(73 nodes) Maintenance of protein location network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SUN1	Sad1 and UNC84 domain containing 1. (848 aa)
	SCIN	Adseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
	LOC110257335	Golgi phosphoprotein 3 (Coat-protein). (298 aa)
	INSIG2	Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (225 aa)
	OS9	OS9 endoplasmic reticulum lectin. (665 aa)
	GOPC	PDZ domain-containing protein. (463 aa)
	GSN	Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa)
	A0A287A3F2_PIG	Uncharacterized protein. (100 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1708 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa)
	KDELR2	ER lumen protein-retaining receptor. (212 aa)
	MORC3	MORC family CW-type zinc finger 3. (939 aa)
	HK1	Uncharacterized protein. (919 aa)
	A0A5G2R996_PIG	KASH domain-containing protein. (999 aa)
	RANGAP1	Ran GTPase activating protein 1. (585 aa)
	VPS13A	Vacuolar protein sorting 13 homolog A. (3171 aa)
	A0A5G2QNQ5_PIG	Uncharacterized protein. (428 aa)
	BBS4	Uncharacterized protein. (826 aa)
	FBN2	Fibrillin 2. (2910 aa)
	TWF1	Twinfilin actin binding protein 1. (366 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4383 aa)
	SYNE1	Uncharacterized protein. (1723 aa)
	VPS13C	Vacuolar protein sorting 13 homolog C. (3757 aa)
	GET4	Uncharacterized protein. (668 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	SORL1	Sortilin related receptor 1. (2213 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
	KEAP1	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa)
	NRROS	Negative regulator of reactive oxygen species. (704 aa)
	DBN1	Drebrin 1. (857 aa)
	DZIP1	C2H2-type domain-containing protein. (265 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1873 aa)
	TSPO	Translocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (By similarity); Belongs to the TspO/BZRP family. (169 aa)
	KDELR3	ER lumen protein-retaining receptor. (298 aa)
	PML	Promyelocytic leukemia. (827 aa)
	NFKBIA	NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
	ARL2BP	ADP ribosylation factor like GTPase 2 binding protein. (175 aa)
	KDELR1	ER lumen protein-retaining receptor. (560 aa)
	PARK7	DJ-1 protein. (189 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4389 aa)
	PINK1	PTEN induced kinase 1. (588 aa)
	ANKRD13C	Ankyrin repeat domain 13C. (532 aa)
	FBN1	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
	CIZ1	CDKN1A interacting zinc finger protein 1. (758 aa)
	TMSB10	Thymosin beta-10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. (105 aa)
	HK2	Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
	SUPT7L	STAGA complex 65 subunit gamma isoform b. (412 aa)
	PFN4	Profilin; Belongs to the profilin family. (129 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (970 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (432 aa)
	TAF3	TATA-box binding protein associated factor 3. (929 aa)
	TWF2	Twinfilin actin binding protein 2. (500 aa)
	Z4YP56_PIG	Uncharacterized protein. (79 aa)
	CCDC22	Coiled-coil domain containing 22. (716 aa)
	TMSB15B	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
	SRI	Sorcin isoform A. (199 aa)
	CD4	CD4 molecule. (494 aa)
	CDK5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	TAPT1	Transmembrane anterior posterior transformation 1. (779 aa)
	NFKBIB	NFKB inhibitor beta. (361 aa)
	NRM	Nurim. (203 aa)
	TMSB4X	Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. (44 aa)
	CREB3	cAMP responsive element binding protein 3. (373 aa)
	LOC110257905	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
	TAF8	TATA-box binding protein associated factor 8. (320 aa)
	ARL2	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family. (211 aa)
	FLNA	Filamin A. (2897 aa)
	NR5A1	Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] (461 aa)
	RER1	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (204 aa)
	TOPORS	TOP1 binding arginine/serine rich protein. (1049 aa)
	LATS1	Large tumor suppressor kinase 1. (1146 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2QNQ5_PIG	A0A5G2R996_PIG	ENSSSCP00000066319	ENSSSCP00000070694	Uncharacterized protein.	KASH domain-containing protein.	0.939
A0A5G2QNQ5_PIG	SUN1	ENSSSCP00000066319	ENSSSCP00000044536	Uncharacterized protein.	Sad1 and UNC84 domain containing 1.	0.738
A0A5G2QNQ5_PIG	SYNE1	ENSSSCP00000066319	ENSSSCP00000062696	Uncharacterized protein.	Uncharacterized protein.	0.934
A0A5G2R996_PIG	A0A5G2QNQ5_PIG	ENSSSCP00000070694	ENSSSCP00000066319	KASH domain-containing protein.	Uncharacterized protein.	0.939
A0A5G2R996_PIG	SUN1	ENSSSCP00000070694	ENSSSCP00000044536	KASH domain-containing protein.	Sad1 and UNC84 domain containing 1.	0.760
A0A5G2R996_PIG	SYNE1	ENSSSCP00000070694	ENSSSCP00000062696	KASH domain-containing protein.	Uncharacterized protein.	0.941
ARL2	ARL2BP	ENSSSCP00000050487	ENSSSCP00000003038	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor like GTPase 2 binding protein.	0.984
ARL2	TWF1	ENSSSCP00000050487	ENSSSCP00000065456	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family.	Twinfilin actin binding protein 1.	0.426
ARL2BP	ARL2	ENSSSCP00000003038	ENSSSCP00000050487	ADP ribosylation factor like GTPase 2 binding protein.	ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family.	0.984
ARL2BP	TAPT1	ENSSSCP00000003038	ENSSSCP00000019996	ADP ribosylation factor like GTPase 2 binding protein.	Transmembrane anterior posterior transformation 1.	0.602
ARL2BP	TOPORS	ENSSSCP00000003038	ENSSSCP00000045166	ADP ribosylation factor like GTPase 2 binding protein.	TOP1 binding arginine/serine rich protein.	0.573
BBS4	KEAP1	ENSSSCP00000066147	ENSSSCP00000056325	Uncharacterized protein.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.590
BBS4	PKD2	ENSSSCP00000066147	ENSSSCP00000009827	Uncharacterized protein.	Polycystin 2, transient receptor potential cation channel.	0.472
CCDC22	KEAP1	ENSSSCP00000013086	ENSSSCP00000056325	Coiled-coil domain containing 22.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.506
CCDC22	PSMD10	ENSSSCP00000013086	ENSSSCP00000059620	Coiled-coil domain containing 22.	Proteasome 26S subunit, non-ATPase 10.	0.405
CD4	NFKBIA	ENSSSCP00000019155	ENSSSCP00000002133	CD4 molecule.	NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.	0.480
CIZ1	FBN1	ENSSSCP00000006043	ENSSSCP00000005017	CDKN1A interacting zinc finger protein 1.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.410
CIZ1	VPS13A	ENSSSCP00000006043	ENSSSCP00000067642	CDKN1A interacting zinc finger protein 1.	Vacuolar protein sorting 13 homolog A.	0.440
CREB3	KDELR3	ENSSSCP00000031632	ENSSSCP00000000109	cAMP responsive element binding protein 3.	ER lumen protein-retaining receptor.	0.507
FBN1	CIZ1	ENSSSCP00000005017	ENSSSCP00000006043	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	CDKN1A interacting zinc finger protein 1.	0.410