(46 nodes) Regulation of glucose import network (Sus scrofa)

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Your Input:
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (668 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	C1QTNF12	C1q and TNF related 12. (308 aa)
	RLN2	Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. (182 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (940 aa)
	HK2	Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
	SLC1A2	Amino acid transporter. (639 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	ERFE	Erythroferrone. (331 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
	POU4F2	POU domain protein. (408 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	MEF2A	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (505 aa)
	GPC3	Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
	GRB10	Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
	PID1	PID domain-containing protein. (223 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (734 aa)
	APPL1	Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (205 aa)
	OSTN	Musclin. (132 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
	A0A287ABS1_PIG	Uncharacterized protein. (178 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (157 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa)
	AKT2	Non-specific serine/threonine protein kinase. (525 aa)
	ADIPOQ	C1q domain-containing protein. (332 aa)
	ITLN2	Intelectin 2. (388 aa)
	CREBL2	cAMP-responsive element-binding protein-like 2. (120 aa)
	AKT1	Non-specific serine/threonine protein kinase. (785 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	A0A287B5K4_PIG	Protein kinase domain-containing protein. (62 aa)
	IRS2	Insulin receptor substrate 2. (1092 aa)
	ASPSCR1	ASPSCR1 tether for SLC2A4, UBX domain containing. (555 aa)
	RNASEL	2-5A-dependent ribonuclease. (743 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (656 aa)
	PLA2G1B	Phospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa)
	RTN2	Reticulon. (527 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ABS1_PIG	APPL1	ENSSSCP00000041260	ENSSSCP00000038724	Uncharacterized protein.	Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1.	0.738
A0A287ABS1_PIG	APPL2	ENSSSCP00000041260	ENSSSCP00000000895	Uncharacterized protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.732
A0A287ABS1_PIG	PIK3R1	ENSSSCP00000041260	ENSSSCP00000024885	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.438
A0A287B5K4_PIG	APPL1	ENSSSCP00000051570	ENSSSCP00000038724	Protein kinase domain-containing protein.	Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1.	0.732
A0A287B5K4_PIG	APPL2	ENSSSCP00000051570	ENSSSCP00000000895	Protein kinase domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.732
ADIPOQ	APPL1	ENSSSCP00000046998	ENSSSCP00000038724	C1q domain-containing protein.	Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1.	0.658
ADIPOQ	APPL2	ENSSSCP00000046998	ENSSSCP00000000895	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.432
ADIPOQ	FGF21	ENSSSCP00000046998	ENSSSCP00000003399	C1q domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.694
ADIPOQ	IGF1	ENSSSCP00000046998	ENSSSCP00000000915	C1q domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.623
ADIPOQ	INS	ENSSSCP00000046998	ENSSSCP00000044635	C1q domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.915
ADIPOQ	INSR	ENSSSCP00000046998	ENSSSCP00000014414	C1q domain-containing protein.	Tyrosine-protein kinase receptor.	0.450
ADIPOQ	IRS1	ENSSSCP00000046998	ENSSSCP00000061240	C1q domain-containing protein.	Insulin receptor substrate 1.	0.667
ADIPOQ	IRS2	ENSSSCP00000046998	ENSSSCP00000052323	C1q domain-containing protein.	Insulin receptor substrate 2.	0.475
ADIPOQ	LEP	ENSSSCP00000046998	ENSSSCP00000056831	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.971
AKT1	AKT2	ENSSSCP00000050721	ENSSSCP00000046221	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.902
AKT1	APPL1	ENSSSCP00000050721	ENSSSCP00000038724	Non-specific serine/threonine protein kinase.	Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1.	0.738
AKT1	APPL2	ENSSSCP00000050721	ENSSSCP00000000895	Non-specific serine/threonine protein kinase.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.732
AKT1	GSK3A	ENSSSCP00000050721	ENSSSCP00000003288	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein.	0.937
AKT1	IGF1	ENSSSCP00000050721	ENSSSCP00000000915	Non-specific serine/threonine protein kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.520
AKT1	INS	ENSSSCP00000050721	ENSSSCP00000044635	Non-specific serine/threonine protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.510