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ZBTB16 ZBTB16 RARA RARA A0A286ZWW0_PIG A0A286ZWW0_PIG IFNG IFNG RHOH RHOH IL23A IL23A PTPRC PTPRC GATA3 GATA3 BAD BAD RHOA RHOA XBP1 XBP1 FOXP3 FOXP3 CD74 CD74 EGR3 EGR3 ITPKB ITPKB ZBTB7B ZBTB7B SOX13 SOX13 CD83 CD83 IL7 IL7 A0A5G2QKY7_PIG A0A5G2QKY7_PIG KAT5 KAT5 NCKAP1L NCKAP1L MYB MYB SLA-DQA1 SLA-DQA1 ADA ADA NFKBIZ NFKBIZ CBFB CBFB NKAP NKAP HLX HLX PIK3R6 PIK3R6 SOCS5 SOCS5 ZBTB1 ZBTB1 SOCS1 SOCS1 TNFSF9 TNFSF9 IL1RL2 IL1RL2 STAT5B STAT5B GLI3 GLI3 SHH SHH IHH IHH IL4 IL4 AP3B1 AP3B1 AMBRA1 AMBRA1 SART1 SART1 SASH3 SASH3 VSIG1 VSIG1 BCL6 BCL6 CCL19 CCL19 DUSP10 DUSP10 ZMIZ1 ZMIZ1 VSIR VSIR SHB SHB ANXA1 ANXA1 RASGRP1 RASGRP1 FOXO3 FOXO3 VNN1 VNN1 IL4I1 IL4I1 CD27 CD27 WNT10B WNT10B PRKCZ PRKCZ RIPK2 RIPK2 IL7R IL7R PCK1 PCK1 ADAM8 ADAM8 MALT1 MALT1 TGFB1 TGFB1 ZAP70 ZAP70 SYK SYK LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
A0A286ZWW0_PIGAIG1-type G domain-containing protein. (321 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (193 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
BADBCL2 associated agonist of cell death. (209 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
XBP1BZIP domain-containing protein. (378 aa)
FOXP3Forkhead box protein P3 isoform a. (475 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B isoform X1. (543 aa)
SOX13SRY-box transcription factor 13. (676 aa)
CD83Ig-like domain-containing protein. (365 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa)
A0A5G2QKY7_PIGKinase; Belongs to the inositol phosphokinase (IPK) family. (363 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
MYBMYB proto-oncogene, transcription factor. (744 aa)
SLA-DQA1SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa)
ADAAdenosine deaminase. (409 aa)
NFKBIZNFKB inhibitor zeta. (747 aa)
CBFBCore-binding factor subunit beta. (204 aa)
NKAPNFKB activating protein. (431 aa)
HLXH2.0 like homeobox. (556 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (942 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (259 aa)
IL1RL2Interleukin 1 receptor like 2. (644 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
GLI3GLI family zinc finger 3. (1586 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (803 aa)
SASH3SAM and SH3 domain containing 3. (420 aa)
VSIG1Uncharacterized protein. (1377 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
CCL19C-C motif chemokine. (100 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1065 aa)
VSIRV-set immunoregulatory receptor. (310 aa)
SHBSH2 domain-containing protein. (507 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
FOXO3Forkhead box protein O3 isoform X1. (672 aa)
VNN1Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. (512 aa)
IL4I1Amine oxidase. (578 aa)
CD27CD27. (249 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
IL7RFibronectin type-III domain-containing protein. (458 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ZAP70Tyrosine-protein kinase. (615 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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