| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC42 | MSN | ENSSSCP00000029815 | ENSSSCP00000044358 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | 0.649 |
| CDC42 | MYO9A | ENSSSCP00000029815 | ENSSSCP00000038105 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.719 |
| CDC42 | OPHN1 | ENSSSCP00000029815 | ENSSSCP00000069677 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Oligophrenin 1. | 0.621 |
| CDC42 | RHOA | ENSSSCP00000029815 | ENSSSCP00000045785 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Transforming protein RhoA isoform 1. | 0.948 |
| MSN | CDC42 | ENSSSCP00000044358 | ENSSSCP00000029815 | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.649 |
| MSN | RHOA | ENSSSCP00000044358 | ENSSSCP00000045785 | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | Transforming protein RhoA isoform 1. | 0.803 |
| MSN | SLC9A3R1 | ENSSSCP00000044358 | ENSSSCP00000067473 | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. | 0.995 |
| MYO9A | CDC42 | ENSSSCP00000038105 | ENSSSCP00000029815 | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.719 |
| MYO9A | OPHN1 | ENSSSCP00000038105 | ENSSSCP00000069677 | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Oligophrenin 1. | 0.414 |
| MYO9A | RHOA | ENSSSCP00000038105 | ENSSSCP00000045785 | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Transforming protein RhoA isoform 1. | 0.735 |
| OPHN1 | CDC42 | ENSSSCP00000069677 | ENSSSCP00000029815 | Oligophrenin 1. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.621 |
| OPHN1 | MYO9A | ENSSSCP00000069677 | ENSSSCP00000038105 | Oligophrenin 1. | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.414 |
| OPHN1 | RHOA | ENSSSCP00000069677 | ENSSSCP00000045785 | Oligophrenin 1. | Transforming protein RhoA isoform 1. | 0.648 |
| PTK7 | WNT5A | ENSSSCP00000001804 | ENSSSCP00000037791 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.735 |
| RHOA | CDC42 | ENSSSCP00000045785 | ENSSSCP00000029815 | Transforming protein RhoA isoform 1. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.948 |
| RHOA | MSN | ENSSSCP00000045785 | ENSSSCP00000044358 | Transforming protein RhoA isoform 1. | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | 0.803 |
| RHOA | MYO9A | ENSSSCP00000045785 | ENSSSCP00000038105 | Transforming protein RhoA isoform 1. | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.735 |
| RHOA | OPHN1 | ENSSSCP00000045785 | ENSSSCP00000069677 | Transforming protein RhoA isoform 1. | Oligophrenin 1. | 0.648 |
| RHOA | WNT5A | ENSSSCP00000045785 | ENSSSCP00000037791 | Transforming protein RhoA isoform 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.416 |
| SLC9A3R1 | MSN | ENSSSCP00000067473 | ENSSSCP00000044358 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. | 0.995 |