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| | CTSZ | Cathepsin Z; Belongs to the peptidase C1 family. (304 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | TMED10 | Transmembrane emp24 domain-containing protein 10. (219 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa) |
| | SERPINB12 | Serpin family B member 12; Belongs to the serpin family. (425 aa) |
| | LOC106504547 | SERPIN domain-containing protein; Belongs to the serpin family. (445 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (314 aa) |
| | APLP2 | Amyloid beta precursor like protein 2. (770 aa) |
| | SLPI | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance t [...] (170 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (514 aa) |
| | WFDC11 | WAP four-disulfide core domain 11. (90 aa) |
| | USP19 | Ubiquitin specific peptidase 19. (1364 aa) |
| | SPINK6 | Serine peptidase inhibitor, Kazal type 6. (80 aa) |
| | BST2 | Uncharacterized protein. (177 aa) |
| | SERPINA5 | Plasma serine protease inhibitor preproprotein; Belongs to the serpin family. (408 aa) |
| | CAMLG | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (300 aa) |
| | USP9X | Putative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa) |
| | NLE1 | Notchless homolog 1. (487 aa) |
| | PIH1D1 | PIH1 domain containing 1. (289 aa) |
| | RYBP | RING1 and YY1 binding protein. (273 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | WFDC10AL | WAP four-disulfide core domain protein 10A. (108 aa) |
| | SPINK14 | Serine peptidase inhibitor, Kazal type 14 (putative). (98 aa) |
| | STYX | Serine/threonine/tyrosine interacting protein. (206 aa) |
| | CSNK2A2 | Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa) |
| | C5 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. (1677 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (856 aa) |
| | PDCL3 | Phosducin-like protein 3. (240 aa) |
| | A0A287AKL9_PIG | WAP four-disulfide core domain protein 15B. (79 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1175 aa) |
| | LOC100621494 | SERPIN domain-containing protein; Belongs to the serpin family. (407 aa) |
| | TLK2 | Tousled like kinase 2. (766 aa) |
| | SERPINB13 | Serpin family B member 13; Belongs to the serpin family. (390 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa) |
| | KIF12 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (651 aa) |
| | PSME3IP1 | Family with sequence similarity 192 member A. (256 aa) |
| | PTPN3 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (910 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | CRYAB | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (237 aa) |
| | BIN1 | Bridging integrator 1. (588 aa) |
| | SPAI-2 | Sodium/potassium ATPase inhibitor SPAI-2; Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+). (187 aa) |
| | TFPI | Tissue factor pathway inhibitor. (303 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (171 aa) |
| | A0A287AXL0_PIG | Uncharacterized protein. (502 aa) |
| | GAS6 | Uncharacterized protein. (682 aa) |
| | PTI | BPTI/Kunitz inhibitor domain-containing protein. (247 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (378 aa) |
| | FHIT | Fragile histidine triad diadenosine triphosphatase. (150 aa) |
| | SERPINF1 | Serpin family F member 1; Belongs to the serpin family. (433 aa) |
| | MMP9 | Matrix metalloproteinase-9. (708 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (603 aa) |
| | CLN3 | Battenin. (414 aa) |
| | TIMP4 | TIMP metallopeptidase inhibitor 4. (224 aa) |
| | NOL3 | Nucleolar protein 3. (237 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (927 aa) |
| | A0A287B396_PIG | WAP domain-containing protein. (73 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1296 aa) |
| | LOC100512873 | Antileukoproteinase. (157 aa) |
| | PLAUR | Plasminogen activator, urokinase receptor. (330 aa) |
| | A0A287B8V2_PIG | WAP domain-containing protein. (73 aa) |
| | SERPINF2 | Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa) |
| | LAMTOR5 | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa) |
| | RFFL | Uncharacterized protein. (799 aa) |
| | CST3 | Cystatin C; Belongs to the cystatin family. (146 aa) |
| | AHSG | Alpha-2-HS-glycoprotein. (394 aa) |
| | SPINT1 | Serine peptidase inhibitor, Kunitz type 1. (531 aa) |
| | LOC100153783 | Ovalbumin isoform X1; Belongs to the serpin family. (385 aa) |
| | PI3 | Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis (By similarity). (167 aa) |
