STRINGSTRING
F1RW79_PIG F1RW79_PIG PIM1 PIM1 SIX1 SIX1 ADIG ADIG BMP7 BMP7 SFRP2 SFRP2 MEDAG MEDAG FFAR4 FFAR4 PPARG PPARG TFE3 TFE3 LRP5 LRP5 ZFP36 ZFP36 FNDC5 FNDC5 NOCT NOCT ZBTB7C ZBTB7C SFRP1 SFRP1 WIF1 WIF1 SAV1 SAV1 HTR2A HTR2A ZBTB16 ZBTB16 DKKL1 DKKL1 PTGS2 PTGS2 HNRNPU HNRNPU SULT1E1 SULT1E1 CREB1 CREB1 AAMDC AAMDC CDS1 CDS1 BMP2 BMP2 ADIRF ADIRF FRZB FRZB FNDC3B FNDC3B KLF5 KLF5 CEBPB CEBPB STK3 STK3 SYAP1 SYAP1 XBP1 XBP1 CREBL2 CREBL2 NAPEPLD NAPEPLD RARRES2 RARRES2 ZNF385A ZNF385A ZC3H12A ZC3H12A A0A287BKN3_PIG A0A287BKN3_PIG CMKLR1 CMKLR1 ZBTB7B ZBTB7B SOX13 SOX13 ZFP36L1 ZFP36L1 WDFY2 WDFY2 ASXL2 ASXL2 VSTM2A VSTM2A CCDC71L CCDC71L STK4 STK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F1RW79_PIGUncharacterized protein. (708 aa)
PIM1Pim-1 proto-oncogene, serine/threonine kinase. (518 aa)
SIX1Six homeobox 1. (284 aa)
ADIGAdipogenin; Plays a role in stimulating adipocyte differentiation and development; Belongs to the adipogenin family. (81 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
SFRP2Uncharacterized protein. (294 aa)
MEDAGMesenteric estrogen dependent adipogenesis. (303 aa)
FFAR4Free fatty acid receptor 4 isoform GPR120-S. (361 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
ZFP36Uncharacterized protein. (372 aa)
FNDC5Fibronectin type III domain containing 5. (250 aa)
NOCTNocturnin. (427 aa)
ZBTB7CZinc finger and BTB domain-containing protein 7C isoform X2. (619 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
SAV1Salvador family WW domain containing protein 1. (433 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
DKKL1Dickkopf-like protein 1 isoform X2. (233 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
SULT1E1Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
AAMDCUncharacterized protein. (122 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (472 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
ADIRFUncharacterized protein. (75 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
FNDC3BFibronectin type III domain containing 3B. (1178 aa)
KLF5Uncharacterized protein. (457 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
STK3Serine/threonine kinase 3. (542 aa)
SYAP1Synapse-associated protein 1. (358 aa)
XBP1BZIP domain-containing protein. (378 aa)
CREBL2cAMP-responsive element-binding protein-like 2. (120 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (426 aa)
RARRES2Retinoic acid receptor responder 2. (177 aa)
ZNF385AZinc finger protein 385A. (406 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
A0A287BKN3_PIGUncharacterized protein. (95 aa)
CMKLR1Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). (363 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B isoform X1. (543 aa)
SOX13SRY-box transcription factor 13. (676 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
WDFY2WD repeat and FYVE domain containing 2. (451 aa)
ASXL2ASXL transcriptional regulator 2. (1544 aa)
VSTM2AV-set and transmembrane domain containing 2A. (253 aa)
CCDC71LUncharacterized protein. (307 aa)
STK4Serine/threonine kinase 4. (502 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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