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TMEM120B TMEM120B WNT10B WNT10B WNT1 WNT1 ADGRF5 ADGRF5 ALDH6A1 ALDH6A1 ATF5 ATF5 LAMA4 LAMA4 SMAD6 SMAD6 LOC100359361 LOC100359361 TRIM32 TRIM32 F1SER8_PIG F1SER8_PIG F1SER7_PIG F1SER7_PIG MKKS MKKS ADIG ADIG PLAC8 PLAC8 EBF2 EBF2 EGR2 EGR2 SIRT1 SIRT1 GDF10 GDF10 FFAR4 FFAR4 TCF7L2 TCF7L2 ADRB1 ADRB1 CTBP2 CTBP2 PPARG PPARG STEAP4 STEAP4 LAMB3 LAMB3 ADRB3 ADRB3 C1QTNF3 C1QTNF3 FGF10 FGF10 MED1 MED1 SLC2A4 SLC2A4 ALOXE3 ALOXE3 EP300 EP300 OSBPL11 OSBPL11 WNT3A WNT3A CLIP3 CLIP3 NOC3L NOC3L OSBPL8 OSBPL8 SOCS1 SOCS1 BBS2 BBS2 SH2B2 SH2B2 RETREG1 RETREG1 JDP2 JDP2 FFAR2 FFAR2 ARL4C ARL4C SOX8 SOX8 PTGS2 PTGS2 A0A286ZVA3_PIG A0A286ZVA3_PIG BBS1 BBS1 FABP4 FABP4 RGS2 RGS2 DHRS7B DHRS7B SDF4 SDF4 PSMB8 PSMB8 NR4A2 NR4A2 ANGPTL8 ANGPTL8 TFAP2B TFAP2B CTBP1 CTBP1 ZBTB7A ZBTB7A YME1L1 YME1L1 NR4A1 NR4A1 METTL8 METTL8 CEBPB CEBPB DIO2 DIO2 ADIPOQ ADIPOQ PDGFRA PDGFRA ZNF423 ZNF423 ADRB2 ADRB2 BSCL2 BSCL2 A0A287B396_PIG A0A287B396_PIG TGFB1I1 TGFB1I1 ATF2 ATF2 A0A287B8V2_PIG A0A287B8V2_PIG RNASEL RNASEL CNTN2 CNTN2 NIPBL NIPBL FAM120B FAM120B TTC8 TTC8 ZNF516 ZNF516 GDF6 GDF6 INHBB INHBB PRLH PRLH CCND1 CCND1 HMGA2 HMGA2 NUDT7 NUDT7 BBS4 BBS4 ARL4A ARL4A TMEM120A TMEM120A LRRC8C LRRC8C PIAS1 PIAS1 FBXO9 FBXO9 BBS12 BBS12 ARID5B ARID5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM120BTransmembrane protein 120B. (396 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1340 aa)
ALDH6A1Methylmalonate-semialdehyde dehydrogenase acylating, mitochondrial isoform 1. (534 aa)
ATF5Activating transcription factor 5. (282 aa)
LAMA4Laminin subunit alpha 4. (1815 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
LOC100359361Uncharacterized protein. (108 aa)
TRIM32Tripartite motif containing 32. (652 aa)
F1SER8_PIGANK_REP_REGION domain-containing protein. (697 aa)
F1SER7_PIGANK_REP_REGION domain-containing protein. (858 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
ADIGAdipogenin; Plays a role in stimulating adipocyte differentiation and development; Belongs to the adipogenin family. (81 aa)
PLAC8Uncharacterized protein. (161 aa)
EBF2EBF transcription factor 2. (575 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
GDF10Growth differentiation factor 10. (480 aa)
FFAR4Free fatty acid receptor 4 isoform GPR120-S. (361 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (516 aa)
CTBP2C-terminal binding protein 2. (982 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
STEAP4Metalloreductase STEAP4. (470 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform b. (319 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa)
ALOXE3Arachidonate lipoxygenase 3. (710 aa)
EP300E1A binding protein p300. (2420 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (774 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CLIP3CAP-Gly domain-containing linker protein 3. (547 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (727 aa)
SH2B2SH2B adaptor protein 2. (695 aa)
RETREG1Reticulophagy regulator 1. (565 aa)
JDP2Jun dimerization protein 2. (268 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ARL4CUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (192 aa)
SOX8SRY-box transcription factor 8. (460 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
A0A286ZVA3_PIGCCDC144C domain-containing protein. (323 aa)
BBS1Bardet-Biedl syndrome 1 protein. (593 aa)
FABP4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
RGS2Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] (212 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
SDF4Stromal cell derived factor 4. (478 aa)
PSMB8Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adip [...] (295 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
ANGPTL8Angiopoietin-like protein 8. (198 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (428 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (596 aa)
YME1L1ANK_REP_REGION domain-containing protein. (2031 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (426 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
DIO2Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa)
ADIPOQC1q domain-containing protein. (332 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ZNF423Zinc finger protein 423 isoform X2. (1292 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (552 aa)
A0A287B396_PIGWAP domain-containing protein. (73 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
A0A287B8V2_PIGWAP domain-containing protein. (73 aa)
RNASEL2-5A-dependent ribonuclease. (743 aa)
CNTN2Contactin 2. (1038 aa)
NIPBLNipped-B protein. (2804 aa)
FAM120BFamily with sequence similarity 120B. (934 aa)
TTC8Tetratricopeptide repeat domain 8. (587 aa)
ZNF516Zinc finger protein 516. (1138 aa)
GDF6Growth/differentiation factor 6 preproprotein. (459 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (407 aa)
PRLHProlactin releasing hormone. (87 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
HMGA2Uncharacterized protein. (143 aa)
NUDT7Nudix hydrolase 7. (237 aa)
BBS4Uncharacterized protein. (826 aa)
ARL4AADP-ribosylation factor-like protein 4A. (200 aa)
TMEM120ATransmembrane protein 120A isoform 1. (312 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (956 aa)
PIAS1Protein inhibitor of activated STAT 1. (685 aa)
FBXO9F-box domain-containing protein. (448 aa)
BBS12Bardet-Biedl syndrome 12. (714 aa)
ARID5BAT-rich interaction domain 5B. (1194 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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