (818 aa) |
| | EZR | Ezrin. (562 aa) |
| | GJA1 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | CLN6 | CLN6 transmembrane ER protein. (312 aa) |
| | TEK | TEK receptor tyrosine kinase. (1147 aa) |
| | ABCA1 | Uncharacterized protein. (2261 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa) |
| | MAL2 | Mal, T cell differentiation protein 2 (gene/pseudogene). (176 aa) |
| | CDH15 | Cadherin-15 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (785 aa) |
| | SLC38A9 | Sodium-coupled neutral amino acid transporter 9 isoform X2. (531 aa) |
| | BAALC | Brain and acute leukemia cytoplasmic protein; May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. (145 aa) |
| | SULF1 | Sulfatase 1. (1108 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | STX4 | Syntaxin 4; Belongs to the syntaxin family. (338 aa) |
| | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (433 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | TEX101 | Uncharacterized protein. (248 aa) |
| | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (389 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa) |
| | SGCA | Sarcoglycan alpha. (387 aa) |
| | CD8A | CD8a molecule. (237 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1092 aa) |
| | CBLC | Cbl proto-oncogene C. (561 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | RHOQ | Rho-related GTP-binding protein RhoQ. (205 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | MYO1A | Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons 2. (538 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | CAVIN1 | Caveolae associated protein 1. (458 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | CTSD | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa) |
| | RAP2A | Ras-related protein Rap-2a. (183 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | ADGRG1 | Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (740 aa) |
| | CD48 | CD48 antigen isoform X1. (243 aa) |
| | LAMTOR2 | Ragulator complex protein LAMTOR2 isoform 1. (125 aa) |
| | BCL10 | B-cell lymphoma/leukemia 10 isoform 1. (233 aa) |
| | DLC1 | Rho GTPase-activating protein 7 isoform X1. (1528 aa) |
| | IKBKB | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa) |
| | HPSE | Heparanase isoform 1 preproprotein. (551 aa) |
| | LAMP1 | Uncharacterized protein. (413 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (509 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa) |
| | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha. (479 aa) |
| | ARID3C | AT-rich interaction domain 3C. (416 aa) |
| | HYAL2 | Hyaluronidase. (476 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
| | PGK1 | Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa) |
| | SLC1A2 | Amino acid transporter. (639 aa) |
| | KIF18A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (904 aa) |
| | PRTN3 | Proteinase 3; Belongs to the peptidase S1 family. (268 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa) |
| | CTNNA1 | Catenin alpha 1. (1090 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa) |
| | BACE1 | Beta-secretase 1; Belongs to the peptidase A1 family. (503 aa) |
| | CD36 | Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa) |
| | NPHS2 | NPHS2 stomatin family member, podocin. (378 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (516 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa) |
| | PLPP1 | Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (532 aa) |
| | ADRA1B | Adrenoceptor alpha 1B. (518 aa) |
| | SLC6A3 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa) |
| | SLC6A4 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (667 aa) |
| | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | LAT2 | Linker for activation of T cells family member 2. (253 aa) |
| | ADD2 | Adducin 2. (725 aa) |
| | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. (709 aa) |
| | TPP1 | Tripeptidyl-peptidase 1 preproprotein. (572 aa) |
| | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha. (1030 aa) |
| | CORO1C | Coronin; Belongs to the WD repeat coronin family. (511 aa) |
| | TLR6 | Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa) |
| | EHD2 | EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa) |
| | CAVIN2 | Caveolae associated protein 2. (424 aa) |
| | EPHB1 | Ephrin type-B receptor 1. (984 aa) |
| | CLIP3 | CAP-Gly domain-containing linker protein 3. (547 aa) |
| | STX12 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa) |
| | TLR1 | Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa) |
| | ARID3A | AT-rich interactive domain-containing protein 3A. (596 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (726 aa) |
| | CD1.1 | T-cell surface glycoprotein CD1a; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (339 aa) |
| | PTCH1 | Protein patched homolog 1 isoform L. (1452 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | ABCG2 | Broad substrate specificity ATP-binding cassette transporter ABCG2; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extra [...] (656 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | STOML2 | Stomatin like 2. (356 aa) |
| | SERPINH1 | SERPIN domain-containing protein; Belongs to the serpin family. (418 aa) |
| | FLOT1 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa) |
