STRINGSTRING
TJP1 TJP1 MET MET MARVELD2 MARVELD2 HOXB5 HOXB5 RAPGEF3 RAPGEF3 FASN FASN VEZF1 VEZF1 PTPRS PTPRS RAP2C RAP2C I3LLG5_PIG I3LLG5_PIG PDE2A PDE2A DLL1 DLL1 HOXA13 HOXA13 KDR KDR COL18A1 COL18A1 TJP3 TJP3 CLIC4 CLIC4 FZD2 FZD2 MSN MSN PECAM1 PECAM1 F2RL1 F2RL1 SOX18 SOX18 NOTCH1 NOTCH1 RAP1A RAP1A PROX1 PROX1 TJP2 TJP2 KDM6B KDM6B FSTL1 FSTL1 A0A5G2QF80_PIG A0A5G2QF80_PIG PLOD3 PLOD3 CCM2 CCM2 TMEM100 TMEM100 ACVR2B ACVR2B DMD DMD MYADM MYADM RAPGEF2 RAPGEF2 F11R F11R BMPR2 BMPR2 VHL VHL MYD88 MYD88 EDNRB EDNRB HPSE HPSE EDNRA EDNRA BARX1 BARX1 PPP1R16B PPP1R16B HAPLN2 HAPLN2 SOX17 SOX17 COL22A1 COL22A1 COL15A1 COL15A1 SMAD4 SMAD4 HEY2 HEY2 EZR EZR TIE1 TIE1 NR2F2 NR2F2 MESP1 MESP1 F1RMG9_PIG F1RMG9_PIG ACVRL1 ACVRL1 ROBO4 ROBO4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1862 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
MARVELD2MARVEL domain-containing protein 2 isoform 1. (559 aa)
HOXB5Homeobox protein Hox-B5. (269 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform a. (923 aa)
FASNUncharacterized protein. (1430 aa)
VEZF1Vascular endothelial zinc finger 1. (526 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1946 aa)
RAP2CRAP2C, member of RAS oncogene family. (183 aa)
I3LLG5_PIGUncharacterized protein. (131 aa)
PDE2APhosphodiesterase. (1010 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
HOXA13Homeobox A13. (388 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
COL18A1Collagen type XVIII alpha 1 chain. (1755 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (1024 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
MSNMoesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation. (612 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
F2RL1Proteinase-activated receptor 2 preproprotein. (397 aa)
SOX18SRY-box transcription factor 18. (389 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PROX1Prospero homeobox 1. (737 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1187 aa)
KDM6BLysine demethylase 6B. (1638 aa)
FSTL1Follistatin like 1. (307 aa)
A0A5G2QF80_PIGUncharacterized protein. (287 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa)
CCM2CCM2 scaffold protein. (537 aa)
TMEM100Transmembrane protein 100 isoform X1. (134 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
DMDDystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3679 aa)
MYADMMyeloid associated differentiation marker. (391 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1662 aa)
F11RUncharacterized protein. (347 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (205 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
HPSEHeparanase isoform 1 preproprotein. (551 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
BARX1Homeobox protein BarH-like 1. (254 aa)
PPP1R16BProtein phosphatase 1 regulatory inhibitor subunit 16B isoform X1. (568 aa)
HAPLN2Hyaluronan and proteoglycan link protein 2. (340 aa)
SOX17SRY-box transcription factor 17. (407 aa)
COL22A1Collagen type XXII alpha 1 chain. (1602 aa)
COL15A1Collagen type XV alpha 1 chain. (1359 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
EZREzrin. (562 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
F1RMG9_PIGUncharacterized protein. (298 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
ROBO4Roundabout guidance receptor 4. (1010 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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