(54 nodes) Positive regulation of neuron differentiation network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BEND6	BEN domain-containing protein 6 isoform X1. (279 aa)
	IRX3	Iroquois-class homeodomain protein IRX-3 isoform X2. (502 aa)
	DUOXA1	Dual oxidase maturation factor 1. (337 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TRIM32	Tripartite motif containing 32. (652 aa)
	BRINP1	BMP/retinoic acid-inducible neural-specific protein 1 isoform X1. (761 aa)
	BMP7	Bone morphogenetic protein 7. (650 aa)
	MMD2	Uncharacterized protein. (578 aa)
	ADRA2B	Alpha-2B adrenergic receptor. (446 aa)
	SOX11	Transcription factor SOX. (447 aa)
	ATOH1	Atonal bHLH transcription factor 1. (353 aa)
	NKX6-1	NK6 homeobox 1. (370 aa)
	FEZF2	FEZ family zinc finger 2. (503 aa)
	BCL6	B-cell lymphoma 6 protein isoform X1. (706 aa)
	MEF2C	Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
	NEUROG1	Neurogenin 1. (246 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	HOXD3	Homeobox protein Hox-D3. (432 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	MMD	Monocyte to macrophage differentiation associated. (274 aa)
	GDF7	Growth differentiation factor 7. (449 aa)
	ADRA2C	Adrenoceptor alpha 2C. (460 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1247 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1128 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	PCP4	Purkinje cell protein 4. (62 aa)
	ECT2	Epithelial cell transforming 2. (1028 aa)
	SPAG9	Sperm associated antigen 9. (1338 aa)
	GDPD5	Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1. (610 aa)
	ARHGEF2	Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] (1066 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
	DLX1	Homeobox protein DLX-1 isoform 1. (255 aa)
	BMP2	Bone morphogenetic protein 2 preproprotein. (395 aa)
	NEUROD2	Neurogenic differentiation factor. (382 aa)
	FOXG1	Forkhead box G1. (486 aa)
	BRINP2	BMP/retinoic acid inducible neural specific 2. (787 aa)
	SIN3A	SIN3 transcription regulator family member A. (1274 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	BRINP3	BMP/retinoic acid inducible neural specific 3. (766 aa)
	FOXA1	Forkhead box A1. (468 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	RNF112	Ring finger protein 112. (628 aa)
	CYB5D2	Cytochrome b5 domain containing 2; Belongs to the cytochrome b5 family. (264 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1613 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (273 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
	BMP6	TGF_BETA_2 domain-containing protein. (537 aa)
	VWC2	Von Willebrand factor C domain containing 2. (325 aa)
	FEZF1	FEZ family zinc finger 1. (475 aa)
	PHOX2B	Paired like homeobox 2B. (314 aa)
	VWC2L	Von Willebrand factor C domain-containing protein 2-like isoform 1. (222 aa)
	ZC4H2	Zinc finger C4H2-type containing. (272 aa)
	REST	RE1 silencing transcription factor. (1108 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2B	ADRA2C	ENSSSCP00000008672	ENSSSCP00000022833	Alpha-2B adrenergic receptor.	Adrenoceptor alpha 2C.	0.503
ADRA2C	ADRA2B	ENSSSCP00000022833	ENSSSCP00000008672	Adrenoceptor alpha 2C.	Alpha-2B adrenergic receptor.	0.503
ARHGEF2	RHOA	ENSSSCP00000034411	ENSSSCP00000045785	Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...]	Transforming protein RhoA isoform 1.	0.976
ATOH1	FOXG1	ENSSSCP00000009805	ENSSSCP00000037951	Atonal bHLH transcription factor 1.	Forkhead box G1.	0.603
ATOH1	HEYL	ENSSSCP00000009805	ENSSSCP00000034814	Atonal bHLH transcription factor 1.	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1.	0.484
ATOH1	PHOX2B	ENSSSCP00000009805	ENSSSCP00000059179	Atonal bHLH transcription factor 1.	Paired like homeobox 2B.	0.580
BCL6	MMD	ENSSSCP00000012581	ENSSSCP00000018659	B-cell lymphoma 6 protein isoform X1.	Monocyte to macrophage differentiation associated.	0.406
BCL6	SIN3A	ENSSSCP00000012581	ENSSSCP00000040790	B-cell lymphoma 6 protein isoform X1.	SIN3 transcription regulator family member A.	0.591
BMP2	BMP4	ENSSSCP00000037008	ENSSSCP00000005423	Bone morphogenetic protein 2 preproprotein.	Bone morphogenetic protein 4.	0.907
BMP2	BMP6	ENSSSCP00000037008	ENSSSCP00000055803	Bone morphogenetic protein 2 preproprotein.	TGF_BETA_2 domain-containing protein.	0.477
BMP2	BMP7	ENSSSCP00000037008	ENSSSCP00000007993	Bone morphogenetic protein 2 preproprotein.	Bone morphogenetic protein 7.	0.720
BMP2	FGF2	ENSSSCP00000037008	ENSSSCP00000055271	Bone morphogenetic protein 2 preproprotein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.819
BMP4	BMP2	ENSSSCP00000005423	ENSSSCP00000037008	Bone morphogenetic protein 4.	Bone morphogenetic protein 2 preproprotein.	0.907
BMP4	BMP6	ENSSSCP00000005423	ENSSSCP00000055803	Bone morphogenetic protein 4.	TGF_BETA_2 domain-containing protein.	0.554
BMP4	BMP7	ENSSSCP00000005423	ENSSSCP00000007993	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.842
BMP4	DLX2	ENSSSCP00000005423	ENSSSCP00000016906	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.454
BMP4	FGF2	ENSSSCP00000005423	ENSSSCP00000055271	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.875
BMP4	FGFR1	ENSSSCP00000005423	ENSSSCP00000030160	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.506
BMP4	MEF2C	ENSSSCP00000005423	ENSSSCP00000015044	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...]	0.463
BMP4	NKX2-5	ENSSSCP00000005423	ENSSSCP00000041789	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.469