STRINGSTRING
RIPOR2 RIPOR2 PPARD PPARD CMTM5 CMTM5 AKIRIN1 AKIRIN1 BMP4 BMP4 LRRC8A LRRC8A SMYD1 SMYD1 TBX3 TBX3 MYOD1 MYOD1 MEF2C MEF2C CXCL14 CXCL14 MSTN MSTN RANBP3L RANBP3L SOX9 SOX9 CDON CDON XKR8 XKR8 DLL1 DLL1 MBNL3 MBNL3 TGFB1 TGFB1 NMRK2 NMRK2 CXCL10 CXCL10 MAP3K5 MAP3K5 SOX8 SOX8 TRIP4 TRIP4 PRICKLE1 PRICKLE1 KLHL41 KLHL41 DDIT3 DDIT3 FLOT2 FLOT2 CXCL9 CXCL9 MYOG MYOG NOTCH1 NOTCH1 HIF1AN HIF1AN ID3 ID3 TMEM182 TMEM182 ZFP36L1 ZFP36L1 KAT5 KAT5 MYF5 MYF5 TNFSF14 TNFSF14 SOSTDC1 SOSTDC1 MYOCD MYOCD BOC BOC MYF6 MYF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPOR2PL48 domain-containing protein. (1063 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
CMTM5MARVEL domain-containing protein. (229 aa)
AKIRIN1Uncharacterized protein. (226 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
SMYD1SET and MYND domain containing 1. (539 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
CXCL14SCY domain-containing protein. (110 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
RANBP3LRAN binding protein 3 like. (485 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
XKR8XK-related protein. (495 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
MBNL3Muscleblind like splicing regulator 3. (369 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NMRK2Nicotinamide riboside kinase 2 isoform 2. (195 aa)
CXCL10C-X-C motif chemokine. (104 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1425 aa)
SOX8SRY-box transcription factor 8. (460 aa)
TRIP4Thyroid hormone receptor interactor 4. (649 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
KLHL41Kelch like family member 41. (601 aa)
DDIT3DNA-damage-inducible transcript 3. (167 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
CXCL9C-X-C motif chemokine. (126 aa)
MYOGMyogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (215 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (361 aa)
ID3BHLH domain-containing protein. (118 aa)
TMEM182Transmembrane protein 182 isoform a. (229 aa)
ZFP36L1ZFP36 ring finger protein like 1. (348 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
SOSTDC1Sclerostin domain containing 1. (229 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1241 aa)
MYF6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (249 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.