(33 nodes) Sarcomere organization network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	SYNPO2L	Synaptopodin 2 like. (965 aa)
	TNNT1	Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (298 aa)
	ACTN2	Uncharacterized protein. (933 aa)
	MYOZ2	Calsarcin 1. (264 aa)
	PLEC	Plectin. (5422 aa)
	MYLK3	Myosin light chain kinase 3. (797 aa)
	TNNT3	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (438 aa)
	MYPN	Myopalladin isoform a. (1320 aa)
	CSRP1	Cysteine and glycine rich protein 1. (309 aa)
	LDB3	LIM domain binding 3. (721 aa)
	A0A287AK74_PIG	Uncharacterized protein. (71 aa)
	CAPN3	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (830 aa)
	SRF	Serum response factor. (512 aa)
	CFL2	Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). (166 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (402 aa)
	MYOZ1	Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). (297 aa)
	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (433 aa)
	CSRP3	Uncharacterized protein. (200 aa)
	FLNC	Filamin-C isoform X4. (2720 aa)
	LMOD2	Leiomodin 2. (550 aa)
	FHOD3	Formin homology 2 domain containing 3. (1614 aa)
	ACTN1	Uncharacterized protein. (888 aa)
	TNNT2	Uncharacterized protein. (295 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
	MYOM2	Uncharacterized protein. (888 aa)
	WDR1	WD repeat-containing protein 1 isoform 1. (606 aa)
	SIX4	Homeobox domain-containing protein. (785 aa)
	CAPN9	Calpain 9; Belongs to the peptidase C2 family. (723 aa)
	ACTG1	Actin gamma 1. (381 aa)
	TCAP	Uncharacterized protein. (262 aa)
	KLHL41	Kelch like family member 41. (601 aa)
	CSRP2	Cysteine and glycine rich protein 2. (194 aa)
	MYH7	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG1	ACTN1	ENSSSCP00000040911	ENSSSCP00000025103	Actin gamma 1.	Uncharacterized protein.	0.761
ACTG1	CFL2	ENSSSCP00000040911	ENSSSCP00000002141	Actin gamma 1.	Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).	0.958
ACTG1	ITGB1	ENSSSCP00000040911	ENSSSCP00000030775	Actin gamma 1.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.926
ACTG1	LDB3	ENSSSCP00000040911	ENSSSCP00000045131	Actin gamma 1.	LIM domain binding 3.	0.439
ACTG1	MYH7	ENSSSCP00000040911	ENSSSCP00000070632	Actin gamma 1.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.437
ACTG1	TNNT1	ENSSSCP00000040911	ENSSSCP00000069636	Actin gamma 1.	Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.413
ACTG1	TNNT3	ENSSSCP00000040911	ENSSSCP00000050941	Actin gamma 1.	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.413
ACTG1	WDR1	ENSSSCP00000040911	ENSSSCP00000034755	Actin gamma 1.	WD repeat-containing protein 1 isoform 1.	0.677
ACTN1	ACTG1	ENSSSCP00000025103	ENSSSCP00000040911	Uncharacterized protein.	Actin gamma 1.	0.761
ACTN1	CFL2	ENSSSCP00000025103	ENSSSCP00000002141	Uncharacterized protein.	Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).	0.597
ACTN1	CSRP2	ENSSSCP00000025103	ENSSSCP00000072964	Uncharacterized protein.	Cysteine and glycine rich protein 2.	0.470
ACTN1	CSRP3	ENSSSCP00000025103	ENSSSCP00000014190	Uncharacterized protein.	Uncharacterized protein.	0.458
ACTN1	ITGB1	ENSSSCP00000025103	ENSSSCP00000030775	Uncharacterized protein.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.531
ACTN1	LDB3	ENSSSCP00000025103	ENSSSCP00000045131	Uncharacterized protein.	LIM domain binding 3.	0.428
ACTN1	MYH7	ENSSSCP00000025103	ENSSSCP00000070632	Uncharacterized protein.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.446
ACTN1	MYOZ1	ENSSSCP00000025103	ENSSSCP00000010985	Uncharacterized protein.	Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).	0.549
ACTN1	MYOZ2	ENSSSCP00000025103	ENSSSCP00000059330	Uncharacterized protein.	Calsarcin 1.	0.561
ACTN1	TNNT1	ENSSSCP00000025103	ENSSSCP00000069636	Uncharacterized protein.	Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.433
ACTN1	TNNT2	ENSSSCP00000025103	ENSSSCP00000026957	Uncharacterized protein.	Uncharacterized protein.	0.561
ACTN1	TNNT3	ENSSSCP00000025103	ENSSSCP00000050941	Uncharacterized protein.	Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.433