(24 nodes) Negative regulation of smoothened signaling pathway network (Sus scrofa)

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Your Input:
	GPR37L1	G protein-coupled receptor 37 like 1. (459 aa)
	RUNX2	Runt-related transcription factor 2 isoform a. (625 aa)
	ULK3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
	KCTD11	Potassium channel tetramerization domain containing 11. (271 aa)
	KCTD21	Potassium channel tetramerization domain containing 21. (305 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
	GLI1	Zinc finger protein GLI1 isoform X1. (1106 aa)
	HHIP	Hedgehog-interacting protein. (700 aa)
	MGRN1	Mahogunin ring finger 1. (571 aa)
	SERPINE2	SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
	MOSMO	Modulator of smoothened. (167 aa)
	TULP3	TUB like protein 3; Belongs to the TUB family. (472 aa)
	MEGF8	Multiple EGF like domains 8. (2789 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
	RB1	RB transcriptional corepressor 1. (938 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (432 aa)
	GLI3	GLI family zinc finger 3. (1586 aa)
	RACK1	Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to [...] (317 aa)
	KCTD6	Potassium channel tetramerization domain containing 6. (261 aa)
	GLIS2	GLIS family zinc finger 2. (596 aa)
	PTCH1	Protein patched homolog 1 isoform L. (1452 aa)
	GPC3	Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1095 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLI1	GLI3	ENSSSCP00000057276	ENSSSCP00000017756	Zinc finger protein GLI1 isoform X1.	GLI family zinc finger 3.	0.922
GLI1	GPR161	ENSSSCP00000057276	ENSSSCP00000006719	Zinc finger protein GLI1 isoform X1.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.405
GLI1	HHIP	ENSSSCP00000057276	ENSSSCP00000053296	Zinc finger protein GLI1 isoform X1.	Hedgehog-interacting protein.	0.708
GLI1	PRKACA	ENSSSCP00000057276	ENSSSCP00000035101	Zinc finger protein GLI1 isoform X1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.936
GLI1	PRKACB	ENSSSCP00000057276	ENSSSCP00000058922	Zinc finger protein GLI1 isoform X1.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.924
GLI1	PTCH1	ENSSSCP00000057276	ENSSSCP00000028104	Zinc finger protein GLI1 isoform X1.	Protein patched homolog 1 isoform L.	0.969
GLI1	RUNX2	ENSSSCP00000057276	ENSSSCP00000070509	Zinc finger protein GLI1 isoform X1.	Runt-related transcription factor 2 isoform a.	0.476
GLI1	SUFU	ENSSSCP00000057276	ENSSSCP00000011277	Zinc finger protein GLI1 isoform X1.	SUFU negative regulator of hedgehog signaling.	0.999
GLI1	ULK3	ENSSSCP00000057276	ENSSSCP00000068796	Zinc finger protein GLI1 isoform X1.	Unc-51 like kinase 3; Belongs to the protein kinase superfamily.	0.605
GLI3	GLI1	ENSSSCP00000017756	ENSSSCP00000057276	GLI family zinc finger 3.	Zinc finger protein GLI1 isoform X1.	0.922
GLI3	GPR161	ENSSSCP00000017756	ENSSSCP00000006719	GLI family zinc finger 3.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.531
GLI3	HHIP	ENSSSCP00000017756	ENSSSCP00000053296	GLI family zinc finger 3.	Hedgehog-interacting protein.	0.657
GLI3	PRKACA	ENSSSCP00000017756	ENSSSCP00000035101	GLI family zinc finger 3.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.948
GLI3	PRKACB	ENSSSCP00000017756	ENSSSCP00000058922	GLI family zinc finger 3.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.949
GLI3	PTCH1	ENSSSCP00000017756	ENSSSCP00000028104	GLI family zinc finger 3.	Protein patched homolog 1 isoform L.	0.831
GLI3	SUFU	ENSSSCP00000017756	ENSSSCP00000011277	GLI family zinc finger 3.	SUFU negative regulator of hedgehog signaling.	0.990
GLI3	TULP3	ENSSSCP00000017756	ENSSSCP00000000785	GLI family zinc finger 3.	TUB like protein 3; Belongs to the TUB family.	0.401
GLI3	ULK3	ENSSSCP00000017756	ENSSSCP00000068796	GLI family zinc finger 3.	Unc-51 like kinase 3; Belongs to the protein kinase superfamily.	0.587
GLIS2	SUFU	ENSSSCP00000025993	ENSSSCP00000011277	GLIS family zinc finger 2.	SUFU negative regulator of hedgehog signaling.	0.454
GPR161	GLI1	ENSSSCP00000006719	ENSSSCP00000057276	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	Zinc finger protein GLI1 isoform X1.	0.405