STRINGSTRING
RUVBL2 RUVBL2 A0A5G2RGJ5_PIG A0A5G2RGJ5_PIG RNF168 RNF168 BCL7C BCL7C SHLD1 SHLD1 ENSSSCP00000073725 ENSSSCP00000073725 A0A5G2RES6_PIG A0A5G2RES6_PIG MFSD11 MFSD11 ERCC8 ERCC8 NFRKB NFRKB A0A5G2R4M1_PIG A0A5G2R4M1_PIG A0A5G2QVU0_PIG A0A5G2QVU0_PIG A0A5G2R3D3_PIG A0A5G2R3D3_PIG WDR48 WDR48 EGFR EGFR BRCC3 BRCC3 PNKP PNKP BCL7A BCL7A A0A5G2QSK7_PIG A0A5G2QSK7_PIG KAT5 KAT5 A0A5G2R3X2_PIG A0A5G2R3X2_PIG UBE2V2 UBE2V2 RPS3 RPS3 KMT5C KMT5C A0A287BQB1_PIG A0A287BQB1_PIG KMT5B KMT5B MGMT MGMT ZCWPW1 ZCWPW1 SLF2 SLF2 BABAM2 BABAM2 PARP9 PARP9 VPS72 VPS72 WAS WAS DMAP1 DMAP1 CCDC117 CCDC117 SPIDR SPIDR INO80D INO80D FH FH SELENOK SELENOK EYA4 EYA4 TMEM161A TMEM161A FAM168A FAM168A FOXM1 FOXM1 A0A287AFM3_PIG A0A287AFM3_PIG CEBPG CEBPG PCNA PCNA PIAS4 PIAS4 SPIRE1 SPIRE1 ING3 ING3 MEAF6 MEAF6 ARID2 ARID2 EYA1 EYA1 YEATS4 YEATS4 INO80E INO80E A0A286ZVL9_PIG A0A286ZVL9_PIG EPC1 EPC1 ACTB ACTB XRCC1 XRCC1 TRIM28 TRIM28 BRCA1 BRCA1 BABAM1 BABAM1 RAD51AP1 RAD51AP1 RBBP8 RBBP8 SHLD2 SHLD2 EYA2 EYA2 YY1 YY1 FUS FUS DHX9 DHX9 FANCB FANCB DTX3L DTX3L UIMC1 UIMC1 MAD2L2 MAD2L2 HDAC10 HDAC10 PARP3 PARP3 PARP1 PARP1 BRD8 BRD8 TIGAR TIGAR EP400 EP400 RUVBL1 RUVBL1 SMCHD1 SMCHD1 WRAP53 WRAP53 MBTD1 MBTD1 FGF10 FGF10 RIF1 RIF1 EPC2 EPC2 SLF1 SLF1 MRNIP MRNIP HDGFL2 HDGFL2 SIRT6 SIRT6 MORF4L2 MORF4L2 ACTL6A ACTL6A ACTR8 ACTR8 UCHL5 UCHL5 MMS19 MMS19 ERCC6 ERCC6 SIRT1 SIRT1 HELQ HELQ ABRAXAS1 ABRAXAS1 FAM178B FAM178B NPAS2 NPAS2 BCL7B BCL7B POGZ POGZ PRKDC PRKDC INO80 INO80 OOEP OOEP KHDC3L KHDC3L EYA3 EYA3 TFPT TFPT PRKCG PRKCG SPIRE2 SPIRE2 TIMELESS TIMELESS MCRS1 MCRS1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa)
A0A5G2RGJ5_PIGUncharacterized protein. (102 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (243 aa)
SHLD1Shieldin complex subunit 1. (276 aa)
ENSSSCP00000073725annotation not available (332 aa)
A0A5G2RES6_PIGReverse transcriptase domain-containing protein. (356 aa)
MFSD11Major facilitator superfamily domain containing 11. (491 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
NFRKBNuclear factor related to kappaB binding protein. (1333 aa)
A0A5G2R4M1_PIGReverse transcriptase domain-containing protein. (784 aa)
A0A5G2QVU0_PIGReverse transcriptase domain-containing protein. (742 aa)
A0A5G2R3D3_PIGReverse transcriptase domain-containing protein. (1014 aa)
WDR48WD repeat domain 48. (740 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (316 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (578 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (260 aa)
A0A5G2QSK7_PIGReverse transcriptase domain-containing protein. (680 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
A0A5G2R3X2_PIGReverse transcriptase domain-containing protein. (774 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa)
KMT5CLysine methyltransferase 5C. (455 aa)
A0A287BQB1_PIGzf-C3HC4 domain-containing protein. (282 aa)
KMT5BLysine methyltransferase 5B. (915 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (265 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (653 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1169 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (847 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog isoform 2. (364 aa)
WASWASP actin nucleation promoting factor. (500 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
CCDC117Coiled-coil domain containing 117. (279 aa)
SPIDRDNA repair-scaffolding protein isoform 1. (924 aa)
INO80DINO80 complex subunit D. (1028 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa)
SELENOKSelenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
FAM168AFamily with sequence similarity 168 member A. (234 aa)
FOXM1Forkhead box M1. (766 aa)
A0A287AFM3_PIGReverse transcriptase domain-containing protein. (831 aa)
CEBPGCCAAT enhancer binding protein gamma. (164 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
PIAS4Protein inhibitor of activated STAT 4. (566 aa)
SPIRE1Spire type actin nucleation factor 1. (802 aa)
ING3Inhibitor of growth protein. (418 aa)
MEAF6MYST/Esa1 associated factor 6. (216 aa)
ARID2AT-rich interaction domain 2. (1833 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
YEATS4YEATS domain containing 4. (227 aa)
INO80EINO80 complex subunit E isoform 1. (244 aa)
A0A286ZVL9_PIGRING-type domain-containing protein. (137 aa)
EPC1Enhancer of polycomb homolog. (841 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
XRCC1X-ray repair cross complementing 1. (617 aa)
TRIM28Tripartite motif containing 28. (868 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
RAD51AP1RAD51 associated protein 1. (345 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
SHLD2Shieldin complex subunit 2. (907 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa)
YY1YY1 transcription factor. (438 aa)
FUSFUS RNA binding protein. (518 aa)
DHX9ATP-dependent RNA helicase A. (1384 aa)
FANCBFA complementation group B. (855 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (737 aa)
UIMC1BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] (622 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
HDAC10Histone deacetylase 10. (671 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
BRD8Bromodomain containing 8. (1236 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
EP400E1A binding protein p400. (3210 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa)
WRAP53WD repeat containing antisense to TP53. (539 aa)
MBTD1Mbt domain containing 1. (715 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1055 aa)
MRNIPUncharacterized protein. (216 aa)
HDGFL2HDGF like 2. (667 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (327 aa)
MORF4L2Mortality factor 4 like 2. (288 aa)
ACTL6AActin-like protein 6A isoform X1; Belongs to the actin family. (429 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1039 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1462 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
HELQHelicase, POLQ like. (1076 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (405 aa)
FAM178BUncharacterized protein. (569 aa)
NPAS2Neuronal PAS domain protein 2. (796 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (249 aa)
POGZPogo transposable element with ZNF domain isoform X1. (1412 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa)
INO80INO80 complex ATPase subunit. (1566 aa)
OOEPOocyte-expressed protein homolog. (148 aa)
KHDC3LMOEP19 domain-containing protein. (142 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
TFPTTCF3 fusion partner isoform 1. (253 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
SPIRE2Spire type actin nucleation factor 2. (763 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
MCRS1Microspherule protein 1. (487 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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