STRINGSTRING
EXOSC6 EXOSC6 EXOSC3 EXOSC3 MSH2 MSH2 NSD2 NSD2 CLCF1 CLCF1 IL4 IL4 RIF1 RIF1 TBX21 TBX21 STAT6 STAT6 MAD2L2 MAD2L2 TFRC TFRC TGFB1 TGFB1 SHLD2 SHLD2 TNFSF13 TNFSF13 SHLD1 SHLD1 CD28 CD28 HMCES HMCES KMT5C KMT5C IL2 IL2 KMT5B KMT5B ATAD5 ATAD5 CD40 CD40 PTPRC PTPRC TP53BP1 TP53BP1 PAXIP1 PAXIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXOSC6Exosome component 6. (272 aa)
EXOSC3Exosome complex component RRP40 isoform 1. (275 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa)
CLCF1Uncharacterized protein. (484 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
TBX21Uncharacterized protein. (535 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SHLD2Shieldin complex subunit 2. (907 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa)
SHLD1Shieldin complex subunit 1. (276 aa)
CD28IGv domain-containing protein. (222 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (410 aa)
KMT5CLysine methyltransferase 5C. (455 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
KMT5BLysine methyltransferase 5B. (915 aa)
ATAD5ATPase family AAA domain containing 5. (1891 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
TP53BP1Tumor protein p53 binding protein 1. (1931 aa)
PAXIP1PAX interacting protein 1. (1030 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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