(43 nodes) Regulation of epidermal cell differentiation network (Sus scrofa)

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second shell of interactors

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Your Input:
	VDR	Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
	KRT84	Keratin 84; Belongs to the intermediate filament family. (593 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	PRKCH	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
	NCOA3	Uncharacterized protein. (1296 aa)
	ATOH1	Atonal bHLH transcription factor 1. (353 aa)
	ZBED2	Zinc finger BED domain-containing protein 2. (217 aa)
	ETV4	ETS variant 4. (485 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (718 aa)
	SGPP1	Sphingosine-1-phosphate phosphatase 1. (443 aa)
	MAFF	MAF bZIP transcription factor F. (166 aa)
	HOXA7	Homeobox A7. (234 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
	ZFP36	Uncharacterized protein. (372 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
	PTCH1	Protein patched homolog 1 isoform L. (1452 aa)
	CD109	CD109 antigen isoform 1 preproprotein. (1449 aa)
	SFRP4	Secreted frizzled-related protein 4. (346 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (461 aa)
	PTCH2	Patched 2. (1207 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	HES1	Uncharacterized protein. (280 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
	MAFG	MAF bZIP transcription factor G. (162 aa)
	HES5	Hes family bHLH transcription factor 5. (226 aa)
	MYCL	MYCL proto-oncogene, bHLH transcription factor. (364 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
	KEAP1	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2134 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2593 aa)
	TRIM16	Uncharacterized protein. (582 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (348 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	KLF7	Kruppel like factor 7. (302 aa)
	KRT36	Keratin 36; Belongs to the intermediate filament family. (459 aa)
	GRHL2	Grainyhead like transcription factor 2. (626 aa)
	GRHL1	Grainyhead like transcription factor 1. (649 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	DLL1	ENSSSCP00000009805	ENSSSCP00000025758	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.624
ATOH1	HES1	ENSSSCP00000009805	ENSSSCP00000047613	Atonal bHLH transcription factor 1.	Uncharacterized protein.	0.485
ATOH1	HES5	ENSSSCP00000009805	ENSSSCP00000053835	Atonal bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.589
ATOH1	NOTCH1	ENSSSCP00000009805	ENSSSCP00000050060	Atonal bHLH transcription factor 1.	Neurogenic locus notch homolog protein 1 preproprotein.	0.601
ATOH1	PTCH1	ENSSSCP00000009805	ENSSSCP00000028104	Atonal bHLH transcription factor 1.	Protein patched homolog 1 isoform L.	0.527
BMP4	FGF2	ENSSSCP00000005423	ENSSSCP00000055271	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.875
BMP4	NOTCH1	ENSSSCP00000005423	ENSSSCP00000050060	Bone morphogenetic protein 4.	Neurogenic locus notch homolog protein 1 preproprotein.	0.461
BMP4	PTCH1	ENSSSCP00000005423	ENSSSCP00000028104	Bone morphogenetic protein 4.	Protein patched homolog 1 isoform L.	0.575
CYP27B1	MED1	ENSSSCP00000022818	ENSSSCP00000018552	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.577
CYP27B1	NCOA3	ENSSSCP00000022818	ENSSSCP00000007946	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.474
CYP27B1	VDR	ENSSSCP00000022818	ENSSSCP00000055650	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity).	0.887
DLL1	ATOH1	ENSSSCP00000025758	ENSSSCP00000009805	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Atonal bHLH transcription factor 1.	0.624
DLL1	HES1	ENSSSCP00000025758	ENSSSCP00000047613	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.591
DLL1	HES5	ENSSSCP00000025758	ENSSSCP00000053835	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.699
DLL1	HEY2	ENSSSCP00000025758	ENSSSCP00000004561	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 2.	0.623
DLL1	NOTCH1	ENSSSCP00000025758	ENSSSCP00000050060	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1 preproprotein.	0.995
ETV4	NCOA3	ENSSSCP00000018413	ENSSSCP00000007946	ETS variant 4.	Uncharacterized protein.	0.919
EZH2	NOTCH1	ENSSSCP00000048035	ENSSSCP00000050060	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Neurogenic locus notch homolog protein 1 preproprotein.	0.474
FGF2	BMP4	ENSSSCP00000055271	ENSSSCP00000005423	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.875
FGF2	NOTCH1	ENSSSCP00000055271	ENSSSCP00000050060	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neurogenic locus notch homolog protein 1 preproprotein.	0.519