| | SPINK2 | Serine protease inhibitor Kazal-type 2 isoform 1. (85 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (797 aa) |
| | SPINT2 | Serine peptidase inhibitor, Kunitz type 2. (252 aa) |
| | COL28A1 | Collagen type XXVIII alpha 1 chain. (1236 aa) |
| | BIRC7 | RING-type domain-containing protein. (151 aa) |
| | SERPINB6 | SERPIN domain-containing protein; Belongs to the serpin family. (399 aa) |
| | ALAD | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (312 aa) |
| | SERPINA3-2 | SERPIN domain-containing protein; Belongs to the serpin family. (473 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (385 aa) |
| | LRP11 | LDL receptor related protein 11. (517 aa) |
| | PZP | Uncharacterized protein. (1416 aa) |
| | SERPINB9 | SERPIN domain-containing protein; Belongs to the serpin family. (495 aa) |
| | DDRGK1 | DDRGK domain-containing protein 1. (312 aa) |
| | SPINK1 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). (79 aa) |
| | HFE | Homeostatic iron regulator; Belongs to the MHC class I family. (395 aa) |
| | HDAC6 | Histone deacetylase 6. (1159 aa) |
| | GIPC2 | PDZ domain-containing protein GIPC2 isoform 1. (313 aa) |
| | SORL1 | Sortilin related receptor 1. (2213 aa) |
| | ITIH3 | Inter-alpha-trypsin inhibitor heavy chain 3. (907 aa) |
| | A0A287BQB3_PIG | Uncharacterized protein. (149 aa) |
| | WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa) |
| | CSTA | Cystatin-A8; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (103 aa) |
| | LOC110261265 | NTR domain-containing protein. (239 aa) |
| | ITIH4 | Inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. (976 aa) |
| | RNF34 | E3 ubiquitin-protein ligase RNF34 isoform 2. (383 aa) |
| | WFDC2 | WAP four-disulfide core domain protein 2; Broad range protease inhibitor. (123 aa) |
| | SERPINH1 | SERPIN domain-containing protein; Belongs to the serpin family. (418 aa) |
| | SPOCK1 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa) |
| | SERPINA4 | Serpin family A member 4; Belongs to the serpin family. (371 aa) |
| | MTM1 | Myotubularin isoform X3. (603 aa) |
| | FAM124A | Family with sequence similarity 124 member A. (591 aa) |
| | TMEM98 | Transmembrane protein 98. (226 aa) |
| | BAG5 | BAG family molecular chaperone regulator 5 isoform b. (447 aa) |
| | TNFAIP8 | TNF alpha induced protein 8. (212 aa) |
| | RPL11 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (192 aa) |
| | ANXA8 | Annexin. (354 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa) |
| | LOC100517145 | Uncharacterized protein. (1670 aa) |
| | C4A | Uncharacterized protein. (1758 aa) |
| | SERPINI1 | Serpin family I member 1; Belongs to the serpin family. (502 aa) |
| | SPINK13 | Kazal-like domain-containing protein. (173 aa) |
| | LOC100739218 | Uncharacterized protein. (143 aa) |
| | LOC100513415 | Uncharacterized protein. (449 aa) |
| | SPINK5 | Serine peptidase inhibitor, Kazal type 5. (1023 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1356 aa) |
| | RECK | Reversion-inducing cysteine-rich protein with Kazal motifs isoform 1. (971 aa) |
| | UBXN1 | UBX domain protein 1. (310 aa) |
| | TAF9 | Transcription initiation factor TFIID subunit 9. (265 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | RARRES1 | Retinoic acid receptor responder protein 1 isoform X1. (290 aa) |
| | GABARAPL2 | Uncharacterized protein. (187 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa) |
| | A0A5G2QLC1_PIG | Uncharacterized protein. (477 aa) |
| | LOC100158011 | BPTI/Kunitz inhibitor domain-containing protein. (128 aa) |
| | SGTA | Small glutamine rich tetratricopeptide repeat containing alpha. (394 aa) |
| | TNFSF14 | Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa) |
| | TRIM39 | E3 ubiquitin-protein ligase TRIM39 isoform 2. (488 aa) |
| | TIMP2 | Uncharacterized protein. (257 aa) |
| | SERPINC1 | SERPIN domain-containing protein; Belongs to the serpin family. (431 aa) |
| | C3H16orf96 | Uncharacterized protein. (928 aa) |
| | SPINK8 | Serine peptidase inhibitor, Kazal type 8 (putative). (95 aa) |
| | LOC100516119 | Cystatin domain-containing protein. (186 aa) |
| | KNG1 | Kininogen 1. (630 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | LOC110261633 | SERPIN domain-containing protein; Belongs to the serpin family. (388 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa) |
