STRINGSTRING
HAND2 HAND2 GLI1 GLI1 ATF4 ATF4 SMOC1 SMOC1 FERMT2 FERMT2 TP63 TP63 FBN2 FBN2 CCN1 CCN1 ACVR2B ACVR2B TWSG1 TWSG1 RUNX2 RUNX2 BMPR2 BMPR2 RORB RORB REST REST SMAD3 SMAD3 HDAC4 HDAC4 HDAC7 HDAC7 ATRAID ATRAID ILK ILK I3L7W9_PIG I3L7W9_PIG TNFAIP6 TNFAIP6 SOX9 SOX9 RANBP3L RANBP3L GLI3 GLI3 HOXA2 HOXA2 VEGFC VEGFC SUCO SUCO SCUBE2 SCUBE2 MEF2C MEF2C MEN1 MEN1 TCIRG1 TCIRG1 LRP5 LRP5 WWTR1 WWTR1 LIMD1 LIMD1 BAMBI BAMBI FFAR4 FFAR4 GDF10 GDF10 PPP3CA PPP3CA SFRP2 SFRP2 SOX11 SOX11 CRIM1 CRIM1 BMP7 BMP7 JAG1 JAG1 DDR2 DDR2 CTHRC1 CTHRC1 BMP4 BMP4 SMAD6 SMAD6 TENT5A TENT5A FBXO5 FBXO5 PRKD1 PRKD1 WNT10B WNT10B IL6 IL6 BMPR1B BMPR1B IGFBP5 IGFBP5 NOCT NOCT LTF LTF LRP3 LRP3 PTCH1 PTCH1 GDPD2 GDPD2 GNAS GNAS SFRP1 SFRP1 SEMA4D SEMA4D CDK6 CDK6 IL6ST IL6ST TRMO TRMO CTNNB1 CTNNB1 SMAD1 SMAD1 SMAD5 SMAD5 YAP1 YAP1 WDR63 WDR63 PRKACA PRKACA BMP2 BMP2 SNAI2 SNAI2 GREM1 GREM1 ACVR2A ACVR2A RIOX1 RIOX1 OSTN OSTN UCMA UCMA BMPR1A BMPR1A SCUBE3 SCUBE3 CTNNBIP1 CTNNBIP1 SKI SKI ZHX3 ZHX3 NBR1 NBR1 FNDC3B FNDC3B CEBPB CEBPB FGF23 FGF23 CCN4 CCN4 NOTCH1 NOTCH1 RASSF2 RASSF2 CHRD CHRD ID3 ID3 NOG NOG PDLIM7 PDLIM7 AXIN2 AXIN2 FGF2 FGF2 TNN TNN BMP6 BMP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
ATF4Activating transcription factor 4. (329 aa)
SMOC1SPARC related modular calcium binding 1. (469 aa)
FERMT2Fermitin family member 2. (776 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FBN2Fibrillin 2. (2910 aa)
CCN1Cellular communication network factor 1. (382 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (291 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
RORBRAR related orphan receptor B. (548 aa)
RESTRE1 silencing transcription factor. (1108 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (980 aa)
ATRAIDUncharacterized protein. (236 aa)
ILKIntegrin linked kinase. (479 aa)
I3L7W9_PIGUncharacterized protein. (373 aa)
TNFAIP6Uncharacterized protein. (277 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
RANBP3LRAN binding protein 3 like. (485 aa)
GLI3GLI family zinc finger 3. (1586 aa)
HOXA2Homeobox protein Hox-A2. (380 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SUCOSUN domain containing ossification factor. (1222 aa)
SCUBE2CUB domain-containing protein. (539 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
MEN1Menin 1. (704 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
WWTR1WW domain containing transcription regulator 1. (398 aa)
LIMD1LIM domain-containing protein 1. (671 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FFAR4Free fatty acid receptor 4 isoform GPR120-S. (361 aa)
GDF10Growth differentiation factor 10. (480 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
SFRP2Uncharacterized protein. (294 aa)
SOX11Transcription factor SOX. (447 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1031 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (866 aa)
CTHRC1Collagen triple helix repeat containing 1. (244 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
TENT5ATerminal nucleotidyltransferase 5A. (434 aa)
FBXO5F-box protein 5. (462 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IGFBP5Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (271 aa)
NOCTNocturnin. (427 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa)
LRP3LDL receptor related protein 3. (759 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (569 aa)
GNASGuanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
TRMOTsaA-like domain-containing protein. (724 aa)
CTNNB1Catenin beta 1. (808 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
YAP1Yes associated protein 1. (432 aa)
WDR63WD repeat domain 63. (904 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (667 aa)
OSTNMusclin. (132 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (166 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1008 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
SKISKI proto-oncogene. (728 aa)
ZHX3Zinc fingers and homeoboxes protein 3 isoform X3. (954 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (960 aa)
FNDC3BFibronectin type III domain containing 3B. (1178 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
CCN4WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
RASSF2Ras association domain-containing protein 2 isoform X2. (326 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (1028 aa)
ID3BHLH domain-containing protein. (118 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PDLIM7PDZ and LIM domain 7. (515 aa)
AXIN2Axin-2. (843 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
TNNTenascin N. (1472 aa)
BMP6TGF_BETA_2 domain-containing protein. (537 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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