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CORO1A CORO1A CTSS CTSS PIP4P2 PIP4P2 ABCA1 ABCA1 ATG14 ATG14 PIK3C3 PIK3C3 INPP5B INPP5B MTOR MTOR APPL2 APPL2 LAMP1 LAMP1 RAB36 RAB36 KIF5B KIF5B TLR9 TLR9 TLR8 TLR8 TCIRG1 TCIRG1 CDC42EP2 CDC42EP2 AMBRA1 AMBRA1 RAB11B RAB11B RAB8A RAB8A ZYX ZYX BECN1 BECN1 TLR6 TLR6 RAB20 RAB20 STX12 STX12 TLR1 TLR1 ADAM8 ADAM8 RAB9A RAB9A ANXA11 ANXA11 SLAMF1 SLAMF1 MYO1C MYO1C CLEC4E CLEC4E RAB7A RAB7A RAB43 RAB43 SYK SYK RAB5A RAB5A CLCN3 CLCN3 RAB23 RAB23 STXBP3 STXBP3 PIP4P1 PIP4P1 RAB11A RAB11A PLA2G5 PLA2G5 STXBP1 STXBP1 STX8 STX8 APPL1 APPL1 RAB39A RAB39A GSN GSN ACTG1 ACTG1 STX6 STX6 SLC11A1 SLC11A1 VAMP7 VAMP7 RAB7B RAB7B PRPS2 PRPS2 ZDHHC5 ZDHHC5 RAB8B RAB8B SYT11 SYT11 WAS WAS PLD4 PLD4 VPS26B VPS26B LAMP2 LAMP2 CDC42EP4 CDC42EP4 DNM2 DNM2 RAB38 RAB38 RAB9B RAB9B NOD2 NOD2 RAB14 RAB14 RAB22A RAB22A RAB34 RAB34 RAB31 RAB31 RILP RILP RAB11FIP5 RAB11FIP5 OCRL OCRL TLR2 TLR2 VAMP3 VAMP3 TRIM14 TRIM14 SNX3 SNX3 STXBP4 STXBP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CORO1ACoronin; Belongs to the WD repeat coronin family. (492 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
ABCA1Uncharacterized protein. (2261 aa)
ATG14Autophagy related 14. (510 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (877 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
LAMP1Uncharacterized protein. (413 aa)
RAB36RAB36, member RAS oncogene family. (265 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1117 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
RAB11BUncharacterized protein. (205 aa)
RAB8AUncharacterized protein. (242 aa)
ZYXZyxin. (588 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
RAB20RAB20, member RAS oncogene family. (233 aa)
STX12t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
ANXA11Annexin. (516 aa)
SLAMF1Ig-like domain-containing protein. (379 aa)
MYO1CUnconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
CLEC4EC-type lectin domain family 4 member E. (212 aa)
RAB7ARAB7A, member RAS oncogene family. (252 aa)
RAB43RAB43, member RAS oncogene family. (210 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
CLCN3Chloride channel protein. (866 aa)
RAB23RAB23, member RAS oncogene family. (206 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
PLA2G5Phospholipase A(2). (138 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
STX8Syntaxin 8. (301 aa)
APPL1Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa)
ACTG1Actin gamma 1. (381 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (306 aa)
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (538 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
PRPS2TIR domain-containing protein. (1337 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
RAB8BRAB8B, member RAS oncogene family. (215 aa)
SYT11Synaptotagmin 11. (438 aa)
WASWASP actin nucleation promoting factor. (500 aa)
PLD4Phospholipase D family member 4. (684 aa)
VPS26BUncharacterized protein. (366 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa)
CDC42EP4CDC42 effector protein 4. (357 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (877 aa)
RAB38Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Belongs to the small GTPase superfam [...] (211 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
NOD2Uncharacterized protein. (1013 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (197 aa)
RAB22AUncharacterized protein. (256 aa)
RAB34Ras-related protein Rab-34; Protein transport. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes. Involved in the redistribution of lysosomes to the peri-Golgi region. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. (260 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
RILPRab interacting lysosomal protein. (362 aa)
RAB11FIP5Uncharacterized protein. (1391 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (217 aa)
TRIM14Tripartite motif-containing protein 14 isoform X1. (445 aa)
SNX3Sorting nexin-3 isoform a. (162 aa)
STXBP4Syntaxin-binding protein 4 isoform X3. (573 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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