| | PAX2 | Paired box 2. (416 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (482 aa) |
| | AMBP | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. (364 aa) |
| | CD109 | CD109 antigen isoform 1 preproprotein. (1449 aa) |
| | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross- talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating [...] (1074 aa) |
| | NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (470 aa) |
| | OPHN1 | Oligophrenin 1. (808 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (744 aa) |
| | A0A5G2R112_PIG | BPTI/Kunitz inhibitor domain-containing protein. (84 aa) |
| | LRIG2 | Leucine rich repeats and immunoglobulin like domains 2. (1065 aa) |
| | BIRC7-2 | Uncharacterized protein. (428 aa) |
| | A0A5G2RMR0_PIG | WAP domain-containing protein. (128 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (405 aa) |
| | A0A5G2RGT7_PIG | Uncharacterized protein. (147 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | A2M | Alpha-2-macroglobulin. (1504 aa) |
| | A2ML1 | Alpha-2-macroglobulin like 1. (1457 aa) |
| | CD27 | CD27. (249 aa) |
| | LRRK2 | Uncharacterized protein. (2501 aa) |
| | SERPINB1 | Leukocyte elastase inhibitor; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a [...] (413 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | PI16 | SCP domain-containing protein; Belongs to the CRISP family. (460 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | PAPLN | Papilin, proteoglycan like sulfated glycoprotein. (961 aa) |
| | SERPINA6 | Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. (434 aa) |
| | SERPINA1 | Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin (By similarity). (420 aa) |
| | SERPINA12 | Serpin family A member 12; Belongs to the serpin family. (414 aa) |
| | SERPINA11 | Serpin family A member 11; Belongs to the serpin family. (514 aa) |
| | UABP-2 | Uteroferrin-associated basic protein 2. (420 aa) |
| | LOC106504545 | SERPIN domain-containing protein; Belongs to the serpin family. (417 aa) |
| | LOC396684 | SERPIN domain-containing protein; Belongs to the serpin family. (411 aa) |
| | N4BP1 | NEDD4-binding protein 1. (897 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (458 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | MICAL1 | Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1122 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | SERPINB8 | Serpin family B member 8; Belongs to the serpin family. (374 aa) |
| | SERPINB10 | SERPIN domain-containing protein; Belongs to the serpin family. (397 aa) |
| | SERPINB2 | Plasminogen activator inhibitor 2; Belongs to the serpin family. (440 aa) |
| | SERPINB7 | Serpin family B member 7; Belongs to the serpin family. (380 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1283 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (327 aa) |
| | PI15 | Peptidase inhibitor 15; Belongs to the CRISP family. (258 aa) |
| | EFNA1 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa) |
| | PLAT | Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa) |
| | CSTL1 | Cystatin like 1. (137 aa) |
| | CST11 | Cystatin 11. (137 aa) |
| | LOC100515765 | Cystatin domain-containing protein. (128 aa) |
| | CST8 | Cystatin domain-containing protein. (274 aa) |
| | CST7 | Cystatin domain-containing protein. (146 aa) |
| | AVP | Vasopressin-neurophysin 2-copeptin. (217 aa) |
| | R3HDML | R3H domain containing like. (252 aa) |
| | WFDC5 | WAP four-disulfide core domain 5. (166 aa) |
| | WFDC8 | WAP four-disulfide core domain 8. (252 aa) |
| | WFDC9 | WAP four-disulfide core domain 9. (88 aa) |
| | WFDC3 | WAP domain-containing protein. (94 aa) |
| | SPINK7 | Serine peptidase inhibitor, Kazal type 7 (putative). (85 aa) |
| | COL6A3 | Collagen type VI alpha 3 chain. (2911 aa) |
| | FAM124B | Family with sequence similarity 124 member B. (454 aa) |
| | USP25 | Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa) |
| | CST9L | Cystatin-9-like. (149 aa) |
| | UBE2Z | Ubiquitin-conjugating enzyme E2 Z. (356 aa) |
| | LTF | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa) |
| | SERPINE1 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa) |
| | UPTI | Uterine plasmin/trypsin inhibitor; Inhibitor of plasmin and trypsin. Also has a weak affinity for chymotrypsin. Could serve to neutralize the activities of one or more serine proteinases generated by the proliferating trophoblast during the formation of the noninvasive placenta. (103 aa) |
