STRINGSTRING
WNT9B WNT9B KDM6B KDM6B PRDM1 PRDM1 NKX6-2 NKX6-2 EPOP EPOP WNT6 WNT6 SOX13 SOX13 TEAD3 TEAD3 NTF4 NTF4 KIAA1549L KIAA1549L IL7 IL7 PAF1 PAF1 FGF8 FGF8 SOSTDC1 SOSTDC1 RAG2 RAG2 IL6R IL6R SPRY2 SPRY2 RUNX2 RUNX2 TM2D3 TM2D3 KIAA1549 KIAA1549 GAP43 GAP43 VWA5B2 VWA5B2 PTCH1 PTCH1 GATA4 GATA4 NR2E1 NR2E1 TBX4 TBX4 WNT9A WNT9A HOXC10 HOXC10 HOXA13 HOXA13 DLL1 DLL1 PTF1A PTF1A RTF1 RTF1 IL6 IL6 CDON CDON GATA1 GATA1 LBX1 LBX1 WNT3A WNT3A WNT8A WNT8A GDF7 GDF7 TBX2 TBX2 DMRTA2 DMRTA2 WNT10A WNT10A STAT6 STAT6 WNT11 WNT11 FOXN1 FOXN1 TBX21 TBX21 STAT3 STAT3 SOX9 SOX9 TLX3 TLX3 ISL1 ISL1 FGF10 FGF10 GLI3 GLI3 HOXA2 HOXA2 HOXA11 HOXA11 TBX20 TBX20 WNT16 WNT16 SMO SMO SHH SHH MNX1 MNX1 IHH IHH ERBB4 ERBB4 NEUROD1 NEUROD1 HOXD10 HOXD10 DLX2 DLX2 TBR1 TBR1 NEUROG1 NEUROG1 MEF2C MEF2C CTR9 CTR9 MYOD1 MYOD1 DBX1 DBX1 TBX22 TBX22 OLIG1 OLIG1 GATA2 GATA2 FEZF2 FEZF2 CTSV CTSV CTSL CTSL TCF7L2 TCF7L2 SUFU SUFU FOXN4 FOXN4 TBX5 TBX5 TBX3 TBX3 EBF2 EBF2 GSX1 GSX1 ATOH1 ATOH1 EDNRA EDNRA SFRP2 SFRP2 GSX2 GSX2 ID2 ID2 SIX2 SIX2 EPAS1 EPAS1 CYP26B1 CYP26B1 PRADC1 PRADC1 MYL10 MYL10 GATA5 GATA5 BARHL2 BARHL2 WNT2B WNT2B TBX15 TBX15 SLAMF6 SLAMF6 TBX19 TBX19 SOX17 SOX17 PRDM14 PRDM14 WNT8B WNT8B EXT1 EXT1 SIX1 SIX1 BMP4 BMP4 MGA MGA ONECUT1 ONECUT1 ONECUT2 ONECUT2 SMAD4 SMAD4 TBX18 TBX18 HEY2 HEY2 OLIG3 OLIG3 ZNF521 ZNF521 GATA6 GATA6 WNT4 WNT4 MTOR MTOR ETV2 ETV2 BCL11B BCL11B GSC GSC PSEN1 PSEN1 NR2F2 NR2F2 PML PML MESP1 MESP1 EHMT2 EHMT2 POU5F1 POU5F1 SOX5 SOX5 DHH DHH WNT1 WNT1 WNT10B WNT10B WNT7B WNT7B JAG2 JAG2 KDR KDR SFRP1 SFRP1 ITGB1 ITGB1 TGFBR1 TGFBR1 DOCK7 DOCK7 CTNNB1 CTNNB1 SMAD1 SMAD1 OLIG2 OLIG2 SMAD5 SMAD5 ARX ARX WNT5B WNT5B PAX6 PAX6 ARHGEF2 ARHGEF2 MYL2 MYL2 SOX8 SOX8 PITX1 PITX1 LHX3 LHX3 GCM1 GCM1 RARA RARA BRAF BRAF EOMES EOMES TAL1 TAL1 LOC110258874 LOC110258874 DLX1 DLX1 BMP2 BMP2 APC2 APC2 APC APC PRRX1 PRRX1 WNT5A WNT5A FOXG1 FOXG1 EYA1 EYA1 IRF4 IRF4 NEUROD4 NEUROD4 GATA3 GATA3 FOXA1 FOXA1 SOX6 SOX6 WNT7A WNT7A EDN1 EDN1 PTCH2 PTCH2 TBX1 TBX1 LATS1 LATS1 LEO1 LEO1 RHOA RHOA SOX18 SOX18 NKX6-3 NKX6-3 WNT3 WNT3 HES1 HES1 DMRT3 DMRT3 NODAL NODAL SPDEF SPDEF TBXT TBXT GBX1 GBX1 NOTCH1 NOTCH1 TP53 TP53 MITF MITF TBX6 TBX6 FEV FEV TGFB1I1 TGFB1I1 TEAD4 TEAD4 PROX1 PROX1 POU4F1 POU4F1 TOX TOX HES5 HES5 NKX2-2 NKX2-2 TBX10 TBX10 LATS2 LATS2 ISL2 ISL2 NKX2-1 NKX2-1 DLL4 DLL4 NANOG NANOG MYT1L MYT1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
KDM6BLysine demethylase 6B. (1638 aa)
PRDM1PR/SET domain 1. (842 aa)
NKX6-2Homeobox protein Nkx-6.2. (277 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
SOX13SRY-box transcription factor 13. (676 aa)
TEAD3YBD domain-containing protein. (395 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
KIAA1549LKIAA1549 like. (1836 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (560 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
RAG2V(D)J recombination activating protein 2. (527 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
TM2D3TM2 domain containing 3. (298 aa)
KIAA1549KIAA1549. (1933 aa)
GAP43Uncharacterized protein. (244 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1248 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
TBX4Uncharacterized protein. (549 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HOXC10Homeobox C10. (342 aa)
HOXA13Homeobox A13. (388 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (769 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
GATA1Erythroid transcription factor. (412 aa)
LBX1Ladybird homeobox 1. (281 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF7Growth differentiation factor 7. (449 aa)
TBX2T-box 2 protein. (714 aa)
DMRTA2Doublesex-and mab-3-related transcription factor A2. (535 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
FOXN1Forkhead box N1. (671 aa)
TBX21Uncharacterized protein. (535 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GLI3GLI family zinc finger 3. (1586 aa)
HOXA2Homeobox protein Hox-A2. (380 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
TBX20T-box transcription factor TBX20 isoform 1. (449 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
MNX1Motor neuron and pancreas homeobox 1. (401 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
DLX2Distal-less homeobox 2. (328 aa)
TBR1T-box brain transcription factor 1. (682 aa)
NEUROG1Neurogenin 1. (246 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1169 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
DBX1Developing brain homeobox 1. (343 aa)
TBX22T-box transcription factor 22. (526 aa)
OLIG1Oligodendrocyte transcription factor 1. (269 aa)
GATA2GATA binding protein 2. (502 aa)
FEZF2FEZ family zinc finger 2. (503 aa)
CTSVCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
CTSLCathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
SUFUSUFU negative regulator of hedgehog signaling. (432 aa)
FOXN4Fork-head domain-containing protein. (517 aa)
TBX5T-box transcription factor 5. (535 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
EBF2EBF transcription factor 2. (575 aa)
GSX1GS homeobox 1. (267 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
SFRP2Uncharacterized protein. (294 aa)
GSX2GS homeobox 2. (304 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
SIX2SIX homeobox 2. (296 aa)
EPAS1Uncharacterized protein. (870 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
PRADC1Protease associated domain containing 1. (244 aa)
MYL10Myosin light chain 10. (167 aa)
GATA5GATA binding protein 5. (393 aa)
BARHL2BarH like homeobox 2. (384 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
TBX15Uncharacterized protein. (345 aa)
SLAMF6SLAM family member 6. (321 aa)
TBX19T-box transcription factor TBX19. (446 aa)
SOX17SRY-box transcription factor 17. (407 aa)
PRDM14PR/SET domain 14. (571 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SIX1Six homeobox 1. (284 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MGAMAX dimerization protein MGA. (3053 aa)
ONECUT1One cut domain family member. (465 aa)
ONECUT2One cut domain family member. (694 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
TBX18T-box transcription factor TBX18. (612 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
ZNF521Zinc finger protein 521. (1310 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
ETV2ETS variant 2. (242 aa)
BCL11BUncharacterized protein. (888 aa)
GSCGoosecoid homeobox. (256 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
PMLPromyelocytic leukemia. (827 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
EHMT2Uncharacterized protein. (1233 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
SOX5SRY-box transcription factor 5. (763 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1371 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2312 aa)
CTNNB1Catenin beta 1. (808 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ARXAristaless related homeobox. (563 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
PAX6Paired box 6. (498 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] (1066 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
SOX8SRY-box transcription factor 8. (460 aa)
PITX1Homeobox protein. (314 aa)
LHX3LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). (538 aa)
GCM1Glial cells missing transcription factor 1. (431 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
EOMESEomesodermin. (704 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
LOC110258874Fork-head domain-containing protein. (493 aa)
DLX1Homeobox protein DLX-1 isoform 1. (255 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
APC2Uncharacterized protein. (2292 aa)
APCAPC_basic domain-containing protein. (2713 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FOXG1Forkhead box G1. (486 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
IRF4Interferon regulatory factor 4. (451 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
FOXA1Forkhead box A1. (468 aa)
SOX6SRY-box transcription factor 6. (859 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
PTCH2Patched 2. (1207 aa)
TBX1T-box transcription factor 1. (490 aa)
LATS1Large tumor suppressor kinase 1. (1146 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
SOX18SRY-box transcription factor 18. (389 aa)
NKX6-3Homeobox protein Nkx-6.3 isoform X1. (261 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
HES1Uncharacterized protein. (280 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (473 aa)
NODALNodal growth differentiation factor. (316 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (363 aa)
TBXTT-box transcription factor T. (435 aa)
GBX1Gastrulation brain homeobox 1. (365 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
TBX6T-box transcription factor TBX6 isoform X1. (436 aa)
FEVFEV transcription factor, ETS family member. (237 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (497 aa)
PROX1Prospero homeobox 1. (737 aa)
POU4F1POU domain protein. (421 aa)
TOXThymocyte selection associated high mobility group box. (541 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
TBX10T-box transcription factor 10. (385 aa)
LATS2Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa)
ISL2ISL LIM homeobox 2. (359 aa)
NKX2-1NK2 homeobox 1. (399 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NANOGHomeobox domain-containing protein. (304 aa)
MYT1LMyelin transcription factor 1 like. (1193 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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