(9 nodes) Alpha-catenin binding network (Sus scrofa)

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Your Input:
	JUP	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
	AJUBA	Ajuba LIM protein. (565 aa)
	PTPRT	Protein tyrosine phosphatase receptor type T. (1460 aa)
	NUMB	NUMB endocytic adaptor protein. (653 aa)
	PKP3	Plakophilin 3. (1145 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	PKP2	Plakophilin 2. (837 aa)
	VCL	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
	NUMBL	PID domain-containing protein. (1029 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	JUP	ENSSSCP00000031836	ENSSSCP00000018469	Catenin beta 1.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.955
CTNNB1	NUMB	ENSSSCP00000031836	ENSSSCP00000040817	Catenin beta 1.	NUMB endocytic adaptor protein.	0.599
CTNNB1	PKP2	ENSSSCP00000031836	ENSSSCP00000068407	Catenin beta 1.	Plakophilin 2.	0.594
CTNNB1	VCL	ENSSSCP00000031836	ENSSSCP00000010997	Catenin beta 1.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.810
JUP	CTNNB1	ENSSSCP00000018469	ENSSSCP00000031836	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	Catenin beta 1.	0.955
JUP	PKP2	ENSSSCP00000018469	ENSSSCP00000068407	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	Plakophilin 2.	0.818
JUP	PKP3	ENSSSCP00000018469	ENSSSCP00000033235	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	Plakophilin 3.	0.731
JUP	VCL	ENSSSCP00000018469	ENSSSCP00000010997	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.770
NUMB	CTNNB1	ENSSSCP00000040817	ENSSSCP00000031836	NUMB endocytic adaptor protein.	Catenin beta 1.	0.599
NUMB	NUMBL	ENSSSCP00000040817	ENSSSCP00000023954	NUMB endocytic adaptor protein.	PID domain-containing protein.	0.900
NUMBL	NUMB	ENSSSCP00000023954	ENSSSCP00000040817	PID domain-containing protein.	NUMB endocytic adaptor protein.	0.900
PKP2	CTNNB1	ENSSSCP00000068407	ENSSSCP00000031836	Plakophilin 2.	Catenin beta 1.	0.594
PKP2	JUP	ENSSSCP00000068407	ENSSSCP00000018469	Plakophilin 2.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.818
PKP2	PKP3	ENSSSCP00000068407	ENSSSCP00000033235	Plakophilin 2.	Plakophilin 3.	0.622
PKP2	VCL	ENSSSCP00000068407	ENSSSCP00000010997	Plakophilin 2.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.552
PKP3	JUP	ENSSSCP00000033235	ENSSSCP00000018469	Plakophilin 3.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.731
PKP3	PKP2	ENSSSCP00000033235	ENSSSCP00000068407	Plakophilin 3.	Plakophilin 2.	0.622
VCL	CTNNB1	ENSSSCP00000010997	ENSSSCP00000031836	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	Catenin beta 1.	0.810
VCL	JUP	ENSSSCP00000010997	ENSSSCP00000018469	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.770
VCL	PKP2	ENSSSCP00000010997	ENSSSCP00000068407	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	Plakophilin 2.	0.552