| | GLG1 | Golgi glycoprotein 1. (1210 aa) |
| | TTC36 | Tetratricopeptide repeat domain 36. (188 aa) |
| | LXN | Latexin. (222 aa) |
| | LOC100625207 | USP domain-containing protein; Belongs to the peptidase C19 family. (2554 aa) |
| | MARCHF7 | Membrane associated ring-CH-type finger 7. (708 aa) |
| | WFDC10A | WAP four-disulfide core domain 10A. (78 aa) |
| | SERPINB11 | Serpin family B member 11 (gene/pseudogene); Belongs to the serpin family. (392 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1208 aa) |
| | PSMF1 | Uncharacterized protein. (351 aa) |
| | LOC100524679 | Uncharacterized protein. (1397 aa) |
| | PCSK1N | Proprotein convertase subtilisin/kexin type 1 inhibitor. (259 aa) |
| | CSTB | Cystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa) |
| | PABPN1L | Poly(A) binding protein nuclear 1 like, cytoplasmic. (282 aa) |
| | ECM1 | Extracellular matrix protein 1. (559 aa) |
| | VTN | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (505 aa) |
| | CDK5 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa) |
| | LOC396905 | Sperm-associated acrosin inhibitor; Inhibits acrosin. (162 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (580 aa) |
| | PTTG1 | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa) |
| | WAP | Whey acidic protein; Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling. (132 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | TM4SF20 | Transmembrane 4 L six family member 20. (227 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | VIL1 | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | TFPI2 | Tissue factor pathway inhibitor. (232 aa) |
| | PICALM | Phosphatidylinositol binding clathrin assembly protein. (700 aa) |
| | AQP11 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa) |
| | TRIM21 | Tripartite motif containing 21. (474 aa) |
| | SPINK9 | Serine peptidase inhibitor, Kazal type 9. (84 aa) |
| | FNIP1 | Folliculin interacting protein 1. (1061 aa) |
| | CAST | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. (835 aa) |
| | C3 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (1661 aa) |
| | CD44 | CD44 molecule (Indian blood group). (767 aa) |
| | F2 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | SERPING1 | Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa) |
| | PRDX5 | Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (170 aa) |
| | CST6 | Cystatin E/M; Belongs to the cystatin family. (149 aa) |
| | SERPINA7 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. (420 aa) |
| | SNX12 | Sorting nexin 12. (175 aa) |
| | TIMP1 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | HRG | Uncharacterized protein. (561 aa) |
| | FETUB | Fetuin-B isoform 1. (377 aa) |
| | SERPINI2 | Serpin family I member 2; Belongs to the serpin family. (405 aa) |
| | LOC100736951 | Uncharacterized protein. (177 aa) |
| | KLHL40 | Kelch like family member 40. (623 aa) |
| | ITIH5 | Inter-alpha-trypsin inhibitor heavy chain 5. (944 aa) |
| | ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (923 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (646 aa) |
| | SPINK4 | Serine protease inhibitor Kazal-type 4; Inhibits the glucose-induced insulin secretion from perfused pancreas; also plays a role in the immune system. Does not inhibit trypsin. (86 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa) |
| | PRDX3 | Thioredoxin domain-containing protein. (261 aa) |
| | SUFU | SUFU negative regulator of hedgehog signaling. (432 aa) |
| | SERPIND1 | Serpin family D member 1; Belongs to the serpin family. (517 aa) |
| | SPOCK3 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (436 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1 isoform X1. (849 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | CCAR2 | DBC1 domain-containing protein. (916 aa) |
| | PCID2 | PCI domain-containing protein 2 isoform X1. (399 aa) |
| | SERPINE3 | Serpin family E member 3; Belongs to the serpin family. (408 aa) |
| | CSN2 | Beta-casein; Important role in determination of the surface properties of the casein micelles. (231 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4843 aa) |
| | CRIM1 | Cysteine rich transmembrane BMP regulator 1. (1031 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (413 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa) |
| | INTS1 | Integrator complex subunit 1. (2191 aa) |
