STRINGSTRING
NKX6-1 NKX6-1 EGR2 EGR2 CLCF1 CLCF1 SHH SHH HDAC1 HDAC1 TGFB1 TGFB1 IL6ST IL6ST OLIG2 OLIG2 LIF LIF BMP2 BMP2 IL34 IL34 PTN PTN ASPA ASPA RNF112 RNF112 ZNF488 ZNF488 HES1 HES1 BIN1 BIN1 SERPINE2 SERPINE2 NOTCH1 NOTCH1 NKX2-2 NKX2-2 NKX6-2 NKX6-2 TNFRSF1B TNFRSF1B MTOR MTOR GSX2 GSX2 ZNF365 ZNF365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX6-1NK6 homeobox 1. (370 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
CLCF1Uncharacterized protein. (484 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
IL34Interleukin 34. (243 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
ASPAAspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). (380 aa)
RNF112Ring finger protein 112. (628 aa)
ZNF488Zinc finger protein 488. (323 aa)
HES1Uncharacterized protein. (280 aa)
BIN1Bridging integrator 1. (588 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
NKX6-2Homeobox protein Nkx-6.2. (277 aa)
TNFRSF1BTNF receptor superfamily member 1B. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
GSX2GS homeobox 2. (304 aa)
ZNF365Zinc finger protein 365. (407 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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